DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment IGDCC3 and igdcc3

DIOPT Version :9

Sequence 1:	NP_004875.2	Gene:	IGDCC3 / 9543	HGNCID:	9700	Length:	814	Species:	Homo sapiens
Sequence 2:	XP_002938404.3	Gene:	igdcc3 / 100489799	XenbaseID:	XB-GENE-922404	Length:	764	Species:	Xenopus tropicalis

Alignment Length:	731	Identity:	463/731 - (63%)
Similarity:	550/731 - (75%)	Gaps:	27/731 - (3%)

- Green bases have known domain annotations that are detailed below.

Human    35 GLGHSAELAFAVEPSDDVAVPGQPIVLDCRVEGTPPVRITWRKNGVELPESTHSTLLANGSLMIR 99
            |..:|.:|.|.|||||:|||||||:.|.|..:|..|:.|.|||||..:....|:..|.||:|.|.
Frog    22 GCCYSVDLVFTVEPSDEVAVPGQPLTLFCSADGVQPITIIWRKNGSPIWNEAHALPLPNGTLYIP 86

Human   100 HFRLEPGGSPSDEGDYECVAQNRFGLVVSRKARIQAATMSDFHVHPQATVGEEGGVARFQCQIHG 164
            .|.......|||:|:|:|||.||||.|||||||:|.|.||||::.||.|..||||||||||||.|
Frog    87 LFHSVQEDEPSDQGEYDCVAHNRFGSVVSRKARVQTAVMSDFYIFPQDTTLEEGGVARFQCQIRG 151

Human   165 LPKPLITWEKNRVPIDTDNERYTLLPKGVLQITGLRAEDGGIFHCVASNIASIRISHGARLTVSG 229
            ||:|.|.||:|...|||:|.||||||.||||||.||:||.|.:.|||:|.|.::.|..|.|.|:.
Frog   152 LPEPEIVWERNGEMIDTENLRYTLLPTGVLQITALRSEDTGTYRCVATNAAGVKYSPSATLIVTD 216

Human   230 SGSGAYKEPAILVGPENLTLTVHQTAVLECVATGNPRPIVSWSRLDGRPIGVEGIQVLGTGNLII 294
            |.|..||:|.|||||||||.||||||:|||:||||||||||||||||||||||||||:|.|||:|
Frog   217 SHSTGYKDPMILVGPENLTKTVHQTAILECMATGNPRPIVSWSRLDGRPIGVEGIQVVGNGNLMI 281

Human   295 SDVTVQHSGVYVCAANRPGTRVRRTAQGRLVVQAPAEFVQHPQSISRPAGTTAMFTCQAQGEPPP 359
            ||:||.||||||||||:||||||||||||||||||||||||||||:||.||||:|||.|||||||
Frog   282 SDLTVHHSGVYVCAANKPGTRVRRTAQGRLVVQAPAEFVQHPQSITRPVGTTAIFTCLAQGEPPP 346

Human   360 HVTWLKNGQVLGPGGHVRLKNNNSTLTISGIGPEDEAIYQCVAENSAGSSQASARLTVLWAEGLP 424
            .:|||||||.|.|.||::||||||:||||||..||||||||||:||||||||||||:||||||||
Frog   347 QITWLKNGQELEPSGHIKLKNNNSSLTISGISQEDEAIYQCVAKNSAGSSQASARLSVLWAEGLP 411

Human   425 GPPRNVRAVSVSSTEVRVSWSEPLANTKEIIGYVLHIRKAADPPELEYQEAVSKSTFQHLVSDLE 489
            |||:::||.:.|||.:.||||:||.||:||||||:||||.|||.::||||||||.|||.||:|||
Frog   412 GPPQDIRATTASSTSIHVSWSKPLENTREIIGYVVHIRKTADPIQMEYQEAVSKDTFQQLVTDLE 476

Human   490 PSTAYSFYIKAYTPRGASSASVPTLASTLGEAPAPPPLSVRVLGSSSLQLLWEPWPRLAQHEGGF 554
            |||.|||||||||.||||.||.....|||||.||.|.|.::||.|:::|..|||..:|.|:| ||
Frog   477 PSTTYSFYIKAYTSRGASKASANVQQSTLGEVPAVPSLYIKVLNSTAIQAAWEPSIKLGQNE-GF 540

Human   555 KLFYRPASKTSFTGPILLPGTVSSYNLSQLDPTAVYEVKLLAYNQHGDGNATVRFVSLRGASERT 619
            ||:||......:|||:|||..|::||:|:|||..||||||||:|||||||:|||||||:.||.|.
Frog   541 KLYYRKVPTPDYTGPMLLPSNVTAYNISRLDPLVVYEVKLLAFNQHGDGNSTVRFVSLKEASARA 605

