DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment NRG2 and Nrg2

DIOPT Version :9

Sequence 1:	NP_053585.1	Gene:	NRG2 / 9542	HGNCID:	7998	Length:	858	Species:	Homo sapiens
Sequence 2:	NP_001369349.1	Gene:	Nrg2 / 100042150	MGIID:	1098246	Length:	859	Species:	Mus musculus

Alignment Length:	870	Identity:	796/870 - (91%)
Similarity:	813/870 - (93%)	Gaps:	23/870 - (2%)

- Green bases have known domain annotations that are detailed below.

Human     1 MRQVCCSALPPPPLEKGRCS----SYSDSSSSSSERSSSSSSSSSESGSSSRSSSN--------N 53
            ||||||||| ||||||.|||    ||||||||::..|.|||||||.:.|||.|||:        :
Mouse     1 MRQVCCSAL-PPPLEKARCSSYSYSYSDSSSSTTSSSRSSSSSSSRNSSSSNSSSSESSGSNSGS 64

Human    54 SSISRPAAPPEPRPQQQPQPRSPAARRAAARSRAAAAGGMRRDPAPGFSMLLFGVSLACYSPSLK 118
            |||.|||||||||||.|||||||||||||||||||||||||||||||||||||||||||||||||
Mouse    65 SSIFRPAAPPEPRPQPQPQPRSPAARRAAARSRAAAAGGMRRDPAPGFSMLLFGVSLACYSPSLK 129

Human   119 SVQDQAYKAPVVVEGKVQGLVPAGGSSSNSTREPPASGRVALVKVLDKWPLRSGGLQREQVISVG 183
            ||||||||||||||||||||.||||||||||||||||||||||||||||||||||||||||||||
Mouse   130 SVQDQAYKAPVVVEGKVQGLAPAGGSSSNSTREPPASGRVALVKVLDKWPLRSGGLQREQVISVG 194

Human   184 SCVPLERNQRYIFFLEPTEQPLVFKTAFAPLDTNGKNLKKEVGKILCTDCATRPKLKKMKSQTGQ 248
            ||.|||||||||||||||||||||||||||:|.||||:||||||||||||||||||||||||||:
Mouse   195 SCAPLERNQRYIFFLEPTEQPLVFKTAFAPVDPNGKNIKKEVGKILCTDCATRPKLKKMKSQTGE 259

Human   249 VGEKQSLKCEAAAGNPQPSYRWFKDGKELNRSRDIRIKYGNGRKNSRLQFNKVKVEDAGEYVCEA 313
            |||||||||||||||||||||||||||||||||||||||||||||||||||||:|||||||||||
Mouse   260 VGEKQSLKCEAAAGNPQPSYRWFKDGKELNRSRDIRIKYGNGRKNSRLQFNKVRVEDAGEYVCEA 324

Human   314 ENILGKDTVRGRLYVNSVSTTLSSWSGHARKCNETAKSYCVNGGVCYYIEGINQLSCKCPNGFFG 378
            |||||||||||||:||||||||||||||||||||||||||||||||||||||||||||||.|:.|
Mouse   325 ENILGKDTVRGRLHVNSVSTTLSSWSGHARKCNETAKSYCVNGGVCYYIEGINQLSCKCPVGYTG 389

Human   379 QRCLEKLPLRLYMPDPKQKHLGFELKEAEELYQKRVLTITGICVALLVVGIVCVVAYCKTKKQRK 443
            .||.:...:..      .||||||||||||||||||||||||||||||||||||||||||||||:
Mouse   390 DRCQQFAMVNF------SKHLGFELKEAEELYQKRVLTITGICVALLVVGIVCVVAYCKTKKQRR 448

Human   444 QMHNHLRQNMCPAHQNRSLANGPSHPRLDPEEIQMADYISKNVPATDHVIRRETETTFSGSHSCS 508
            |||:|||||||||||||||||||||||||||||||||||||||||||||||||.|||||||||||
Mouse   449 QMHHHLRQNMCPAHQNRSLANGPSHPRLDPEEIQMADYISKNVPATDHVIRREAETTFSGSHSCS 513

