DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CHD1L and fft2

DIOPT Version :9

Sequence 1:	NP_004275.4	Gene:	CHD1L / 9557	HGNCID:	1916	Length:	897	Species:	Homo sapiens
Sequence 2:	NP_587731.1	Gene:	fft2 / 2539045	PomBaseID:	SPCC1235.05c	Length:	1284	Species:	Schizosaccharomyces pombe

Alignment Length:	845	Identity:	250/845 - (29%)
Similarity:	377/845 - (44%)	Gaps:	206/845 - (24%)

- Green bases have known domain annotations that are detailed below.

Human    44 IHLRSYQLEGVNWLAQRFHCQNGCILGDEMGLGKTCQTIALFIYLAGRLNDEGPFLILCPLSVLS 108
            :.|:||||.|||||...:..:...||.||||||||||.:|.|..|..: ...||.|::.|.|.|.
pombe   548 VQLKSYQLVGVNWLHLLYQQKLSGILADEMGLGKTCQVVAFFALLLEQ-GHHGPHLVVVPSSTLE 611

Human   109 NWKEEMQRFAPGLSCVTYAGDKEERACLQQDLKQ-ESRFHVLLTTYEICL---KDASFLKSFPWS 169
            ||..|:.||.|.|....|.|.::|||.:::.::: |.::.:|:|||::..   :|.||||...:.
pombe   612 NWLRELARFCPSLRVEPYYGSQQERANIREAIEENEIKYDILVTTYQLATNNKEDRSFLKHQNFD 676

Human   170 VLVVDEAHRLKNQSSLLHKTLSEFSVVFSLLLTGTPIQNSLQELYSLLSFVEPDLFSKE-EVGDF 233
            |.|.||.|.|||:.|..:|.|...:..|.|||||||:||:|:||.|||:|:.|::|..: :..|.
pombe   677 VCVYDEGHYLKNRMSERYKHLMNLNANFRLLLTGTPLQNNLKELVSLLAFILPNMFDSDMDDLDV 741

Human   234 IQRYQ-----DIEK---ESESASELHKLLQPFLLRRVKAEVATELPKKTEVV-----------IY 279
            |.:.:     |||:   ..:..|....::.||:|||.|.:|..:|||||:::           ||
pombe   742 IFKAKPTADADIEQALLSKQRISRAKTMMTPFVLRRRKNQVLNDLPKKTQIIEHCKLSENQLEIY 806

Human   280 HGMSALQKKYYKAILMKD------LDAFENETAKKVKLQNILSQLRKCVDHPYLF---------- 328
            :..:||||...   |.:|      ....|....|.:...::|.||||..:|..||
pombe   807 NRYAALQKNQQ---LRRDDKRNKRSKNDEESDGKSLSAGHVLMQLRKAANHALLFRKFYDDEKLK 868

Human   329 ----DGVEPEPFE---------------------------------VGDHLTEASGKLHLLDKLL 356
                |.::.|.::                                 :.|.....|||:.:|.:||
pombe   869 QMAKDIMQEEQYKNANEQYIYEDMEVMSDFELHRLCRSFPTLQSYTLKDDPWMDSGKIRVLKELL 933

Human   357 AFLYSGGHRVLLFSQMTQMLDILQDYMDYRGYSYERVDGSVRGEERHLAIKNF-GQQPIFVFLLS 420
            ..:...|.|:|||||.|||||||:..:|....||.|:|||.:.|.|...|..| .::.:.|||||
pombe   934 PKMKEEGSRILLFSQFTQMLDILEQVLDTLKISYVRLDGSTQVEVRQDIIDQFHKEEDVTVFLLS 998

Human   421 TRAGGVGMNLTAADTVIFVDSDFNPQNDLQAAARAHRIGQNKSVKVIRLIGRDTVEEIVYRKAAS 485
            |:|||.|:||..|:.||..|..:||.:||||..||||:||.:.|.|||||..:|:||.:.:.|.:
pombe   999 TKAGGFGINLACANVVILYDCSYNPFDDLQAEDRAHRVGQVREVTVIRLITDNTIEEYIQKLANT 1063

Human   486 KLQLTNMIIEGGHFTLGAQKPAADADLQLSEILKFGLDKLLASEGSTMDEID---LESILGETKD 547
            ||                                 .||..|:|:|...:||.   ::.:|.|..:
pombe  1064 KL---------------------------------ALDMSLSSDGKDREEIGERLVQDMLDEENN 1095

Human   548 GQWVSDALPAAEGGSRDQEEGKNHMYLFEGKDYSKEPSKEDRKSFEQLVNLQKTLLEKASQEGRS 612
            |   ::..|...|...|.|      :.....:.||:...|:..:...|...|...:||..
pombe  1096 G---NNTKPEITGNESDGE------FKVSSSNNSKQTDAEETNTGVPLEGSQPNSVEKTD----- 1146

Human   613 LRNKGSVLIPGLVEGSTKRKRVLSPEELEDRQKKRQEAAAKRRRLIEEKKRQKEEAEHKKKMAWW 677
                       |.:|..|                        ..:..|.|.:..|.::|:.....
pombe  1147 -----------LADGDEK------------------------ANIKTEMKSETVEGDNKELRETM 1176

Human   678 ESNNYQ---SFCLPSEESEPEDLENGEESSAELDYQDPDATSL-----KYVSGD--VTHPQAGAE 732
            :..|.|   :..:||.:|..|: .|....|..||. |.:|:.:     |...||  ||..|..|.
pombe  1177 KGENVQTDSNAAVPSSKSSTEE-PNESVLSGHLDL-DTEASPVVSTIEKTTKGDVSVTEEQQSAN 1239

Human   733 DALIVHCVDDSGHWGRGGLFTALEKRSAEPRKIYELAGKMKDLSLGGVLLFPVDDKESRNKGQDL 797
                   :|..           |||...|..|..::   :..:||.      :::::.:||..::
pombe  1240 -------IDGQ-----------LEKPEIEESKKPDV---LNQVSLS------IEEEKPKNKESEV 1277

Human 798 797
pombe 1278 1277

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CHD1L	NP_004275.4	SNF2_N	46..699	CDD:331286	227/736 (31%)
		DEAH box	174..177		2/2 (100%)
		Required for helicase activity. /evidence=ECO:0000269\|PubMed:29220653	615..673		7/57 (12%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	628..654		1/25 (4%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	687..711		8/23 (35%)
		Macro_Poa1p_like_SNF2	716..866	CDD:239447	17/89 (19%)
fft2	NP_587731.1	Forkhead_N	82..>182	CDD:254796
		SNF2_N	553..858	CDD:278600	115/308 (37%)
		DEXDc	570..712	CDD:238005	60/142 (42%)
		Helicase_C	923..1037	CDD:278689	57/113 (50%)
		PHA03151	1091..>1234	CDD:177546	37/193 (19%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910