DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment NRG2 and Nrg2

DIOPT Version :9

Sequence 1:	NP_053585.1	Gene:	NRG2 / 9542	HGNCID:	7998	Length:	858	Species:	Homo sapiens
Sequence 2:	NP_001129623.2	Gene:	Nrg2 / 432361	RGDID:	1303302	Length:	860	Species:	Rattus norvegicus

Alignment Length:	875	Identity:	810/875 - (92%)
Similarity:	820/875 - (93%)	Gaps:	32/875 - (3%)

- Green bases have known domain annotations that are detailed below.

Human     1 MRQVCCSALPPPPLEKGRCSSYS---DSSSSSSERSSSSSSSSSESGSSSRSS------------ 50
            ||||||||| ||||||.||||||   .||||||..||||:||.|.|.||||||
  Rat     1 MRQVCCSAL-PPPLEKARCSSYSYSDSSSSSSSNNSSSSTSSRSSSRSSSRSSRGSTTTTSSSEN 64

Human    51 --SNNSSISRPAAPPEPRPQQQPQPRSPAARRAAARSRAAAAGGMRRDPAPGFSMLLFGVSLACY 113
              ||:.||.|||||||||||.||||||||||||||||||||||||||||||||||||||||||||
  Rat    65 SGSNSGSIFRPAAPPEPRPQPQPQPRSPAARRAAARSRAAAAGGMRRDPAPGFSMLLFGVSLACY 129

Human   114 SPSLKSVQDQAYKAPVVVEGKVQGLVPAGGSSSNSTREPPASGRVALVKVLDKWPLRSGGLQREQ 178
            |||||||||||||||||||||||||.|||||||||||||||||||||||||||||||||||||||
  Rat   130 SPSLKSVQDQAYKAPVVVEGKVQGLAPAGGSSSNSTREPPASGRVALVKVLDKWPLRSGGLQREQ 194

Human   179 VISVGSCVPLERNQRYIFFLEPTEQPLVFKTAFAPLDTNGKNLKKEVGKILCTDCATRPKLKKMK 243
            |||||||.|||||||||||||||||||||||||||:|.||||:||||||||||||||||||||||
  Rat   195 VISVGSCAPLERNQRYIFFLEPTEQPLVFKTAFAPVDPNGKNIKKEVGKILCTDCATRPKLKKMK 259

Human   244 SQTGQVGEKQSLKCEAAAGNPQPSYRWFKDGKELNRSRDIRIKYGNGRKNSRLQFNKVKVEDAGE 308
            ||||:||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
  Rat   260 SQTGEVGEKQSLKCEAAAGNPQPSYRWFKDGKELNRSRDIRIKYGNGRKNSRLQFNKVKVEDAGE 324

Human   309 YVCEAENILGKDTVRGRLYVNSVSTTLSSWSGHARKCNETAKSYCVNGGVCYYIEGINQLSCKCP 373
            ||||||||||||||||||:||||||||||||||||||||||||||||||||||||||||||||||
  Rat   325 YVCEAENILGKDTVRGRLHVNSVSTTLSSWSGHARKCNETAKSYCVNGGVCYYIEGINQLSCKCP 389

Human   374 NGFFGQRCLEKLPLRLYMPDPKQKHLGFELKEAEELYQKRVLTITGICVALLVVGIVCVVAYCKT 438
            ||||||||||||||||||||||||        |||||||||||||||||||||||||||||||||
  Rat   390 NGFFGQRCLEKLPLRLYMPDPKQK--------AEELYQKRVLTITGICVALLVVGIVCVVAYCKT 446

Human   439 KKQRKQMHNHLRQNMCPAHQNRSLANGPSHPRLDPEEIQMADYISKNVPATDHVIRRETETTFSG 503
            ||||:|||:|||||||||||||||||||||||||||||||||||||||||||||||||.||||||
  Rat   447 KKQRRQMHHHLRQNMCPAHQNRSLANGPSHPRLDPEEIQMADYISKNVPATDHVIRREAETTFSG 511

