Protein Alignment SPTLC2 and LCB2

DIOPT Version :10

• Sequence 1: NP_004854.1
• Gene: SPTLC2 / 9517
• HGNCID: 11278
• Length: 562
• Species: Homo sapiens
• Sequence 2: NP_010347.1
• Gene: LCB2 / 851634
• SGDID: S000002469
• Length: 561
• Species: Saccharomyces cerevisiae
• Alignment Length: 497
• Identity: 238/497 - (47%)
• Similarity: 335/497 - (67%)
• Gaps: 7/497 - (1%)

Human    43 GQIHHVTQNGGLYKRPFNEAFEET-PMLVAVLTYVGYGVLTLFGYLRDFLRYWRIEKCHHATERE 106
            |.::.|....|   :|..|...:| |..:::|||:.|.:|.:.|::.|||. ...:|..| .:..
Yeast    35 GHLYQVKSRHG---KPLPEPVVDTPPYYISLLTYLNYLILIILGHVHDFLG-MTFQKNKH-LDLL 94

Human   107 EQKDFVSLYQDFENFYTRNLYMRIRDNWNRPICSVPGARVDIMERQSHDYNWSFKYTGNIIKGVI 171
            |.......:.:||:||.|.:.|||.|.::||...|||..:..::|.||:.|..|.|:|.:.. .:
Yeast    95 EHDGLAPWFSNFESFYVRRIKMRIDDCFSRPTTGVPGRFIRCIDRISHNINEYFTYSGAVYP-CM 158

Human   172 NMGSYNYLGFARNTGSCQEAAAKVLEEYGAGVCSTRQEIGNLDKHEELEELVARFLGVEAAMAYG 236
            |:.||||||||::.|.|.:||.:.:::|.......|.:||..|.|.:.|:|||||:|.|.|:.:.
Yeast   159 NLSSYNYLGFAQSKGQCTDAALESVDKYSIQSGGPRAQIGTTDLHIKAEKLVARFIGKEDALVFS 223

Human   237 MGFATNSMNIPALVGKGCLILSDELNHASLVLGARLSGATIRIFKHNNMQSLEKLLKDAIVYGQP 301
            ||:.||:....|.:.|.||::||||||.|:..|.|||||.:|.|||.:|..||||:::.||.|||
Yeast   224 MGYGTNANLFNAFLDKKCLVISDELNHTSIRTGVRLSGAAVRTFKHGDMVGLEKLIREQIVLGQP 288

Human   302 RTRRPWKKILILVEGIYSMEGSIVRLPEVIALKKKYKAYLYLDEAHSIGALGPTGRGVVEYFGLD 366
            :|.||||||||..||::||||::..||:::.||||||.||::||||||||:|||||||.|.||:|
Yeast   289 KTNRPWKKILICAEGLFSMEGTLCNLPKLVELKKKYKCYLFIDEAHSIGAMGPTGRGVCEIFGVD 353

Human   367 PEDVDVMMGTFTKSFGASGGYIGGKKELIDYLRTHSHSAVYATSLSPPVVEQIITSMKCIMGQDG 431
            |:|||::||||||||||:||||...:.:||.||....:..|:.|:..||:.|.|:|::.|.|:..
Yeast   354 PKDVDILMGTFTKSFGAAGGYIAADQWIIDRLRLDLTTVSYSESMPAPVLAQTISSLQTISGEIC 418

Human   432 TSLGKECVQQLAENTRYFRRRLKEMGFIIYGNEDSPVVPLMLYMPAKIGAFGREMLKRNIGVVVV 496
            ...|.|.:|::|.|:||.|..|:.:|||:||..||||:||:||.|:|:.||.|.||:|.|.||||
Yeast   419 PGQGTERLQRIAFNSRYLRLALQRLGFIVYGVADSPVIPLLLYCPSKMPAFSRMMLQRRIAVVVV 483

Human   497 GFPATPIIESRARFCLSAAHTKEILDTALKEIDEVGDLLQLK 538
            .:||||:||||.|||:||:.|||.:|..|:.:.||||.|.||
Yeast   484 AYPATPLIESRVRFCMSASLTKEDIDYLLRHVSEVGDKLNLK 525

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SPTLC2	NP_004854.1	AAT_I	67..542	CDD:450240	232/472 (49%)
LCB2	NP_010347.1	AAT_I	57..525	CDD:450240	230/470 (49%)