DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment NPEPPS and CG8773

DIOPT Version :9

Sequence 1:	XP_016880861.1	Gene:	NPEPPS / 9520	HGNCID:	7900	Length:	924	Species:	Homo sapiens
Sequence 2:	NP_650273.2	Gene:	CG8773 / 41634	FlyBaseID:	FBgn0038135	Length:	994	Species:	Drosophila melanogaster

Alignment Length:	899	Identity:	292/899 - (32%)
Similarity:	464/899 - (51%)	Gaps:	73/899 - (8%)

- Green bases have known domain annotations that are detailed below.

Human    41 GLAAMPEKRPFERLPADVSPINYSLCLKPDLLDFTFEGKLEAAAQVRQATNQIVMNCADIDIITA 105
            |..|.|||..: |||..:.|.:|.|.|.|::....|.|:......|.:||:|||::..:::|.:.
  Fly   111 GTTASPEKIDY-RLPGTLKPTHYDLYLFPNIETGEFSGQETITITVEEATDQIVLHSLNLNISSV 174

Human   106 SYAPEGDE--EIHATGFNYQNEDEKVTLSFPSTLQTGTGTLKIDFVGELNDKMKGFYRSKYTTPS 168
            |....|.:  ||..|..:...|.....|:.|.| :..|..|.|.|.|.:.:|:.|.|.|.|....
  Fly   175 SIMNTGSDTLEILETTVDAVREFLIFQLNEPLT-KGRTVRLHIGFEGSMANKIVGLYSSSYVKED 238

Human   169 GEVRYAAVTQFEATDARRAFPCWDEPAIKATFDISLVVP--KDRVALSNMNVIDRKPYPDDENL- 230
            ...::.|.::||.|.||:||||:||||:||.|.|:||.|  :|..|||||||        |.::
  Fly   239 ETRKWIATSKFEPTYARQAFPCFDEPALKAEFTITLVHPSGEDYHALSNMNV--------DSSVS 295

Human   231 ----VEVKFARTPVMSTYLVAFVVGEYDF----VETRS-KDGVCVRVYTPVGKAEQGKFALEVAA 286
                .||.||::..|||||..|:|.::.:    ::|:. .:...:.||....:.::...|:.:..
  Fly   296 QGAFQEVTFAKSVPMSTYLACFIVSDFAYKQVSIDTKGIGETFSMSVYATPEQLDKVDLAVTIGK 360

Human   287 KTLPFYKDYFNVPYPLPKIDLIAIADFAAGAMENWGLVTYRETALLIDPKNSCSSSRQWVALVVG 351
            ..:.:|.|||.:.|||||:|:.||.||.:||||:|||||||||:||.|...|.::::|.:|.|:.
  Fly   361 GVIEYYIDYFQIAYPLPKLDMAAIPDFVSGAMEHWGLVTYRETSLLYDEATSSATNKQRIASVIA 425

Human   352 HELAHQWFGNLVTMEWWTHLWLNEGFASWIEYLCVDHCFPEYDIWTQFVSADYTRAQELDALDNS 416
            ||.||.||||||||.||..|||||||||::|||.||..:||:.:..||..:.......||....|
  Fly   426 HEFAHMWFGNLVTMNWWNDLWLNEGFASFVEYLGVDAVYPEWKMRDQFTVSTLHSVLTLDGTLGS 490

Human   417 HPIEVSVGHPSEVDEIFDAISYSKGASVIRMLHDYIGDKDFKKGMNMYLTKFQQKNAATEDLWES 481
            |||..:|.:|.::.||||.|:||||:|::|||.|::|:..|::.:..||.:::...|.|.:.:..
  Fly   491 HPIIQTVENPDQITEIFDTITYSKGSSLVRMLEDFLGETTFRQAVTNYLNEYKYSTAETGNFFTE 555

Human   482 LENAS-GKPIAAVMNTWTKQMGFPLIYVEAEQVEDDRLLRLSQKKFCAG-GSYVGEDCP-----Q 539
            ::... |..:..:|.|||.|||.|::.:  |:|.|.. .:|:||:|.:. ..|..:..|     :
  Fly   556 IDKLELGYNVTEIMLTWTVQMGLPVVTI--EKVSDTE-YKLTQKRFLSNPNDYDADHEPSEFNYR 617

Human   540 WMVPITISTSEDPNQAKLKILMDKPEMNVVLKNVKPDQWVKLNLGTVGFYRTQYSSAMLESLLPG 604
            |.:|||..||.|....:|....|:.|:.|.:....  :|:|.|...||:||..|.:.:...|...
  Fly   618 WSIPITYFTSSDSVVQRLWFYHDQSEITVTVPAAV--EWIKFNADQVGYYRVNYDTDLWNDLADQ 680

Human   605 --IRDLSLPPVDRLGLQNDLFSLARAGIISTVEVLKVMEAFVNEPNYTVWSDLSCNLGILSTLLS 667
              ::..:...|||..|.||.|:||.:..:......::......|.:|..||..:..|..|...|.
  Fly   681 LVVQPSAFGSVDRAHLLNDAFALADSTQLPYATAFELTRYLDKETDYVPWSVAASRLTSLKRTLY 745

Human   668 HTDFYEEIQEFVKDVFSPIGERLGWDPKPGEGHLDALLRGLVLGKLGKAGHKATLEEARRRFKDH 732
            :|..|.:.:::...:..||...|.|  ..||.|||..||...|......|.::.|.||..:|...
  Fly   746 YTSTYAKYKKYATALIEPIYTALTW--TVGEDHLDNRLRVTALSAACSLGLESCLTEAGEQFNAW 808

Human   733 V-EGKQILSADLRSPVYLTVLKH-GDGTTLDIMLKLHKQADMQEEKNRIERVLGATLLPDLIQKV 795
            : :.:....||:|..||...::. |.....|.:.:|........||:::...|.|..:|.::|:.
  Fly   809 LAKPEDRPKADVRETVYYYGIQSVGSQEDWDAVWELFVNESDASEKSKLMYGLSAIQIPWILQRY 873

Human   796 LTFALSEE-VRPQDTVSVIGGVAGGSKHGRKAAWKFIKDNWEELYNRYQGGFLISRLIKVQWLTP 859
            :..|.:|| ||.||..:.:..:: .:..|....|.::::||:.|.:|:.        :..::|..
  Fly   874 IDLAWNEEYVRGQDYFTCLTYIS-ANPVGESLVWDYVRENWQRLVDRFG--------LNERYLGN 929

Human   860 VIPAL------------WDAEVGRSPEVGSSRLSWPTCYQLRDLQLIK----WL 897
            :||::            .:....:.||.|:.     |..::|.|:.:|    ||
  Fly   930 LIPSITARFSTQTKLEEMEQFFAKYPEAGAG-----TAARVRALETVKNNIVWL 978

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
NPEPPS	XP_016880861.1	None
CG8773	NP_650273.2	Peptidase_M1	122..515	CDD:279741	162/401 (40%)
		M1_APN_2	130..579	CDD:189008	179/457 (39%)
		ERAP1_C	655..969	CDD:288671	78/329 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0308
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D110058at2759
OrthoFinder	1	1.000	-	-		FOG0000044
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X67
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	5	4.820