Human   504 SHSCSPSHHCSTATPTSSHRHESHTWSLERSESLTSDSQSGIMLSSVGTSKCNSPACVEARARRA 568
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
  Rat   512 SHSCSPSHHCSTATPTSSHRHESHTWSLERSESLTSDSQSGIMLSSVGTSKCNSPACVEARARRA 576

Human   569 AAYNLEERRRATAPPYHDSVDSLRDSPHSERYVSALTTPARLSPVDFHYSLATQVPTFEITSPNS 633
            |||:.||||||..||||||:|||||||||||||||||||||||||||||||||||||||||||||
  Rat   577 AAYSQEERRRAAMPPYHDSIDSLRDSPHSERYVSALTTPARLSPVDFHYSLATQVPTFEITSPNS 641

Human   634 AHAVSLPPAAPISYRLAEQQPLLRHPAPPGPGPGPGPGPGPGADMQRSYDSYYYPAAGPGPRRGT 698
            ||||||||||||||||||||||||||||      ||||||||||||||||||||||||||||||.
  Rat   642 AHAVSLPPAAPISYRLAEQQPLLRHPAP------PGPGPGPGADMQRSYDSYYYPAAGPGPRRGA 700

Human   699 CALGGSLGSLPASPFRIPEDDEYETTQECAPPPPPRPRARGASRRTSAGPRRWRRSRLNGLAAQR 763
            ||||||||||||||||||||||||||||||||||||||.||||||||||||||||||||||||||
  Rat   701 CALGGSLGSLPASPFRIPEDDEYETTQECAPPPPPRPRTRGASRRTSAGPRRWRRSRLNGLAAQR 765

Human   764 ARAARDSLSLSSGSGGGSASASDDDADDADGALAAESTPFLGLRGAHDALRSDSPPLCPAADSRT 828
            |||||||||||||||.||||||||||||||||||||||||||||.||||||||||||||||||||
  Rat   766 ARAARDSLSLSSGSGCGSASASDDDADDADGALAAESTPFLGLRAAHDALRSDSPPLCPAADSRT 830

Human   829 YYSLDSHSTRASSRHSRGPPPRAKQDSAPL 858
            ||||||||||||||||||||.||||||.||
  Rat   831 YYSLDSHSTRASSRHSRGPPTRAKQDSGPL 860

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
NRG2	NP_053585.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..96		81/111 (73%)
		I-set	239..328	CDD:254352	87/88 (99%)
		Ig_Pro_neuregulin	253..326	CDD:143227	72/72 (100%)
		PHA02887	<343..383	CDD:165214	39/39 (100%)
		Neuregulin	406..845	CDD:280343	420/438 (96%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	500..543		42/42 (100%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	574..593		15/18 (83%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	655..689		27/33 (82%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	708..796		85/87 (98%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	809..858		46/48 (96%)
Nrg2	NP_001129623.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..114		83/113 (73%)
		IG	259..344	CDD:214652	83/84 (99%)
		EGF_CA	<369..397	CDD:238011	27/27 (100%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	461..480		18/18 (100%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	508..545		36/36 (100%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	663..682		18/24 (75%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	712..798		83/85 (98%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	815..860		42/44 (95%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C83692462
Domainoid	1	1.000	783	1.000	Domainoid score	I2794
eggNOG	0	0.000	Not matched by this tool.
HGNC	1	1.500	-	-
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H75024
Inparanoid	1	1.050	1611	1.000	Inparanoid score	I2370
NCBI	1	1.000	-	-
OMA	1	1.010	-	-		QHG41133
OrthoDB	1	1.010	-	-		D126039at7742
OrthoFinder	1	1.000	-	-		FOG0005044
OrthoInspector	1	1.000	-	-		oto131071
orthoMCL	1	0.900	-	-		OOG6_116372
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X2572
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	15	15.310