Protein Alignment NRG2 and Nrg2

DIOPT Version :10

• Sequence 1: NP_053585.1
• Gene: NRG2 / 9542
• HGNCID: 7998
• Length: 858
• Species: Homo sapiens
• Sequence 2: XP_063133571.1
• Gene: Nrg2 / 432361
• RGDID: 1303302
• Length: 862
• Species: Rattus norvegicus
• Alignment Length: 875
• Identity: 799/875 - (91%)
• Similarity: 812/875 - (92%)
• Gaps: 30/875 - (3%)

Human     1 MRQVCCSALPPPPLEKGRCSSYS---DSSSSSSERSSSSSSSSSESGSSSRSS------------ 50
            ||||||||| ||||||.||||||   .||||||..||||:||.|.|.||||||
  Rat     1 MRQVCCSAL-PPPLEKARCSSYSYSDSSSSSSSNNSSSSTSSRSSSRSSSRSSRGSTTTTSSSEN 64

Human    51 --SNNSSISRPAAPPEPRPQQQPQPRSPAARRAAARSRAAAAGGMRRDPAPGFSMLLFGVSLACY 113
              ||:.||.|||||||||||.||||||||||||||||||||||||||||||||||||||||||||
  Rat    65 SGSNSGSIFRPAAPPEPRPQPQPQPRSPAARRAAARSRAAAAGGMRRDPAPGFSMLLFGVSLACY 129

Human   114 SPSLKSVQDQAYKAPVVVEGKVQGLVPAGGSSSNSTREPPASGRVALVKVLDKWPLRSGGLQREQ 178
            |||||||||||||||||||||||||.|||||||||||||||||||||||||||||||||||||||
  Rat   130 SPSLKSVQDQAYKAPVVVEGKVQGLAPAGGSSSNSTREPPASGRVALVKVLDKWPLRSGGLQREQ 194

Human   179 VISVGSCVPLERNQRYIFFLEPTEQPLVFKTAFAPLDTNGKNLKKEVGKILCTDCATRPKLKKMK 243
            |||||||.|||||||||||||||||||||||||||:|.||||:||||||||||||||||||||||
  Rat   195 VISVGSCAPLERNQRYIFFLEPTEQPLVFKTAFAPVDPNGKNIKKEVGKILCTDCATRPKLKKMK 259

Human   244 SQTGQVGEKQSLKCEAAAGNPQPSYRWFKDGKELNRSRDIRIKYGNGRKNSRLQFNKVKVEDAGE 308
            ||||:||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
  Rat   260 SQTGEVGEKQSLKCEAAAGNPQPSYRWFKDGKELNRSRDIRIKYGNGRKNSRLQFNKVKVEDAGE 324

Human   309 YVCEAENILGKDTVRGRLYVNSVSTTLSSWSGHARKCNETAKSYCVNGGVCYYIEGINQLSCKCP 373
            ||||||||||||||||||:||||||||||||||||||||||||||||||||||||||||||||||
  Rat   325 YVCEAENILGKDTVRGRLHVNSVSTTLSSWSGHARKCNETAKSYCVNGGVCYYIEGINQLSCKCP 389

Human   374 NGFFGQRCLEKLPLRLYMPDPKQKHLGFELKEAEELYQKRVLTITGICVALLVVGIVCVVAYCKT 438
            .|:.|.||.:...:..      .||||||||||||||||||||||||||||||||||||||||||
  Rat   390 VGYTGDRCQQFAMVNF------SKHLGFELKEAEELYQKRVLTITGICVALLVVGIVCVVAYCKT 448

Human   439 KKQRKQMHNHLRQNMCPAHQNRSLANGPSHPRLDPEEIQMADYISKNVPATDHVIRRETETTFSG 503
            ||||:|||:|||||||||||||||||||||||||||||||||||||||||||||||||.||||||
  Rat   449 KKQRRQMHHHLRQNMCPAHQNRSLANGPSHPRLDPEEIQMADYISKNVPATDHVIRREAETTFSG 513

Human   504 SHSCSPSHHCSTATPTSSHRHESHTWSLERSESLTSDSQSGIMLSSVGTSKCNSPACVEARARRA 568
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
  Rat   514 SHSCSPSHHCSTATPTSSHRHESHTWSLERSESLTSDSQSGIMLSSVGTSKCNSPACVEARARRA 578

Human   569 AAYNLEERRRATAPPYHDSVDSLRDSPHSERYVSALTTPARLSPVDFHYSLATQVPTFEITSPNS 633
            |||:.||||||..||||||:|||||||||||||||||||||||||||||||||||||||||||||
  Rat   579 AAYSQEERRRAAMPPYHDSIDSLRDSPHSERYVSALTTPARLSPVDFHYSLATQVPTFEITSPNS 643

Human   634 AHAVSLPPAAPISYRLAEQQPLLRHPAPPGPGPGPGPGPGPGADMQRSYDSYYYPAAGPGPRRGT 698
            ||||||||||||||||||||||||||||      ||||||||||||||||||||||||||||||.
  Rat   644 AHAVSLPPAAPISYRLAEQQPLLRHPAP------PGPGPGPGADMQRSYDSYYYPAAGPGPRRGA 702

Human   699 CALGGSLGSLPASPFRIPEDDEYETTQECAPPPPPRPRARGASRRTSAGPRRWRRSRLNGLAAQR 763
            ||||||||||||||||||||||||||||||||||||||.||||||||||||||||||||||||||
  Rat   703 CALGGSLGSLPASPFRIPEDDEYETTQECAPPPPPRPRTRGASRRTSAGPRRWRRSRLNGLAAQR 767

Human   764 ARAARDSLSLSSGSGGGSASASDDDADDADGALAAESTPFLGLRGAHDALRSDSPPLCPAADSRT 828
            |||||||||||||||.||||||||||||||||||||||||||||.||||||||||||||||||||
  Rat   768 ARAARDSLSLSSGSGCGSASASDDDADDADGALAAESTPFLGLRAAHDALRSDSPPLCPAADSRT 832

Human   829 YYSLDSHSTRASSRHSRGPPPRAKQDSAPL 858
            ||||||||||||||||||||.||||||.||
  Rat   833 YYSLDSHSTRASSRHSRGPPTRAKQDSGPL 862

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
NRG2	NP_053585.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..96		81/111 (73%)
		Ig_Pro_neuregulin	237..328	CDD:409408	89/90 (99%)
		putative Ig strand A	237..243	CDD:409408	5/5 (100%)
		Ig strand B	253..257	CDD:409408	3/3 (100%)
		Ig strand C	267..271	CDD:409408	3/3 (100%)
		Ig strand E	294..298	CDD:409408	3/3 (100%)
		Ig strand F	308..313	CDD:409408	4/4 (100%)
		Ig strand G	321..324	CDD:409408	2/2 (100%)
		Neuregulin	438..839	CDD:426627	382/400 (96%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	500..543		42/42 (100%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	574..593		15/18 (83%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	655..689		27/33 (82%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	708..796		85/87 (98%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	809..858		46/48 (96%)
Nrg2	XP_063133571.1	None