DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment NRG2 and igcm-4

DIOPT Version :9

Sequence 1:	NP_053585.1	Gene:	NRG2 / 9542	HGNCID:	7998	Length:	858	Species:	Homo sapiens
Sequence 2:	NP_508377.1	Gene:	igcm-4 / 180518	WormBaseID:	WBGene00022418	Length:	541	Species:	Caenorhabditis elegans

Alignment Length:	200	Identity:	51/200 - (25%)
Similarity:	81/200 - (40%)	Gaps:	47/200 - (23%)

- Green bases have known domain annotations that are detailed below.

Human   237 PKLKKMKSQTG-QVGEKQ-SLKCEAAAGNPQPS-YRWFKDGKELNRSRDIRIKYGNGRKNSRLQF 298
            |:::.::::.. .:|:|| .|.|...|.....: .:|.|:|::|    |...:|...:.:..|:.
Worm    34 PRMRNVETKFRIPLGQKQFRLVCPIIATEKDSTMIQWSKNGEQL----DWDSQYKLSKDSKELKM 94

Human   299 NKVKVEDAGEYVCEAENILGKDTVRGRLYV-------NSV------STTLSSWSGHARKCNETAK 350
            ..||.||:|.|.|:|.|..|..|:...::|       |||      |.|.:|.|......:|...
Worm    95 KSVKFEDSGRYQCQATNGFGHKTIEFIVHVHDQHDKENSVKDYLVLSNTTASPSWLIDMNSEWRS 159

Human   351 SYCVNGGVCYYIEGINQLSCKCP-NGFFGQRCLEKLP-LRLYMPDPKQKHLGFELKEAEELYQKR 413
            ...:|.|        .:|..:|| .|       ..|| :|.|..:          .|..|...|.
Worm   160 PIKINTG--------GKLELRCPAQG-------NPLPEIRWYQNE----------MEISEKTHKH 199

Human   414 VLTIT 418
            |.|||
Worm   200 VSTIT 204

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
NRG2	NP_053585.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..96
		I-set	239..328	CDD:254352	24/91 (26%)
		Ig_Pro_neuregulin	253..326	CDD:143227	22/74 (30%)
		PHA02887	<343..383	CDD:165214	7/40 (18%)
		Neuregulin	406..845	CDD:280343	5/12 (42%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	500..543
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	574..593
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	655..689
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	708..796
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	809..858
igcm-4	NP_508377.1	IGc2	52..114	CDD:197706	19/65 (29%)
		I-set	159..235	CDD:254352	16/70 (23%)
		IGc2	166..225	CDD:197706	15/63 (24%)
		IG_like	261..373	CDD:214653
		Ig	269..374	CDD:299845
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910