DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment IGDCC3 and robo3

DIOPT Version :9

Sequence 1:	NP_004875.2	Gene:	IGDCC3 / 9543	HGNCID:	9700	Length:	814	Species:	Homo sapiens
Sequence 2:	NP_608592.2	Gene:	robo3 / 33314	FlyBaseID:	FBgn0041097	Length:	1342	Species:	Drosophila melanogaster

Alignment Length:	1062	Identity:	236/1062 - (22%)
Similarity:	347/1062 - (32%)	Gaps:	362/1062 - (34%)

- Green bases have known domain annotations that are detailed below.

Human    46 VEPSDDVAVP-GQPIVLDCRVEGTPPVRITWRKNGVE---LPESTHSTLLANGSLMIR--HFRLE 104
            ||...|..|| .:|..|:|:.||:|...|.|.|:||.   ||.|...||.|.|...::  :.|.|
  Fly    26 VEHPIDTTVPRHEPATLNCKAEGSPTPTIQWYKDGVPLKILPGSHRITLPAGGLFFLKVVNSRRE 90

Human   105 PGGSPSDEGDYECVAQNRFGLVVSRKARIQAATMSD-FHVHPQATVGEEGGVARFQCQI-HGLPK 167
                 :|.|.|.|.|:|..|:..||.|.:|.|.:.| |.:.||.|...:|..|..:|.. .|:|:
  Fly    91 -----TDAGIYWCEAKNELGVARSRNATLQVAVLRDEFRLEPQNTRIAQGDTALLECAAPRGIPE 150

Human   168 PLITWEKNRVPIDTD-NERYTLLPKGVLQITGLRAEDGGIFHCVASNIASIRISHGARLTVSGSG 231
            |.:||:|....:|.: ::|..::..|.|.|...|..|.|.:.|:|.|...:|.|..|.|.|
  Fly   151 PTVTWKKGGQKLDLEGSKRVRIVDGGNLAIQDARQTDEGQYQCIAKNPVGVRESSLATLKV---- 211

Human   232 SGAYKEPAILVGPENLTLTVHQTAVLECVATGNPRPIVSWSR-LDGRPIGVEGIQVLGTGNLIIS 295
               :.:|.|:.||.:.|:....:....|...|:|.|.|.|.| ..|..:.::.:.||...:|.:.
  Fly   212 ---HVKPYIIRGPHDQTVLEGASVTFPCRVGGDPMPDVLWLRTASGGNMPLDRVSVLEDRSLRLE 273

Human   296 DVTVQHSGVYVCAANRPGTRVRRTAQGRLVVQAPAEFVQHPQSISRPAGTTAMFTCQAQGEPPPH 360
            .||:...|.|.|.|:.....:  ||.|.|.|.||.:|:|.|.|.|...|....|.|:|.|.|.|.
  Fly   274 RVTIADEGEYSCEADNVVGAI--TAMGTLTVYAPPKFIQRPASKSVELGADTSFECRAIGNPKPT 336

Human   361 VTW-LKNGQVL-GPG--------------GH-------------------------------VRL 378
            :.| :||...| .||              ||                               |:|
  Fly   337 IFWTIKNNSTLIFPGAPPLDRFHSLNTEEGHSILTLTRFQRTDKDLVILCNAMNEVASITSRVQL 401

Human   379 KNN---------------NSTLTISGIG------------------------------------- 391
            ..:               |.||.|..:.
  Fly   402 SLDSQEDRPPPIIISGPVNQTLPIKSLATLQCKAIGLPSPTISWYRDGIPVQPSSKLNITTSGDL 466

Human   392 -------PEDEAIYQCVAENSAGSSQASARLTV----------------LWAEGLPGPPRNVRA- 432
                   .:|:.:|.|||.:.||.|..|..|.:                ......||.|:.:.|
  Fly   467 IISDLDRQQDQGLYTCVASSRAGKSTWSGFLRIELPTNPNIKFYRAPEQTKCPSAPGQPKILNAT 531

Human   433 -----------------------VSVSSTEVRVSW-------SEPLANTKEI---IGYVLHIRK- 463
                                   |.:..|....:|       |||:...:.:   ..|:..:|.
  Fly   532 ASALTIVWPTSDKAGASSFLGYSVEMYCTNQSRTWIPIASRLSEPIFTVESLTQGAAYMFIVRAE 596

