DRSC/TRiP Functional Genomics Resources

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Protein Alignment IGDCC3 and robo2

DIOPT Version :9

Sequence 1:NP_004875.2 Gene:IGDCC3 / 9543 HGNCID:9700 Length:814 Species:Homo sapiens
Sequence 2:NP_001259868.1 Gene:robo2 / 44522 FlyBaseID:FBgn0002543 Length:1519 Species:Drosophila melanogaster


Alignment Length:784 Identity:210/784 - (26%)
Similarity:292/784 - (37%) Gaps:208/784 - (26%)


- Green bases have known domain annotations that are detailed below.


Human    19 RLLLPLLLLLLPAPSEGL-------GHSAELAFAVEPSDDVAVP-GQPIVLDCRVEGTPPVRITW 75
            |.:.||||||  |...||       |.:..:   :|...|..|| ..|...:|:.||.|...|.|
  Fly    65 RAVFPLLLLL--AGLNGLTQVGALKGENPRI---IEHPMDTTVPKNDPFTFNCQAEGNPTPTIQW 124

Human    76 RKNGVELPEST--HSTLLANGSLM---IRHFRLEPGGSPSDEGDYECVAQNRFGLVVSRKARIQA 135
            .|:|.||...|  |..:|..|.|.   :.|.|.|     ||.|.|.|.|:|.||:..||.|.:|.
  Fly   125 FKDGRELKTDTGSHRIMLPAGGLFFLKVIHSRRE-----SDAGTYWCEAKNEFGVARSRNATLQV 184

Human   136 ATMSD-FHVHPQATVGEEGGVARFQCQI-HGLPKPLITWEKNRVPID-TDNERYTLLPKGVLQIT 197
            |.:.| |.:.|..|...:|.||..:|.. .|.|:|.|:|.||...:: ..|:|..::..|.|.|.
  Fly   185 AFLRDEFRLEPANTRVAQGEVALMECGAPRGSPEPQISWRKNGQTLNLVGNKRIRIVDGGNLAIQ 249

Human   198 GLRAEDGGIFHCVASNIASIRISHGARLTVSGSGSGAYKEPAILVGPENLTLTVHQTAVLECVAT 262
            ..|..|.|.:.||..|:...|.|..|.|.|       :..|.::.||:|.|..|..:.|.:|...
  Fly   250 EARQSDDGRYQCVVKNVVGTRESATAFLKV-------HVRPFLIRGPQNQTAVVGSSVVFQCRIG 307

Human   263 GNPRPIVSWSR-LDGRPIGVEGIQVLGTGNLIISDVTVQHSGVYVCAANRPGTRVRRTAQGRLVV 326
            |:|.|.|.|.| ..|..:.:..:.||...:|.:.|||::..|.|.|.|:.....:  ||.|.|.|
  Fly   308 GDPLPDVLWRRTASGGNMPLRRVHVLEDRSLKLDDVTLEDMGEYTCEADNAVGGI--TATGILTV 370

Human   327 QAPAEFVQHPQSISRPAGTTAMFTCQAQGEPPPHVTWL--KNGQVLGPG---------------- 373
            .||.:||..|::.....|...:|.|||.|.|.|.:.|.  .|..:|.||                
  Fly   371 HAPPKFVIRPKNQLVEIGDEVLFECQANGHPRPTLYWSVEGNSSLLLPGYRDGRMEVTLTPEGRS 435

Human   374 ------------------------GHV-------------------------------------- 376
                                    |.|                                      
  Fly   436 VLSIARFAREDSGKVVTCNALNAVGSVSSRTVVSVDTQFELPPPIIEQGPVNQTLPVKSIVVLPC 500

Human   377 --------------------------RLKNNNSTLTISGI-GPEDEAIYQCVAENSAGSSQASAR 414
                                      |..::...||||.: ..|||.:|.|||.|..|.|..|..
  Fly   501 RTLGTPVPQVSWYLDGIPIDVQEHERRNLSDAGALTISDLQRHEDEGLYTCVASNRNGKSSWSGY 565

Human   415 LTV----------LWAEGL---PGPPRNVRAVSVSSTEVRVSWSEP-LANTKEIIGYVLHI-RKA 464
            |.:          ..|..|   ||||...:.|......|.:||:.. ......::|||:.: .|.
  Fly   566 LRLDTPTNPNIKFFRAPELSTYPGPPGKPQMVEKGENSVTLSWTRSNKVGGSSLVGYVIEMFGKN 630

Human   465 ADPPELEYQEAVSKSTFQHLVSDLEPSTAYSFYIKAYTPRG---ASSASVPTLAST--------L 518
            .....:.....|..:||..  :.|.|...|.|.|:|....|   .|..|.|....|        |
  Fly   631 ETDGWVAVGTRVQNTTFTQ--TGLLPGVNYFFLIRAENSHGLSLPSPMSEPITVGTRYFNSGLDL 693

Human   519 GEAPAP------PPLS-VRVLGSSSLQLLWEPWPRLAQHEGGFKLFYR---------PASKTSFT 567
            .||.|.      ..|| ..|:.|:|::|.|:...  .::..||.::.|         ||..||.|
  Fly   694 SEARASLLSGDVVELSNASVVDSTSMKLTWQIIN--GKYVEGFYVYARQLPNPIVNNPAPVTSNT 756

Human   568 GPILLPGTVSSYNLSQLDPTAVYEVK--LLA-------YNQHGDG-----NATVRFVSL---RGA 615
            .|:|  |:.|:...:....:|:...|  :.|       .||.|.|     |...|.:::   .||
  Fly   757 NPLL--GSTSTSASASASASALISTKPNIAAAGKRDGETNQSGGGAPTPLNTKYRMLTILNGGGA 819

Human   616 SERT 619
            |..|
  Fly   820 SSCT 823

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
IGDCC3NP_004875.2 Ig 44..135 CDD:299845 35/96 (36%)
IG_like 48..128 CDD:214653 31/85 (36%)
Ig 143..227 CDD:299845 28/85 (33%)
IG_like 145..227 CDD:214653 28/83 (34%)
Ig 242..326 CDD:299845 28/84 (33%)
IG_like 244..326 CDD:214653 27/82 (33%)
I-set 331..417 CDD:254352 35/192 (18%)
Ig 347..414 CDD:143165 30/173 (17%)
FN3 424..517 CDD:238020 25/97 (26%)
fn3 522..603 CDD:278470 26/105 (25%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 722..743
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 762..814
robo2NP_001259868.1 Ig1_Robo 90..185 CDD:143317 36/102 (35%)
I-set 91..184 CDD:254352 35/100 (35%)
I-set 190..279 CDD:254352 29/88 (33%)
Ig2_Robo 193..279 CDD:143201 28/85 (33%)
I-set 283..370 CDD:254352 29/88 (33%)
Ig 300..370 CDD:299845 23/71 (32%)
Ig 388..>457 CDD:299845 13/68 (19%)
I-set 479..561 CDD:254352 14/81 (17%)
Ig 496..561 CDD:143165 14/64 (22%)
FN3 588..681 CDD:238020 25/94 (27%)
FN3 <817..856 CDD:238020 4/7 (57%)
fn3 864..952 CDD:278470
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG4222
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
21.810

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