DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment GABBR2 and GABA-B-R1

DIOPT Version :9

Sequence 1:	NP_005449.5	Gene:	GABBR2 / 9568	HGNCID:	4507	Length:	941	Species:	Homo sapiens
Sequence 2:	NP_001246033.1	Gene:	GABA-B-R1 / 34878	FlyBaseID:	FBgn0260446	Length:	841	Species:	Drosophila melanogaster

Alignment Length:	844	Identity:	286/844 - (33%)
Similarity:	455/844 - (53%)	Gaps:	56/844 - (6%)

- Green bases have known domain annotations that are detailed below.

Human    31 LLLPLAPGAWGWARGAPRPPPSSPPLSIMGLMPLTKEVAKGSI--GRGVLPAVELAIEQIRNESL 93
            |.|..:|...|...|.|      ..|.|.|:.|:   ..||..  |:..:||..||::.:..:..
  Fly    14 LCLIASPHLQGGVAGRP------DELHIGGIFPI---AGKGGWQGGQACMPAARLALDDVNKQPN 69

Human    94 LRPYF-LDLRLYDTECDNAKGLKAFYDAIKYGPNHLMVFGGVCPSVTSIIAESLQGWNLVQLSFA 157
            |.|.| |.|...|:||:...|....|:.:...|..||:..| |.:|.:.:||:.:.|||:.|.:.
  Fly    70 LLPGFKLILHSNDSECEPGLGASVMYNLLYNKPQKLMLLAG-CSTVCTTVAEAAKMWNLIVLCYG 133

Human   158 ATTPVLADKKKYPYFFRTVPSDNAVNPAILKLLKHYQWKRVGTLTQDVQRFSEVRNDLTGVLYGE 222
            |::|.|:|:|::|..|||.||....||..:||:|.:.|.||..|.|..:.|.....||.......
  Fly   134 ASSPALSDRKRFPTLFRTHPSATVHNPTRIKLMKKFGWSRVAILQQAEEVFISTVEDLENRCMEA 198

Human   223 DIEISDTESFSNDPCTSVKKLKGNDVRIILGQFDQNMAAKVFCCAYEENMYGSKYQWIIPGWYEP 287
            .:||...:||.:||..:|:.|:..|.|||:|.|....|.:|.|..|::.:||..:.|...||||.
  Fly   199 GVEIVTRQSFLSDPTDAVRNLRRQDARIIVGLFYVVAARRVLCEMYKQQLYGRAHVWFFIGWYED 263

Human   288 SWWEQVHTEANSSRCLRKNLLAAMEGYIGVDFEPLSSKQIKTISGKTPQQYEREYNNKRSGVGPS 352
            :|:| |:.:|....|..:.:..|.||::..:....:.....||||.|.:::....|......|..
  Fly   264 NWYE-VNLKAEGITCTVEQMRIAAEGHLTTEALMWNQNNQTTISGMTAEEFRHRLNQALIEEGYD 327

Human   353 KFH-----GY-----AYDGIWVIAKTLQRAMETLHASSRHQRIQDFNYTDHTLGRIILNAMNETN 407
            ..|     ||     |||.:|.:|....:.||.|  ::..:.::||.|||..:...|..|||.|.
  Fly   328 INHDRYPEGYQEAPLAYDAVWSVALAFNKTMERL--TTGKKSLRDFTYTDKEIADEIYAAMNSTQ 390

Human   408 FFGVTGQVVFRN-GERMGTIKFTQFQDSREVKVGEYNAVADTLEIINDTIRFQGSEPPKDKTIIL 471
            |.||:|.|.|.: |:|:...:..|..|.:..|:|.|:...|.|..:| |.::.|.:.|:|:||:.
  Fly   391 FLGVSGVVAFSSQGDRIALTQIEQMIDGKYEKLGYYDTQLDNLSWLN-TEQWIGGKVPQDRTIVT 454

