DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment BCAR1 and p130CAS

DIOPT Version :9

Sequence 1:	NP_001164185.1	Gene:	BCAR1 / 9564	HGNCID:	971	Length:	916	Species:	Homo sapiens
Sequence 2:	NP_001097456.2	Gene:	p130CAS / 38021	FlyBaseID:	FBgn0035101	Length:	831	Species:	Drosophila melanogaster

Alignment Length:	935	Identity:	248/935 - (26%)
Similarity:	374/935 - (40%)	Gaps:	273/935 - (29%)

- Green bases have known domain annotations that are detailed below.

Human    54 AKALYDNVAESPDELSFRKGDIMTVLEQDTQGLDGWWLCSLHGRQGIVPGNRLKILVGMYDKKPA 118
            |||:|||.|::.|||.|:||||:|||||||:|..|||||||..|||:.|||||::| ..||.
  Fly    82 AKAIYDNYADTSDELPFKKGDILTVLEQDTEGFQGWWLCSLRNRQGLCPGNRLRVL-NSYDS--- 142

Human   119 GPGPGPPATPAQPQPGLHAPAPPASQYTPMLPNTYQPQPDSVYLVPTPSKAQQGLYQVPGPSPQF 183
                           |..:|:|.:|                    |.||.
  Fly   143 ---------------GCFSPSPASS--------------------PVPSL--------------- 157

Human   184 QSPPAKQTSTFSKQTPHHPFPSPATDLYQ----------VPPGPGGPAQDIYQVPPSAGMGHDIY 238
                |..|:|.....       .:.::|:          .....||         .|:|:|.:..
  Fly   158 ----AASTATLDSSI-------CSAEIYENGSVISAVSSSNSNSGG---------ASSGLGSESV 202

Human   239 QVPPSMDTRSWEGTKPPAKVVVPTRVGQGYVYE--------------AAQPEQDEYDIPRHLLAP 289
            .   .:..|||..:  |.||:.|.|.|..|:|.              .:.|:|..|
  Fly   203 S---RVSRRSWHAS--PTKVITPQRHGDVYIYNYSPGSATGSGARAAPSTPQQQIY--------- 253

Human   290 GPQDIYD-----VPPVRGLLPSQYGQEVYDTPPMAVKGPNGRDPLLEVYDVPPSVEKGLPPSNHH 349
            ..|.||.     ..|.:....|::  |.||.|..|...|..       ||.|.|   |||.:::.
  Fly   254 SNQSIYQNFAMMSSPRQNASGSEF--ETYDIPKPATPVPLN-------YDSPRS---GLPKASNS 306

Human   350 AV---------YDVPPSVSKDVPDGPLLREETYDVPPAFAKAKPFDPARTPLVLAAPPPDSPPAE 405
            ..         ::...||:..:      .||:||||             .||:|.:    :...:
  Fly   307 TTTSSSSLGTRFETLKSVAASI------AEESYDVP-------------RPLILGS----NQLQQ 348

Human   406 DVYDVPPPA--------------------PDLYDVPPGLRRPGPGTLYDVPRERVLPPEVADGGV 450
            .:..:.|.:                    ..|.::|.          ||:||...||......|:
  Fly   349 QMSQMTPSSSASSLLTSDSLSLSFSSSNRSSLANMPD----------YDIPRRNPLPVRRQQSGL 403

Human   451 VDSGVYAVP-PPAEREAPAEGKRLSASSTGSTRSSQSASSLEVAGPGREPLELEVAVEALARLQQ 514
                .|..| ||.:.:.|   :.|...||.:|....             ||||..|:|.||:||.
  Fly   404 ----TYDFPLPPLQEQVP---RVLCTPSTVTTTKEL-------------PLELSSALETLAKLQL 448

Human   515 GVSATVAHLLDLAGSAGATGSWRSPSEPQEPLVQDLQAAVAAVQSAVHELLEFARSAVGNAAHTS 579
            ..:|.:..||..     ...:||:.:: .||.:.||:.|...:::.:|:|.||...|:|||..:.
  Fly   449 QTTAAINRLLSF-----VVPNWRTRAQ-LEPAIMDLKLAALRLRTTLHDLAEFGEGALGNATRSE 507

Human   580 DRALHAKLSRQLQKMEDVHQTLVAHGQALDAGRGGS-----------GATLED-LDRLVACSRAV 632
            ||.|..||...::.:.|.::.:....::|||....|           |....| ||:|:.|::.:
  Fly   508 DRNLALKLRPLVRALRDANKLIHDSSESLDAQGAWSIDQLARSDEKHGCRPPDALDQLMVCAQTL 572

Human   633 PEDAKQLASFLHGNASLLFRRTKATAPGPEGGGTLHPNPTDKTSSIQSRPLPSPPKFTSQDSPDG 697
            .||.:...||:.|||||||:|....  |..||                             |..|
  Fly   573 TEDVRSTTSFIQGNASLLFKRQLTV--GHNGG-----------------------------SGTG 606

Human   698 QYENSEGG--WMEDYDYVHLQGKEEFEKTQKELLEKGSITRQGKSQLELQQLKQFERLEQEVSRP 760
            ..|.|.|.  |:||||||..:.|:...:..:.|.|  :|....|:|.:     ...|..:..:..
  Fly   607 VLEGSRGSAEWLEDYDYVAFESKDAAARKNEALRE--AIPADLKTQFD-----TVIRTAESSAMG 664

Human   761 IDHDLANWTP---AQPLAPGRTGGLGPSDRQLLLFYLEQCEANLTTLTNAVDAFFTAVATNQPPK 822
            ........||   ..|..|.::..:...|::|:.:|.:|...::..|..|:|:|...|..|||||
  Fly   665 AGSGSIPTTPTARTTPTTPCKSPEMTDKDKKLVRYYAQQISTHMGNLMQAIDSFLETVEKNQPPK 729

Human   823 IFVAHSKFVILSAHKLVFIGDTLSRQAKAADVRSQVTHYSNLLCDLLRGIVATTKAAALQYPSPS 887
            .|:|:.|||::|||.||.|||.:.|......:|.::...:|.|.|.|:..|..:|.||..:||.|
  Fly   730 FFIAYGKFVVVSAHNLVTIGDNVYRNISKEALREKILRCTNALSDALKTCVLKSKKAAAHFPSGS 794

Human   888 AAQDMVERVKELGHSTQQFRRVLGQ 912
            |.|:||:.|..:.:..:..:.|:.|
  Fly   795 AVQEMVDSVVHINNLARDLKSVMLQ 819

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
BCAR1	NP_001164185.1	SH3_BCAR1	51..117	CDD:212934	41/62 (66%)
		Serine_rich_BCAR1	500..656	CDD:211406	55/167 (33%)
		DUF3513	701..910	CDD:288849	65/213 (31%)
p130CAS	NP_001097456.2	SH3_CAS	81..136	CDD:212778	38/53 (72%)
		Serine_rich_CAS	434..596	CDD:211403	55/167 (33%)
		DUF3513	612..817	CDD:288849	64/211 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165143743
Domainoid	1	1.000	122	1.000	Domainoid score	I5642
eggNOG	1	0.900	-	-		E1_28I76
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	254	1.000	Inparanoid score	I3193
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG46840
OrthoDB	1	1.010	-	-		D1086228at2759
OrthoFinder	1	1.000	-	-		FOG0004232
OrthoInspector	1	1.000	-	-		otm41781
orthoMCL	1	0.900	-	-		OOG6_108346
Panther	1	1.100	-	-	O	PTHR10654
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4915
SonicParanoid	1	1.000	-	-		X2975
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	15	14.800