DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment IGDCC3 and fra

DIOPT Version :9

Sequence 1:	NP_004875.2	Gene:	IGDCC3 / 9543	HGNCID:	9700	Length:	814	Species:	Homo sapiens
Sequence 2:	NP_523716.2	Gene:	fra / 36377	FlyBaseID:	FBgn0011592	Length:	1526	Species:	Drosophila melanogaster

Alignment Length:	1031	Identity:	219/1031 - (21%)
Similarity:	329/1031 - (31%)	Gaps:	388/1031 - (37%)

- Green bases have known domain annotations that are detailed below.

Human     6 AASPRRPPAPLWPRLLLPLLLLLLPAPSEGLGHSAELAFAVEPSDDVAVPGQPIVLDCRVEGT-- 68
            |.:..|....||..||...|:..|...|..   |..|:|.:||.|.|...|..::|.|  .||
  Fly     2 AITTNRSSRTLWNWLLSSCLIFQLIGSSLA---SQALSFTLEPQDAVVPEGHSVLLQC--AGTAS 61

Human    69 ------------PPVRITWR-KNGVEL--PESTHSTLLANGSLMIRHFRLEPGGSPSDEGDYEC- 117
                        ..|.|.|| .:|.:|  ...|..|.|.||||.|.......|.:    |.|:|
  Fly    62 IGRGGKSKSNLPSSVSIRWRGPDGQDLVIVGDTFRTQLKNGSLYISSVEENRGLT----GAYQCL 122

Human   118 VAQNRFGLVVSRKARIQAATMSDFHVHPQATVGEEGGVARFQCQI------HGLPKPLITWEKNR 176
            :.....|.::||.|.:......|.:.....|....|..|.|:|.:      .|: |..:.|.|:.
  Fly   123 LTAEGVGSILSRPALVAIVRQPDLNQDFLETYLLPGQTAYFRCMLGEANWQEGV-KHSVQWLKDD 186

Human   177 VPIDTDNERYTLLPKGVLQITGLRAEDGGIFHCVASNIASIRISHGARLTV---SGSGSGAYKEP 238
            :|:..|..|..:||.|.|:|..:...|.|.:.|..::.:|.|:|....|.:   |..|:.....|
  Fly   187 LPLPLDKLRMVVLPNGALEIDEVGPSDRGSYQCNVTSGSSSRLSSKTNLNIKKPSDPGAENSVAP 251

Human   239 AILVGPENLTLTVHQTAVLECVATGNPRPIVSWSR---------LDGRPIGVEGIQVLGTGNLII 294
            :.||||...|:....|..|:|||.|.|:|.:.|.|         ||.|      ..::|||:|.|
  Fly   252 SFLVGPSPKTVREGDTVTLDCVANGVPKPQIKWLRNGMDLDFNDLDSR------FSIVGTGSLQI 310

Human   295 SDVTVQHSGVYVCAANRPGTRVRRTAQGRLVVQAPAEFVQHPQSISRPAGTTAMFTCQAQGEPPP 359
            |......||.|.|.|:  .|.....||..:.||.|.:|::.|:..:..........|...|:|.|
  Fly   311 SSAEDIDSGNYQCRAS--NTVDSLDAQATVQVQEPPKFIKAPKDTTAHEKDEPELKCDIWGKPKP 373

Human   360 HVTWLKNGQVLGPGGHVRLKNNNSTLTISGIGPEDEAIYQCVAENSAGSSQASARLTVL------ 418
            .:.|||||.::.|..:::|.:.:: |.|.|:...|..::|||..|:|||..|:|||.|:
  Fly   374 VIRWLKNGDLITPNDYMQLVDGHN-LKILGLLNSDAGMFQCVGTNAAGSVHAAARLRVVPQGVKI 437

Human   419 ----------------------------------------------------------------- 418

  Fly   438 KKRKSQGHSTKSLQTFDNLTKRRKPFNSGEQLRTKSGGSFPFPDEDDDLDDNDSGTTRLRIPSGK 502

Human   419 ----------------------------------------------------------------W 419
                                                                            |
  Fly   503 LPKFEQPLNDRRFNILNAGSALPLDNQSKSYEDDDDDYDEDDPAKEALLEAYKQGEDAHKILDSW 567