Human   620 ALSPPCDCRKEEAANQTSTTGIVIGIHIGVTCIIFCVLFLLFGQRGRVLLCKDVENQLSPPQGPR 684
            .|:|.|:|..:|...::|||||:||||||||||||||:||:||.|||::.||.|:.|.|.|| |.
Frog   606 VLNPSCNCVSDEQRPKSSTTGIIIGIHIGVTCIIFCVIFLIFGYRGRLMKCKSVQEQRSVPQ-PT 669

Human   685 SQRDPGILALNGARRGQRGQL-------GRDEKRVDMKELEQLFPPASAAGQPDPRPTQD----- 737
            |....  ..:.||  .|.|.|       |..:|..|:.|:|.|||..|        |.||
Frog   670 SAGSG--RTMEGA--SQNGTLLRGNEAPGSKDKVSDLNEMEHLFPHTS--------PHQDGSTLC 722

Human   738 -PAAPAPCEETQLSVL 752
             |.:|...::|.:|.:
Frog   723 PPVSPPTVDKTLVSTI 738

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
IGDCC3	NP_004875.2	Ig	44..135	CDD:299845	49/90 (54%)
		IG_like	48..128	CDD:214653	40/79 (51%)
		Ig	143..227	CDD:299845	52/83 (63%)
		IG_like	145..227	CDD:214653	52/81 (64%)
		Ig	242..326	CDD:299845	74/83 (89%)
		IG_like	244..326	CDD:214653	72/81 (89%)
		I-set	331..417	CDD:254352	70/85 (82%)
		Ig	347..414	CDD:143165	53/66 (80%)
		FN3	424..517	CDD:238020	64/92 (70%)
		fn3	522..603	CDD:278470	45/80 (56%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	722..743		7/26 (27%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	762..814
igdcc3	XP_002938404.3	Ig strand B	334..341	CDD:409353	4/6 (67%)
		Ig strand C	347..352	CDD:409353	2/4 (50%)
		Ig strand C'	354..357	CDD:409353	2/2 (100%)
		Ig strand E	369..376	CDD:409353	5/6 (83%)
		Ig strand F	383..391	CDD:409353	7/7 (100%)
		Ig strand G	394..404	CDD:409353	9/9 (100%)
		FN3	411..504	CDD:238020	64/92 (70%)
		fn3	509..589	CDD:394996	45/80 (56%)
		Ig	29..121	CDD:416386	50/91 (55%)
		Ig strand A'	34..40	CDD:409353	4/5 (80%)
		Ig strand B	44..54	CDD:409353	4/9 (44%)
		Ig strand C	58..64	CDD:409353	2/5 (40%)
		Ig strand C'	66..69	CDD:409353	1/2 (50%)
		Ig strand E	81..87	CDD:409353	3/5 (60%)
		Ig strand F	100..107	CDD:409353	4/6 (67%)
		Ig strand G	111..121	CDD:409353	8/9 (89%)
		Ig	132..214	CDD:416386	52/81 (64%)
		Ig strand A'	134..138	CDD:409353	1/3 (33%)
		Ig strand B	142..149	CDD:409353	6/6 (100%)
		Ig strand C	156..161	CDD:409353	2/4 (50%)
		Ig strand C'	163..166	CDD:409353	0/2 (0%)
		Ig strand D	172..176	CDD:409353	3/3 (100%)
		Ig strand E	179..185	CDD:409353	5/5 (100%)
		Ig strand F	192..200	CDD:409353	4/7 (57%)
		Ig strand G	203..214	CDD:409353	3/10 (30%)
		Ig strand A	226..229	CDD:409353	1/2 (50%)
		IG_like	231..308	CDD:214653	67/76 (88%)
		Ig strand A'	233..236	CDD:409353	2/2 (100%)
		Ig strand B	242..249	CDD:409353	4/6 (67%)
		Ig strand C	255..260	CDD:409353	4/4 (100%)
		Ig strand C'	263..265	CDD:409353	1/1 (100%)
		Ig strand D	271..274	CDD:409353	2/2 (100%)
		Ig strand E	277..282	CDD:409353	3/4 (75%)
		Ig strand F	290..298	CDD:409353	7/7 (100%)
		I-set	318..404	CDD:400151	70/85 (82%)
		Ig strand A'	321..327	CDD:409353	5/5 (100%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	152	1.000	Domainoid score	I20971
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H3590
Inparanoid	1	1.050	914	1.000	Inparanoid score	I3618
NCBI	1	1.000	-	-
OMA	1	1.010	-	-		QHG51493
OrthoDB	1	1.010	-	-		D1010015at2759
OrthoFinder	1	1.000	-	-		FOG0010673
OrthoInspector	1	1.000	-	-		oto152182
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X8166
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	12	11.980