Human   464 ---AADPPELEYQEAV-------------SKSTFQHLVSDLEP---------------------- 490
               ...||. ...|.:             |..|.|.|:||:|.
  Fly   597 NSLGFSPPS-PISEPITAGKLVGVRDGSESTGTSQLLLSDVETLLQANDVVELLEANASDSTTAR 660

Human   491 ----------------------STAYSFYIKAYTPRGASSASVPTLAS----------------- 516
                                  |:.|.........:|.||.:||.||.
  Fly   661 LSWDIDSGQYIEGFYLYARELHSSEYKMVTLLNKGQGLSSCTVPGLAKASTYEFFLVPFYKSIVG 725

Human   517 ---------TLGEAPAPPPLSVRVL--GSSSLQLLWEPWPRLAQHEGGFKLFYRPASK------- 563
                     ||.:.|..||..:..:  ..:|:.|.|.| |:..:...|....|....|
  Fly   726 KPSNSRRMRTLEDVPEAPPYGMEAIQFNRTSVFLKWLP-PQPNRTRNGILTSYNVVVKGLDVHNT 789

Human   564 TSFTGPILLPGTVSSYNLSQLDPTAVYEVKLLAYNQHGDG--------NATVRFVSLRGASERTA 620
            |.....:.:.....:..|:.|.....|.:.:.|..:.|.|        ....|..||.....|..
  Fly   790 TRIFKNMTIDAAAPTLLLANLTTGVTYYIAVAAATRVGVGPFSKPAVLRIDARTQSLDTGYTRYP 854

Human   621 LSPPCDCRKEEAANQ--TSTTGIVIGIHIGVTCIIFCVLFLLFGQRGRVLLCKDV----ENQLSP 679
            :|       .:.|:.  |.|..||:     :..||..::|||    |.::|.|..    :..|..
  Fly   855 IS-------RDIADDFLTQTWFIVL-----LGSIIAIIVFLL----GALVLFKRYQFIKQTSLGS 903

Human   680 PQGPRS----QRDPGILALNG------------ARRGQRGQ-LGRDEKRVDMKEL---------- 717
            ..|..:    ::.| .|.|||            |..||.|. |..|......::.
  Fly   904 LHGNHAIGTVRKFP-TLPLNGGGAVGAGGSNSTAAAGQSGHGLWIDPTSGVWRQAAGGGNPGGVG 967

Human   718 -----EQLFPPASAAGQPDPRPTQDPAAPAPCEETQLSVLPLQGCGLMEGKTTEAKTTEATAPCA 777
                 |||...|.|..|...:||..|      :..:||.|.:.....:...|.::.|..|
  Fly   968 SCTTKEQLPGYAQATAQQGQQPTLLP------DYERLSPLNMPDYAEVACSTFKSPTHGA----- 1021

Human   778 GLAAAPPPPDGGPGLLSEGQAS 799
                  ||..||.|    ||::
  Fly  1022 ------PPMGGGGG----GQSA 1033

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
IGDCC3	NP_004875.2	Ig	44..135	CDD:299845	35/94 (37%)
		IG_like	48..128	CDD:214653	30/85 (35%)
		Ig	143..227	CDD:299845	27/85 (32%)
		IG_like	145..227	CDD:214653	27/83 (33%)
		Ig	242..326	CDD:299845	24/84 (29%)
		IG_like	244..326	CDD:214653	23/82 (28%)
		I-set	331..417	CDD:254352	36/191 (19%)
		Ig	347..414	CDD:143165	29/172 (17%)
		FN3	424..517	CDD:238020	31/213 (15%)
		fn3	522..603	CDD:278470	17/89 (19%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	722..743		6/20 (30%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	762..814		10/38 (26%)
robo3	NP_608592.2	Ig	22..117	CDD:299845	36/95 (38%)
		I-set	23..116	CDD:254352	35/94 (37%)
		I-set	122..211	CDD:254352	28/88 (32%)
		Ig	125..211	CDD:299845	27/85 (32%)
		I-set	215..302	CDD:254352	26/88 (30%)
		Ig	232..302	CDD:299845	21/71 (30%)
		I-set	306..401	CDD:254352	21/94 (22%)
		Ig	320..411	CDD:299845	17/90 (19%)
		I-set	412..492	CDD:254352	11/79 (14%)
		IGc2	429..489	CDD:197706	5/59 (8%)
		FN3	519..612	CDD:238020	15/93 (16%)
		FN3	644..735	CDD:238020	9/90 (10%)
		fn3	743..832	CDD:278470	17/89 (19%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4222
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810