Human   420 AEG---------------------------------------LPGPPRNVRAVSVSSTEVRVSWS 445
            .:.                                       ||..||::.|..|.|..|.:||.
  Fly   568 QQSKSKKSQQQKQSPASPDSPEQDPSVPHPGGKPLDSGLQARLPSQPRDLVAQIVKSRFVTLSWV 632

Human   446 EPLANTKEIIGYVLH------------IRKAADPPELEYQEAVSKSTFQH--------------- 483
            |||.|..:::.|.::            :.|:.|..::..|..:...|:|.
  Fly   633 EPLQNAGDVVYYTVYYKMNNSEREQKMVTKSHDDQQVNIQSLLPGRTYQFRVEANTNFGSGASSA 697

Human   484 ----------------------------------------------------------------- 483

  Fly   698 PLEVSTQPEVNIAGPPRNFEGYARSHKEIYVKWEEPTVTNGEILKYRVYYSENDSGADLYHDSTA 762

Human   484 ---LVSDLEPSTAYSFYIKAYTPRGASSASVPTLASTLGEAPAPPP--LSVRVLGSSSLQLLWEP 543
               ::::|.|.|.|...:..:...|...:|......|....|:.||  :::.|..|||:.:.|||
  Fly   763 LEAVLTELRPHTDYVISVVPFNRNGMGDSSAEIRVKTFSSTPSEPPNNVTLEVTSSSSITVHWEP 827

Human   544 WPRLAQHEG---GFKLFYR-----PASKTSFTGPILLPGTVSSYNLSQLDPTAVYEVKLLAYNQH 600
             |......|   |:|:.||     |..|::       |..:..:.||.||..|.|:||:.|...:
  Fly   828 -PAEEDRNGQITGYKIRYRKFKDAPQVKST-------PANIRYFELSNLDRNAEYQVKIAAMTVN 884

Human   601 GDGNATVRFVSLRGASERTALSPPCDCRKEEAANQTSTTG--IVIGIHIGVTCIIFCVLFLLFGQ 663
            |.|    .|.....|:           ..|...::|...|  |.|.||.|...|.     |.:|
  Fly   885 GSG----PFTEWNRAN-----------TLENDLDETQVPGKPIWISIHPGANNIA-----LHWG- 928

Human   664 RGRVLLCKDVENQLSPPQGPRSQRDPGILALNGARRGQRGQLGRDEKRVDMKELEQ 719
                           |||.|..:....:|   |..||.     .||..:::||.|:
  Fly   929 ---------------PPQHPEIKIRNYVL---GWGRGI-----PDENTIELKETER 961

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
IGDCC3	NP_004875.2	Ig	44..135	CDD:299845	32/108 (30%)
		IG_like	48..128	CDD:214653	27/97 (28%)
		Ig	143..227	CDD:299845	24/89 (27%)
		IG_like	145..227	CDD:214653	24/87 (28%)
		Ig	242..326	CDD:299845	31/92 (34%)
		IG_like	244..326	CDD:214653	29/90 (32%)
		I-set	331..417	CDD:254352	28/85 (33%)
		Ig	347..414	CDD:143165	23/66 (35%)
		FN3	424..517	CDD:238020	25/187 (13%)
		fn3	522..603	CDD:278470	29/90 (32%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	722..743
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	762..814
fra	NP_523716.2	Ig	36..140	CDD:299845	32/109 (29%)
		Ig	<180..222	CDD:299845	13/41 (32%)
		IG_like	257..340	CDD:214653	29/90 (32%)
		IGc2	264..327	CDD:197706	24/70 (34%)
		I-set	344..430	CDD:254352	28/86 (33%)
		Ig	363..428	CDD:299845	24/65 (37%)
		FN3	611..703	CDD:238020	19/91 (21%)
		FN3	711..799	CDD:238020	6/87 (7%)
		FN3	806..897	CDD:238020	31/113 (27%)
		FN3	908..989	CDD:238020	22/83 (27%)
		FN3	1011..1097	CDD:238020
		FN3	1109..1205	CDD:238020
		Neogenin_C	1273..1521	CDD:284094
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4221
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810