DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment ZNF254 and trem

DIOPT Version :9

Sequence 1:	NP_975011.3	Gene:	ZNF254 / 9534	HGNCID:	13047	Length:	659	Species:	Homo sapiens
Sequence 2:	NP_650861.1	Gene:	trem / 42392	FlyBaseID:	FBgn0038767	Length:	439	Species:	Drosophila melanogaster

Alignment Length:	440	Identity:	124/440 - (28%)
Similarity:	183/440 - (41%)	Gaps:	88/440 - (20%)

- Green bases have known domain annotations that are detailed below.

Human   137 EGYNGLNQCFT-TAQSKVFQCDKYLKVFYKF---LNSNRPKIRHTEKKSFKCKK------RVKLF 191
            ||...|:..|: ||.:::   |:.|.:....   |:.|.|     :|...||.:      :.:|.
  Fly    21 EGEELLHDIFSETASTRL---DQMLHICAGIPVSLDDNFP-----DKMCSKCVRCLRLCYKFRLT 77

Human   192 CMLSHKTQH-KSIYHREKSYKCKECG-----------------KTF-NWSSTLTNHRKIYTEEK- 236
            |..||  || ..:..||.| .....|                 |:: :::|.|....|:..||.
  Fly    78 CQRSH--QHIMDMLDREAS-NANAAGEGDLLSIAEDLSVESVLKSWEDYASQLDGGMKVEGEEDQ 139

Human   237 -----PYKCEEYNKSPKQL-----STLTTHEIIHAGEKLYKCEECGEAFNRSSNLTTHKIIHTG- 290
                 .|..|:.:.....:     .|......|...|...:.||.....|.:|.....:...||
  Fly   140 QHQVITYVVEDGDTDDTNMFDVHDPTQPVPNEIEEAETYAEYEEYELLTNENSPEIAQEKGSTGT 204

Human   291 ----EKPYKCEECGKAFIWSSTLTEHKKIHTRKKPYKCEECGK---AFIWSSTLTRHKRMHTGEK 348
                |:|.: ||..:..:.|.  .::...|.  ||.||:..|:   |:..:|......:...|.|
  Fly   205 DVATEEPPE-EEIAEDILDSD--EDYDPTHA--KPEKCDRSGRKPVAYHKNSPKVETFKKKVGRK 264

Human   349 PYKCEECGKAFSQSSTLTTHKIIHTGEKRYKCLECGKAFKQLSTLTTHKIIHVGEKLYKCEECGK 413
            |            .:.|:|          |.|..||..:...:.||.|...|.|.|.::||.||:
  Fly   265 P------------RNKLST----------YICDVCGNIYPTQARLTEHMKFHSGVKPHECEICGR 307

Human   414 GFNRSSNLTTHKIIHTGEKPYKCEECGKAFIWSSTLTKHKRIHTREKPYKCEECGKAFIWSSTLT 478
            ||.::..|..|...|||.:||||..|..||...||.|||.||||:|:||.|:.|.:.|.:|..|.
  Fly   308 GFVQNQQLVRHMNTHTGNRPYKCNYCPAAFADRSTKTKHHRIHTKERPYVCDVCSRTFTYSDNLK 372

Human   479 RHKRMHTGEKPYKCEECGKSFSQSSTLTTHKIIHTGEKPYK--CEECGKA 526
            .||.:||||||:.|:.|||.|.::..|..|:..|.....::  .||..||
  Fly   373 FHKMIHTGEKPHVCDLCGKGFVKAYKLRLHRETHNRRITWRNDAEESTKA 422

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ZNF254	NP_975011.3	KRAB	13..73	CDD:214630
		C2H2 Zn finger	184..204	CDD:275368	7/26 (27%)
		C2H2 Zn finger	212..260	CDD:275368	10/76 (13%)
		COG5048	264..625	CDD:227381	89/273 (33%)
		C2H2 Zn finger	268..288	CDD:275368	4/19 (21%)
		C2H2 Zn finger	296..316	CDD:275368	3/19 (16%)
		C2H2 Zn finger	324..344	CDD:275368	4/22 (18%)
		C2H2 Zn finger	352..372	CDD:275368	2/19 (11%)
		C2H2 Zn finger	380..400	CDD:275368	6/19 (32%)
		C2H2 Zn finger	408..428	CDD:275368	8/19 (42%)
		C2H2 Zn finger	436..456	CDD:275368	10/19 (53%)
		C2H2 Zn finger	464..484	CDD:275368	7/19 (37%)
		C2H2 Zn finger	492..512	CDD:275368	7/19 (37%)
		C2H2 Zn finger	520..540	CDD:275368	4/7 (57%)
		C2H2 Zn finger	548..568	CDD:275368
		C2H2 Zn finger	576..596	CDD:275368
		C2H2 Zn finger	604..624	CDD:275368
		C2H2 Zn finger	632..652	CDD:275368
trem	NP_650861.1	zf-AD	11..87	CDD:214871	20/75 (27%)
		COG5048	<264..411	CDD:227381	65/168 (39%)
		C2H2 Zn finger	274..294	CDD:275368	6/19 (32%)
		zf-H2C2_2	287..311	CDD:290200	12/23 (52%)
		C2H2 Zn finger	302..322	CDD:275368	8/19 (42%)
		zf-H2C2_2	315..338	CDD:290200	11/22 (50%)
		C2H2 Zn finger	330..350	CDD:275368	10/19 (53%)
		zf-H2C2_2	345..367	CDD:290200	12/21 (57%)
		C2H2 Zn finger	358..378	CDD:275368	7/19 (37%)
		zf-H2C2_2	370..394	CDD:290200	13/23 (57%)
		C2H2 Zn finger	386..406	CDD:275368	7/19 (37%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	0	0.000