DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CHD1L and smarca4

DIOPT Version :9

Sequence 1:	NP_004275.4	Gene:	CHD1L / 9557	HGNCID:	1916	Length:	897	Species:	Homo sapiens
Sequence 2:	NP_001362194.1	Gene:	smarca4 / 496545	XenbaseID:	XB-GENE-483983	Length:	1599	Species:	Xenopus tropicalis

Alignment Length:	827	Identity:	283/827 - (34%)
Similarity:	405/827 - (48%)	Gaps:	114/827 - (13%)

- Green bases have known domain annotations that are detailed below.

Human    26 AEAARVQEQDLRQWGL--TGIHLRSYQLEGVNWLAQRFHCQNGCILGDEMGLGKTCQTIALFIYL 88
            |.|..|.|:..:|..|  .|| |:.||::|:.||...::.....||.||||||||.|||||..||
Frog   717 AVAHAVSEKVDKQSTLLVNGI-LKQYQIKGLEWLVSLYNNNLNGILADEMGLGKTIQTIALITYL 780

Human    89 AGRLNDEGPFLILCPLSVLSNWKEEMQRFAPGLSCVTYAGDKEERACLQQDLKQESRFHVLLTTY 153
            .......|||||:.|||.||||..|..::.|.:..|:|.|....|......|: ..:|:||||||
Frog   781 MEHKRINGPFLIIVPLSTLSNWVYEFDKWGPSVVKVSYKGSPAARRAFVPMLR-SGKFNVLLTTY 844

Human   154 EICLKDASFLKSFPWSVLVVDEAHRLKNQSSLLHKTLSEFSVV-FSLLLTGTPIQNSLQELYSLL 217
            |..:||...|....|..::|||.||:||....|.:.|:...|. ..:||||||:||.|.||::||
Frog   845 EYIIKDKHILAKIRWKYMIVDEGHRMKNHHCKLTQVLNTHYVAPRRVLLTGTPLQNKLPELWALL 909

Human   218 SFVEPDLFSKEEVGDFIQRYQ----------DIEKESE--SASELHKLLQPFLLRRVKAEVATEL 270
            :|:.|.:|  :....|.|.:.          |:.:|..  ....|||:|:||||||:|.||..:|
Frog   910 NFLLPTIF--KSCSTFEQWFNAPFAMTGEKVDLNEEETILIIRRLHKVLRPFLLRRLKKEVEAQL 972

Human   271 PKKTEVVIYHGMSALQKKYY-----KAILMKDLDAFENETAKKVK-----LQNILSQLRKCVDHP 325
            |:|.|.||...||:||:..|     |.:|:.|    .:|..||.|     |.|.:.||||..:||
Frog   973 PEKVEYVIKCDMSSLQRVLYRHMQAKGVLLTD----GSEKDKKGKGGTKTLMNTIMQLRKICNHP 1033

Human   326 YLFDGVEPEPFE----------VGDHLTEASGKLHLLDKLLAFLYSGGHRVLLFSQMTQMLDILQ 380
            |:|..:| |.|.          .|..|..||||..|||::|..|.:..|:||||.|||.::.|::
Frog  1034 YMFQHIE-ESFSEHLGFSGGIVQGADLYRASGKFELLDRILPKLRATQHKVLLFCQMTTLMTIME 1097

Human   381 DYMDYRGYSYERVDGSVRGEERHLAIKNFGQ--QPIFVFLLSTRAGGVGMNLTAADTVIFVDSDF 443
            ||..|||:.|.|:||:.:.|:|.:.:|.|.:  ...|:|||||||||:|:||.:|||||..|||:
Frog  1098 DYFAYRGFKYLRLDGTTKAEDRGMLLKTFNESSSEYFIFLLSTRAGGLGLNLQSADTVIIFDSDW 1162

Human   444 NPQNDLQAAARAHRIGQNKSVKVIRLIGRDTVEEIVYRKAASKLQLTNMIIEGGHFTLGAQKPAA 508
            ||..||||..|||||||...|:|:||...::|||.:...|..||.:...:|:.|.|.   ||.:
Frog  1163 NPHQDLQAQDRAHRIGQQNEVRVLRLCTVNSVEEKILAAAKYKLNVDQKVIQAGMFD---QKSS- 1223

Human   509 DADLQLSEILKFGLDKLLASEGSTMDEIDLESILGETKDGQWVSDALPAAEGGSRDQEEGK--NH 571
                  |...|..|..:|..|....:|       .|..|.:.|:..:      :|.:||..  ..
Frog  1224 ------SHERKVFLQAILEHEEQDEEE-------DEVPDDETVNQMI------ARHEEEFDLFMR 1269

Human   572 MYLFEGKDYSKEPSKEDRKSFEQLVNLQKTLLEKASQEGRSLRNKGSVLIPGLVEGSTKRKRVLS 636
            |.|...::.::.|.::.|...|.  .|...:::..::..|....:....:.|  .||..||.|..
Frog  1270 MDLDRRREEARNPKRKPRLMEED--ELPSWIIKDDAEVERLTCEEEEEKMFG--RGSRNRKEVDY 1330

Human   637 PEELEDRQ--KKRQEAAAKRRRLIEEKKRQKEEAEHKKKMAWWESNNYQSFCLPSEESEPEDLEN 699
            .:.|.::|  |..:|...:.   |||:.|||:....:|:..        ..|:....:.....|.
Frog  1331 SDSLTEKQWLKAIEEGTLEE---IEEEVRQKKTTRKRKRDI--------DPCIVMPTTSTRGRER 1384

Human   700 GEESSAELDYQDPDATSLKYVSGDVTHPQAGAEDALIVHCVDDSGHWGR--GGLFTALEKRSAEP 762
            .:|...:.....|.|..|......:|.......||:|.:  .|||: ||  ..:|..|..|...|
Frog  1385 DDEGKKQKKRGRPPAEKLSPNPPKLTKKMKKIVDAVIKY--KDSGN-GRQLSEVFIQLPSRKELP 1446

Human   763 RKIYELAGKMKDLSLGGVLLFPVDDKESRNKGQDLLALIVAQHRDRS 809
             :.|||..|            |||.::.:.:        :..|:.||
Frog  1447 -EYYELIRK------------PVDFRKIKER--------IRNHKYRS 1472

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CHD1L	NP_004275.4	SNF2_N	46..699	CDD:331286	247/691 (36%)
		DEAH box	174..177		2/2 (100%)
		Required for helicase activity. /evidence=ECO:0000269\|PubMed:29220653	615..673		16/59 (27%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	628..654		8/27 (30%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	687..711		2/23 (9%)
		Macro_Poa1p_like_SNF2	716..866	CDD:239447	24/96 (25%)
smarca4	NP_001362194.1	QLQ	164..198	CDD:370169
		SMC_prok_A	341..>560	CDD:274009
		HSA	446..516	CDD:369406
		BRK	597..639	CDD:197800
		DEXHc_SMARCA4	715..965	CDD:350820	102/251 (41%)
		PLN03142	734..>1216	CDD:215601	208/490 (42%)
		SnAC	1275..1340	CDD:373166	13/68 (19%)
		Bromo_SNF2L2	1408..1515	CDD:99947	23/89 (26%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
NCBI	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.910