Human   509 PSHHCSTATPTSSHRHESHTWSLERSESLTSDSQSGIMLSSVGTSKCNSPACVEARARRAAAYNL 573
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||:.
Mouse   514 PSHHCSTATPTSSHRHESHTWSLERSESLTSDSQSGIMLSSVGTSKCNSPACVEARARRAAAYSQ 578

Human   574 EERRRATAPPYHDSVDSLRDSPHSERYVSALTTPARLSPVDFHYSLATQVPTFEITSPNSAHAVS 638
            ||||||..||||||:||||||||||||||||||||||||||||||||||||||||||||||||||
Mouse   579 EERRRAAMPPYHDSIDSLRDSPHSERYVSALTTPARLSPVDFHYSLATQVPTFEITSPNSAHAVS 643

Human   639 LPPAAPISYRLAEQQPLLRHPAPPGPGPGPGPGPGPGADMQRSYDSYYYPAAGPGPRRGTCALGG 703
            |||||||||||||||||||||||    ||||||.||||||||||||||||||||||||..|||||
Mouse   644 LPPAAPISYRLAEQQPLLRHPAP----PGPGPGSGPGADMQRSYDSYYYPAAGPGPRRSACALGG 704

Human   704 SLGSLPASPFRIPEDDEYETTQECAPPPPPRPRARGASRRTSAGPRRWRRSRLNGLAAQRARAAR 768
            |||||||||||||||||||||||||||||||||.|||||||||||||||||||||||||||||||
Mouse   705 SLGSLPASPFRIPEDDEYETTQECAPPPPPRPRTRGASRRTSAGPRRWRRSRLNGLAAQRARAAR 769

Human   769 DSLSLSSGSGGGSASASDDDADDADGALAAESTPFLGLRGAHDALRSDSPPLCPAADSRTYYSLD 833
            ||||||||||.||||||||||||||||||||||||||||.|||||||||||||||||||||||||
Mouse   770 DSLSLSSGSGCGSASASDDDADDADGALAAESTPFLGLRAAHDALRSDSPPLCPAADSRTYYSLD 834

Human   834 SHSTRASSRHSRGPPPRAKQDSAPL 858
            |||||||||||||||.||||||.||
Mouse   835 SHSTRASSRHSRGPPTRAKQDSGPL 859

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
NRG2	NP_053585.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..96		79/106 (75%)
		I-set	239..328	CDD:254352	86/88 (98%)
		Ig_Pro_neuregulin	253..326	CDD:143227	71/72 (99%)
		PHA02887	<343..383	CDD:165214	35/39 (90%)
		Neuregulin	406..845	CDD:280343	420/438 (96%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	500..543		42/42 (100%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	574..593		15/18 (83%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	655..689		28/33 (85%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	708..796		85/87 (98%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	809..858		46/48 (96%)
Nrg2	NP_001369349.1	Ig_Pro_neuregulin	248..339	CDD:409408	88/90 (98%)
		Ig strand B	264..268	CDD:409408	3/3 (100%)
		Ig strand C	278..282	CDD:409408	3/3 (100%)
		Ig strand E	305..309	CDD:409408	3/3 (100%)
		Ig strand F	319..324	CDD:409408	4/4 (100%)
		Ig strand G	332..335	CDD:409408	2/2 (100%)
		PHA02887	<354..397	CDD:165214	35/42 (83%)
		Neuregulin	443..840	CDD:396641	382/400 (96%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C83969133
Domainoid	1	1.000	784	1.000	Domainoid score	I2983
eggNOG	1	0.900	-	-		E1_28J9V
HGNC	1	1.500	-	-
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H75024
Inparanoid	1	1.050	1441	1.000	Inparanoid score	I3247
Isobase	0	0.000	Not matched by this tool.
NCBI	1	1.000	-	-
OMA	1	1.010	-	-		QHG41133
OrthoDB	1	1.010	-	-		D160662at33208
OrthoFinder	1	1.000	-	-		FOG0005044
OrthoInspector	1	1.000	-	-		oto114601
orthoMCL	1	0.900	-	-		OOG6_116372
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R8848
SonicParanoid	1	1.000	-	-		X2572
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	18	18.200