DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment NRG2 and vn

DIOPT Version :9

Sequence 1:	NP_053585.1	Gene:	NRG2 / 9542	HGNCID:	7998	Length:	858	Species:	Homo sapiens
Sequence 2:	NP_523942.2	Gene:	vn / 38657	FlyBaseID:	FBgn0003984	Length:	623	Species:	Drosophila melanogaster

Alignment Length:	589	Identity:	136/589 - (23%)
Similarity:	186/589 - (31%)	Gaps:	254/589 - (43%)

- Green bases have known domain annotations that are detailed below.

Human    12 PPLEKGRCSSYSDSSSSSSERSSSSSSSSSESG-SSSRSSSNN--------------SSIS---- 57
            |.|.:|.....|.....||:..|.||.||:||| |||||||||              :|:|
  Fly    56 PRLWEGSAEESSYYIPLSSDNGSGSSESSAESGSSSSRSSSNNIDNNILSRLLSLNSNSLSSRSN 120

Human    58 ---RP------------------AAPPEPRPQQQPQPRS-------------------------- 75
               :|                  ||.||.:.|||.|.:|
  Fly   121 VKLKPATVFDAGSSTPAQQEQHVAAVPEQQQQQQQQQQSMQKVPNTLINSQIYNLLYNGMPSEAA 185

Human    76 ------------------------------PAAR-------------------RAAARSR--AAA 89
                                          ||.|                   ..|||||  .:.
  Fly   186 SSKMRRHIQPSQLPHQPESRAQLPSNYSSRPAVRSYLIESYEMPESMLEDRSPEQAARSRRDGSN 250

Human    90 AGGMRRDPAPGFSMLLFGVSLACYSPSLKSVQDQ------------------------------- 123
            ..|.|:....|....|    ........:..|||
  Fly   251 TNGSRQQQRTGHRQQL----QQDKRDHRRQRQDQQKEQRQQQQQRQHKSGNKHQQQQQQRRKHQR 311

Human   124 -----------------AYKAPVVVEG-----------------KVQ------------GLVPAG 142
                             |:.||.|.:|                 ||:            .||...
  Fly   312 KHQRYNRYCSARDPAQLAFAAPTVFQGVFKSMSADRRVNFSATMKVEKVYKQQHDLQLPTLVRLQ 376

Human   143 GSSSNSTREPPASGRVALVKVLDKWPLRSGG-LQREQVISVGSCVPLERNQRYIFFLEPTE---- 202
            .:.|||:.|..    :...:::.:..||||. ||:...||            |:.|::.|.
  Fly   377 FALSNSSGECD----IYRERLMPRGMLRSGNDLQQASDIS------------YMMFVQQTNPGNF 425

Human   203 ----QP-----LVFKTAFAPLDTNGKNLKKEVGKILCTDCATRPKLKKMKSQTGQVGEKQSLKCE 258
                ||     ||.:.....:..| .....||.||.     ::|....:|.     |:|..:.||
  Fly   426 TILGQPMRVTHLVVEAVETAVSEN-YTQNAEVTKIF-----SKPSKAIIKH-----GKKLRIVCE 479

Human   259 AAAGNPQPSYRWFKDGKELNRSRDIRIKYGNGRKNSRL---QFNKVKVEDAGEYVCEAENILGKD 320
             .:|.|.|...||||.|.:||.|:| .::.:.::.|.|   .||  ...|||.|.|.|:|...|.
  Fly   480 -VSGQPPPKVTWFKDEKSINRKRNI-YQFKHHKRRSELIVRSFN--SSSDAGRYECRAKNKASKA 540

Human   321 TVRGRLYVNSVST---TLSSWSGHARKCNETAKSYCVNGGVCYYIEGINQLSCKCPNGFFGQRCL 382
            ..:.|:.:.:...   |..|.||  ..||   ..||.:.|.|..|..||::.|:||..:||.||.
  Fly   541 IAKRRIMIKASPVHFPTDRSASG--IPCN---FDYCFHNGTCRMIPDINEVYCRCPTEYFGNRCE 600

Human   383 EKLP 386
            .|.|
  Fly   601 NKWP 604

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
NRG2	NP_053585.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..96		45/200 (23%)
		I-set	239..328	CDD:254352	30/91 (33%)
		Ig_Pro_neuregulin	253..326	CDD:143227	26/75 (35%)
		PHA02887	<343..383	CDD:165214	16/39 (41%)
		Neuregulin	406..845	CDD:280343
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	500..543
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	574..593
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	655..689
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	708..796
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	809..858
vn	NP_523942.2	IGc2	471..538	CDD:197706	27/70 (39%)
vn	NP_523942.2	EGF	566..598	CDD:278437	14/34 (41%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_28J9V
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm40289
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R8848
SonicParanoid	1	1.000	-	-		X2572
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	5	4.840