DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment ZNF254 and CG4360

DIOPT Version :9

Sequence 1:	NP_975011.3	Gene:	ZNF254 / 9534	HGNCID:	13047	Length:	659	Species:	Homo sapiens
Sequence 2:	NP_650879.1	Gene:	CG4360 / 42413	FlyBaseID:	FBgn0038787	Length:	556	Species:	Drosophila melanogaster

Alignment Length:	442	Identity:	136/442 - (30%)
Similarity:	182/442 - (41%)	Gaps:	122/442 - (27%)

- Green bases have known domain annotations that are detailed below.

Human   286 IIHTGEKPYKCEECGKAFIWSSTLTEHKKIHTRKKPYKCEECGKAFIWSSTLTRHKRMHTGEKPY 350
            ::....|..:|..|...|...:||..|.||||.::||||:.|.|||...||||.|.::||||||:
  Fly   134 VVDDPRKKKQCHVCKNKFRQLTTLRNHMKIHTDERPYKCKHCDKAFRQISTLTNHVKIHTGEKPF 198

Human   351 KCEECGKAFSQSSTLTTHKIIH-----------------TGEKRYKCLECGKAFKQLSTLTTHKI 398
            .|..|.|.|.|.|||..|...|                 ||..:::..:..:|::|     .|:.
  Fly   199 TCNICAKDFRQQSTLINHIKTHKAAESSTPTSLLNYQPQTGSGKHRKSQMHQAYQQ-----QHQR 258

Human   399 IHVGEKLYKCEECGKGFNRSSNLTTHKIIHTGEKPYKCEECGKAFIWSSTLTKHKRIHTREKPYK 463
            :.:.:.||.        ...|:....:::    ||::|..|.:.|...|||..|:|.|...||||
  Fly   259 VQISKTLYS--------GSYSSPAAEELV----KPFQCSVCKRRFPQLSTLHNHERTHIDPKPYK 311

Human   464 CEECGKAFIWSSTLTRHKRMHTGEKPYKCEECGKSFSQSSTLTTHKIIHT--------------- 513
            ||.|.|:|...:||..||::|||:|||.|..|...|.|.||||.|...||
  Fly   312 CETCDKSFSQLATLANHKKIHTGDKPYTCSYCHMQFRQQSTLTNHLKTHTHQIAPGGVGGAGGGG 376

Human   514 ------------------------GEKPYKCEECGKAFNWSSTLTKHKIIH-------------- 540
                                    |..|....  |...| ...|..|.::|
  Fly   377 GAVTATVDHSMPAPLAPGTQQLTSGLLPNNLH--GSTAN-IIQLDHHPLLHFLDGSTTVSSVVAT 438

Human   541 --------------------------------TEEKPYKCEKCGKAFKQSSILTNHKRIHTGEKP 573
                                            ..::|:.|..|.:.|.|.|.|.||.:.||||||
  Fly   439 AAANTKVEHFQAGGSPSGRMTVVGTINMLKGDNPDRPFGCSVCQRFFSQQSTLVNHIKTHTGEKP 503

Human   574 YKCEECGKSFNRSSTFTKHKVIHTGVKPYKCEECGKAFFWSSTLTKHKRIHT 625
            |||:.|..:|.:.:|...|..||||.|||.|..|.|.|...|||..|.|:||
  Fly   504 YKCKICEVNFRQVATLNNHMKIHTGEKPYNCSFCPKQFRQKSTLQNHLRVHT 555

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ZNF254	NP_975011.3	KRAB	13..73	CDD:214630
		C2H2 Zn finger	184..204	CDD:275368
		C2H2 Zn finger	212..260	CDD:275368
		COG5048	264..625	CDD:227381	134/440 (30%)
		C2H2 Zn finger	268..288	CDD:275368	0/1 (0%)
		C2H2 Zn finger	296..316	CDD:275368	7/19 (37%)
		C2H2 Zn finger	324..344	CDD:275368	10/19 (53%)
		C2H2 Zn finger	352..372	CDD:275368	9/19 (47%)
		C2H2 Zn finger	380..400	CDD:275368	3/19 (16%)
		C2H2 Zn finger	408..428	CDD:275368	1/19 (5%)
		C2H2 Zn finger	436..456	CDD:275368	8/19 (42%)
		C2H2 Zn finger	464..484	CDD:275368	9/19 (47%)
		C2H2 Zn finger	492..512	CDD:275368	9/19 (47%)
		C2H2 Zn finger	520..540	CDD:275368	4/19 (21%)
		C2H2 Zn finger	548..568	CDD:275368	8/19 (42%)
		C2H2 Zn finger	576..596	CDD:275368	5/19 (26%)
		C2H2 Zn finger	604..624	CDD:275368	9/19 (47%)
		C2H2 Zn finger	632..652	CDD:275368
CG4360	NP_650879.1	C2H2 Zn finger	144..164	CDD:275368	7/19 (37%)
		zf-H2C2_2	157..181	CDD:290200	14/23 (61%)
		C2H2 Zn finger	172..192	CDD:275368	10/19 (53%)
		zf-H2C2_2	185..209	CDD:290200	13/23 (57%)
		C2H2 Zn finger	200..220	CDD:275368	9/19 (47%)
		C2H2 Zn finger	284..304	CDD:275368	8/19 (42%)
		zf-C2H2_8	287..363	CDD:292531	38/75 (51%)
		C2H2 Zn finger	312..332	CDD:275368	9/19 (47%)
		C2H2 Zn finger	340..360	CDD:275368	9/19 (47%)
		C2H2 Zn finger	478..498	CDD:275368	8/19 (42%)
		zf-H2C2_2	491..515	CDD:290200	14/23 (61%)
		C2H2 Zn finger	506..526	CDD:275368	5/19 (26%)
		zf-H2C2_2	519..543	CDD:290200	12/23 (52%)
		C2H2 Zn finger	534..554	CDD:275368	9/19 (47%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24377
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	1.100