Protein Alignment GTPBP1 and cgp-1

DIOPT Version :10

• Sequence 1: XP_016884589.1
• Gene: GTPBP1 / 9567
• HGNCID: 4669
• Length: 726
• Species: Homo sapiens
• Sequence 2: NP_503137.1
• Gene: cgp-1 / 178540
• WormBaseID: WBGene00000480
• Length: 613
• Species: Caenorhabditis elegans
• Alignment Length: 622
• Identity: 322/622 - (51%)
• Similarity: 421/622 - (67%)
• Gaps: 37/622 - (5%)

Human    30 RAAAAAARLHGGFDSDCSEDGEALNGEPELDLTSKLVLVSPTSEQYDSLLRQMWERMDEGCGETI 94
            :.|.....|:...:.|.||..:...|     |.::.:|.| |.|..:..:..:.:::.||.||.:
 Worm     9 KKATNLCELYADGNDDDSEKEQQDRG-----LDAQFLLRS-TPEDVEKYMIHVRKQLMEGEGECL 67

Human    95 YVIG----QGSDGTEYGLSEADMEASYATVKSMAEQIEA-DVILLRERQEAGGRV--RDYLVRKR 152
            ..:|    ..|...:.||||.|::.:......:.|:|.| ...::|.:|..||.:  ..:::|..
 Worm    68 VELGAPINSNSKNPKSGLSEEDLDKAADAQLKILEKIPAVGTKVIRRKQTGGGSLFTEVWIIRDP 132

Human   153 VGDNDFLEVRVAVVGNVDAGKSTLLGVLTHGELDNGRGFARQKLFRHKHEIESGRTSSVGNDILG 217
            ..:.||:|.|||||||||||||||||||||..||:|||.||.||||||||.||||||||||||||
 Worm   133 PTEKDFIEARVAVVGNVDAGKSTLLGVLTHSALDDGRGAARTKLFRHKHEFESGRTSSVGNDILG 197

Human   218 FDSEGNVVNKPDSHGGSLEWTKICEKSTKVITFIDLAGHEKYLKTTVFGMTGHLPDFCMLMVGSN 282
            ||..||:|||||.|..:|:|.:|.....|::|||||||||||||||:||||||:||:.|||:|:|
 Worm   198 FDVHGNIVNKPDPHNHNLDWVQIGSDCAKLVTFIDLAGHEKYLKTTIFGMTGHMPDYTMLMIGAN 262

Human   283 AGIVGMTKEHLGLALALNVPVFVVVTKIDMCPANILQETLKLLQRLLKSPGCRKIPVLVQSKDDV 347
            .||:|.|||||.|||:|:|||::|||||||||||||:||:|.:.||::|  .:|:|:||::.|||
 Worm   263 MGIIGTTKEHLSLALSLHVPVYLVVTKIDMCPANILEETMKNITRLVRS--AKKLPILVRNMDDV 325

Human   348 IVTASNFSSERMCPIFQISNVTGENLDLLKMFLNLLSPRTSYREEEPAEFQIDDTYSVPGVGTVV 412
            :..|.||.|:::|||||:|||.|.||.||:.|||::..|....|.:||.|||||.|.|.||||:.
 Worm   326 VHAAVNFPSKKVCPIFQVSNVEGTNLPLLRQFLNIVPLRRQLNENDPAHFQIDDIYWVDGVGTIA 390

Human   413 SGTTLRGLIKLNDTLLLGPDPLGNFLSIAVKSIHRKRMPVKEVRGGQTASFALKKIKRSSIRKGM 477
            |||.|.|.|:|||.|||||...|:|:.|.:||||||||||..|:.||:||||||||.:..:||||
 Worm   391 SGTLLSGTIRLNDILLLGPTSNGDFMPIPIKSIHRKRMPVGIVKCGQSASFALKKIPKKDVRKGM 455

Human   478 VMVSPRLNPQASWEFEAEILVLHHPTTISPRYQAMVHCGSIRQTATILSMDKDCLRTGDKATVHF 542
            |:|.|::.|.||..||||||||||||||.|.||||:|.||:|||||::||.|:.|||||:..|.|
 Worm   456 VLVDPKVKPVASMVFEAEILVLHHPTTIKPNYQAMLHIGSVRQTATLVSMGKEVLRTGDRDKVQF 520

Human   543 RFIKTPEYLHIDQRLVFREGRTKAVGTITKLLQTTNNSPMNSKPQQIKMQSTKKGPLTKRDEGGP 607
            :||:.|||:....::||||||||||||::.::      |..|..||...|  |.|  .::..|..
 Worm   521 KFIRQPEYIRPGTKMVFREGRTKAVGTVSSVV------PQESLAQQRAKQ--KDG--RQKQYGKK 575

Human   608 SGGPAVGAPPPGD---------EASSVGAGQPAASSN 635
            |.||   .||.|.         :|.|:.....|||::
 Worm   576 SMGP---KPPNGKPKEKIEKKLDALSIEQLTSAASTS 609

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
GTPBP1	XP_016884589.1	GTPBP1	77..574	CDD:444076	292/503 (58%)
cgp-1	NP_503137.1	GTPBP1	56..553	CDD:444076	292/504 (58%)