Protein Alignment GTPBP1 and Dgp-1

DIOPT Version :10

• Sequence 1: XP_016884589.1
• Gene: GTPBP1 / 9567
• HGNCID: 4669
• Length: 726
• Species: Homo sapiens
• Sequence 2: NP_611302.1
• Gene: Dgp-1 / 37080
• FlyBaseID: FBgn0027836
• Length: 669
• Species: Drosophila melanogaster
• Alignment Length: 613
• Identity: 396/613 - (64%)
• Similarity: 466/613 - (76%)
• Gaps: 22/613 - (3%)

Human    53 LNGEPE------LDLTS---KLVLVSPTSEQYDSLLRQMWERMDEGCGETIYVIGQGSDGTEYGL 108
            ::|.|:      :|.:|   |.|||.||.||.:.|.:::.:|:.:.||||||.||.|.||::.||
  Fly    27 VDGLPQQMAAMSVDYSSIRGKDVLVQPTEEQIELLQKRLQDRIADNCGETIYEIGVGEDGSDSGL 91

Human   109 SEADMEASYATVKSMAEQIEADVILLRERQEAGGRVRDYLVRKRVGDNDFLEVRVAVVGNVDAGK 173
            :....|||.||:..:|..|:|||:.||||:...|:...:|:||.:...||:|:||||||||||||
  Fly    92 NPEQFEASVATLHLLAANIDADVVKLRERRAEKGQSAQFLIRKHIDTTDFMEIRVAVVGNVDAGK 156

Human   174 STLLGVLTHGELDNGRGFARQKLFRHKHEIESGRTSSVGNDILGFDSEGNVVNKPDSHGGSLEWT 238
            |||||||||||||||||.|||:||||||||||||||||||||||||..||||||||.  |.|:|.
  Fly   157 STLLGVLTHGELDNGRGHARQRLFRHKHEIESGRTSSVGNDILGFDGVGNVVNKPDH--GHLDWV 219

Human   239 KICEKSTKVITFIDLAGHEKYLKTTVFGMTGHLPDFCMLMVGSNAGIVGMTKEHLGLALALNVPV 303
            ||||.|.||||||||||||:||||||||||||.|||.|||:|:||||:|||||||||||||.|||
  Fly   220 KICENSAKVITFIDLAGHERYLKTTVFGMTGHAPDFGMLMIGANAGIIGMTKEHLGLALALAVPV 284

Human   304 FVVVTKIDMCPANILQETLKLLQRLLKSPGCRKIPVLVQSKDDVIVTASNFSSERMCPIFQISNV 368
            |||||||||||||:|||.:|||.::|||.||||:||:|:|.|||:::|:||.|||:|||||:|||
  Fly   285 FVVVTKIDMCPANVLQENMKLLFKMLKSQGCRKVPVVVRSHDDVVLSATNFVSERLCPIFQVSNV 349

Human   369 TGENLDLLKMFLNLLSPRTSYREEEPAEFQIDDTYSVPGVGTVVSGTTLRGLIKLNDTLLLGPDP 433
            ||:||:||||||||||.|....|..||||||||.|:|||||||||||.|:|.|:|||.|:||||.
  Fly   350 TGDNLELLKMFLNLLSTRMPGSESLPAEFQIDDVYAVPGVGTVVSGTCLQGTIRLNDCLMLGPDA 414

Human   434 LGNFLSIAVKSIHRKRMPVKEVRGGQTASFALKKIKRSSIRKGMVMVSPRLNPQASWEFEAEILV 498
            :|:|:.|.:||||||||.|..||.|||||||||||||:.:||||||||..|.|||.||||.||||
  Fly   415 VGSFVPITIKSIHRKRMNVARVRCGQTASFALKKIKRAYLRKGMVMVSQDLKPQACWEFEGEILV 479

Human   499 LHHPTTISPRYQAMVHCGSIRQTATILSMDKDCLRTGDKATVHFRFIKTPEYLHIDQRLVFREGR 563
            ||||||||.|||||||||||||||:|:.|.:|||||||||.|.|||||.|||:...|||||||||
  Fly   480 LHHPTTISARYQAMVHCGSIRQTASIIHMSRDCLRTGDKAHVKFRFIKQPEYIRAGQRLVFREGR 544

Human   564 TKAVGTITKLLQTTNNSPMNSKPQQIKMQSTKKGPLTKRDEGGPSGGPAVGAPPPGDEASSVGAG 628
            |||||.|.:.|.....||...||  .||||        |...|.|.|........| :.||.|||
  Fly   545 TKAVGNILRPLPNAAASPYRPKP--AKMQS--------RSHNGGSNGSNNQHRQQG-QGSSSGAG 598

Human   629 QPAASSNLQPQPKPSSGGRRRGGQRHKS 656
            ....:::.:.......||.||||:|.::
  Fly   599 CSKDNADEKQNGDKREGGSRRGGKRKRN 626

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
GTPBP1	XP_016884589.1	GTPBP1	77..574	CDD:444076	358/496 (72%)
Dgp-1	NP_611302.1	GTPBP1	55..556	CDD:444076	360/502 (72%)
		dermokine	<561..>651	CDD:455732	25/77 (32%)