Human   472 EQLRKISLPLYSILSALTILGMIMASAFLFFNIKNRNQKLIKMSSPYMNNLIILGGMLSYASIFL 536
            ..||.:||||:..:..::..|:.:|.|.:.|||.|:::::|:.|.|..|.:::.|.::...|:.|
  Fly   455 HVLRTVSLPLFVCMCTISSCGIFVAFALIIFNIWNKHRRVIQSSHPVCNTIMLFGVIICLISVIL 519

Human   537 FGLDGSFVSEKTFETLCTVRTWILTVGYTTAFGAMFAKTWRVHAIFKNVKM-KKKIIKDQKLLVI 600
            .|:||.|||.:.:..:|..|.|:|:.|:|.|:||||:|.||||......|. .||.::..||..:
  Fly   520 LGIDGRFVSPEEYPKICQARAWLLSTGFTLAYGAMFSKVWRVHRFTTKAKTDPKKKVEPWKLYTM 584

Human   601 VGGMLLIDLCILICWQAVDPLRRTVEKYSMEPDPAGR--DISIRPLLEHCENTHMTIWLGIVYAY 663
            |.|:|.|||.||:.||..|||:|.:|.:.:| ||...  ||.|||.|||||:...::|||:||.:
  Fly   585 VSGLLSIDLVILLSWQIFDPLQRYLETFPLE-DPVSTTDDIKIRPELEHCESQRNSMWLGLVYGF 648

Human   664 KGLLMLFGCFLAWETRNVSIPALNDSKYIGMSVYNVGIMCIIGAAVSFLTRDQPNVQFCIVALVI 728
            |||:::||.|||:|||::.:..:|||:|:|||:|||.::|:|.|.|..:...|.:..|..|||.:
  Fly   649 KGLILVFGLFLAYETRSIKVKQINDSRYVGMSIYNVVVLCLITAPVGMVIASQQDASFAFVALAV 713

Human   729 IFCSTITLCLVFVPKLITLRTNPDAATQNRRFQFTQNQKKEDSKTSTSVTSVNQASTSRLEGLQS 793
            |||..:::.|:||||:|.:..:|              :.|.:||.:.. :::::....|.:.|.:
  Fly   714 IFCCFLSMLLIFVPKVIEVIRHP--------------KDKAESKYNPD-SAISKEDEERYQKLVT 763

Human   794 ENHRLRMKITELDKDLEEVTMQLQDTPE-KTTYIKQNHYQELNDILNLGNFTESTDGGKAILKN 856
            ||..|:..||:.::.:..:..:|.:..: |.|        |||....:.:...:|....|.|.|
  Fly   764 ENEELQRLITQKEEKIRVLRQRLVERGDAKGT--------ELNGATGVASAAVATTSQPASLIN 819

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
GABBR2	NP_005449.5	PBP1_GABAb_receptor	58..460	CDD:380589	134/415 (32%)
		7tmC_GABA-B-R2	480..749	CDD:320421	115/271 (42%)
		TM helix 1	481..505	CDD:320421	6/23 (26%)
		TM helix 2	517..538	CDD:320421	5/20 (25%)
		TM helix 3	554..576	CDD:320421	11/21 (52%)
		TM helix 4	599..615	CDD:320421	8/15 (53%)
		TM helix 5	653..676	CDD:320421	12/22 (55%)
		TM helix 6	689..711	CDD:320421	12/21 (57%)
		TM helix 7	718..743	CDD:320421	10/24 (42%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	763..790		4/26 (15%)
		GBR2_CC	779..817	CDD:375881	7/37 (19%)
GABA-B-R1	NP_001246033.1	PBP1_GABAb_receptor	34..437	CDD:107361	132/409 (32%)
		ANF_receptor	52..415	CDD:279440	119/366 (33%)
		7tm_3	476..730	CDD:278433	111/254 (44%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1055
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG49267
OrthoDB	1	1.010	-	-		D267884at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.830