DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment STXBP5L and l(2)gl

DIOPT Version :9

Sequence 1:	NP_001335272.1	Gene:	STXBP5L / 9515	HGNCID:	30757	Length:	1186	Species:	Homo sapiens
Sequence 2:	NP_001245801.1	Gene:	l(2)gl / 33156	FlyBaseID:	FBgn0002121	Length:	1161	Species:	Drosophila melanogaster

Alignment Length:	1284	Identity:	301/1284 - (23%)
Similarity:	488/1284 - (38%)	Gaps:	380/1284 - (29%)

- Green bases have known domain annotations that are detailed below.

Human    47 REEIQETLTSEYFQICKTVRHGFPHQPTALAFDPVQKILAIGTRTGAIRILGRPGVDCYCQH--- 108
            |..:|:.|    |...||.:|||||:|:|||:|||.|::||||:|||:::.|:|||:.|.||
  Fly    16 RHRLQKDL----FAYRKTAQHGFPHKPSALAYDPVLKLMAIGTQTGALKVFGQPGVELYGQHTLL 76

Human   109 ESGAAVLQLQFL---INEGALVSASSDDTLHLWNLRQKRPAILHSLKFNRERITYCHLPFQSK-- 168
            .:.|:.|.:|.|   ...|.::|.::.:.|.||   :...|.|..:|         .|||..|
  Fly    77 NNSASELNVQLLEWVYGTGRILSLTAANQLILW---EPVGATLLPIK---------TLPFDGKLK 129

Human   169 ------------WLYVGTERGNTHIVNIESFILSGYVIMWNKAIEL---STKTHPGPVVHLSDSP 218
                        .|::|||.||.:.:::.:|.:...||..:..:|.   :.|.:||.:..:...|
  Fly   130 KVSSLCCSLSKDLLWIGTEGGNIYQLDLHTFTIKEPVIYHDVVLEQVPPAYKLNPGAIESIRQLP 194

Human   219 RDEGKLLIGYENGTVVFWDLKS---KRAELRVYYDEAIHSIDWHHEGKQFMCSHSDGSLTLWNLK 280
            ....|||:.|..|..|.||.:|   :||.:...:.::: .:..:.||.:|...|:|||...|::.
  Fly   195 NSPSKLLVAYNRGLCVLWDFESASVQRAYIAPGHGQSV-GLTVNFEGSEFTWYHADGSYATWSID 258

Human   281 SPSRPFQTT-IPHGKSQREGRKSESCKPILKVEYKTCKNSEPFIIFSGGL---SY-DKACRRPSL 340
            :|..|.... :|:|        .:.||.|.:: ||..:.|...|:||||:   :| |..|  .|:
  Fly   259 NPEPPSNVNYVPYG--------PDPCKSINRL-YKGKRRSNDVIVFSGGMPRSAYGDHNC--VSV 312

Human   341 TIMHGKAITVLEMDHPIVEFLTLCETPYPNEFQEPYAVVVLLEKDLIVVDLTQSNFPIFENPYPM 405
            ....|..: .|:....:::|....|    |.......:|||||::|...|||..|....:.||..
  Fly   313 HASDGHKV-CLDFTSKVIDFFVTFE----NNRDVAEVLVVLLEEELCAYDLTDPNICAIKAPYLH 372

Human   406 DIHESPVTCTAYFADCPPDLILVLYSIGVK---HKKQGYSNKEWPISGGAW--NL------GAQT 459
            .:|.|.|||. |.|.   :::..:|...::   .:...|||..|||:||..  ||      .|..
  Fly   373 SVHASAVTCN-YLAS---EVVQSVYESILRAGDEQDIDYSNISWPITGGTLPDNLEESVEEDATK 433

Human   460 YPEIIITGHADGSIKFWDASAITLQMLYKLKTSKVF--------------EKQKVGEGKQ----- 505
            ..||::|||.|||:||||.:.:.|:.:|..|||.:|              ..::|.||:.
  Fly   434 LYEILLTGHEDGSVKFWDCTGVLLKPIYNFKTSSIFGSESDFRDDAAADMSAEQVDEGEPPFRKS 498

Human   506 -TCEIVEEDP-FAIQMIYWCPESRIFCVSGVSAYVIIYKFSRHEITTEIVSL--EVRLQYDVEDI 566
             ..:...:|| .|::.|.:||::....|.|.:..::|..|         :.|  :|.|:|
  Fly   499 GLFDPYSDDPRLAVKKIAFCPKTGQLIVGGTAGQIVIADF---------IDLPEKVSLKY----- 549

Human   567 ITPEPETSPPFPDLSAQLPSSRSLSGSTNTVASEGVTKDSIPCLNVKTRPV---RMPP---GYQA 625
                         :|..|.|.|           :|........|||::..:   .:|.   |...
  Fly   550 -------------ISMNLVSDR-----------DGFVWKGHDQLNVRSNLLDGEAIPTTERGVNI 590

Human   626 ELVIQLVWVDGEPPQQITSLAVSSAYGIVAFGNCNGLAVVDFIQKTVLLSMGTIDLYRSSDLYQR 690
            ..|:|::     ||..||.:|:.:::|:|:.|..:||.:.||
  Fly   591 SGVLQVL-----PPASITCMALEASWGLVSGGTAHGLVLFDF----------------------- 627

Human   691 QPRSPRKNKQFIADNFCMRGLSNFYPDLTKRIRTSYQSLTELNDSPVPLELERCKSPTSDHVNGH 755
                                 .||.|                                   |...
  Fly   628 ---------------------KNFVP-----------------------------------VFHR 636

Human   756 CTSPTSQSCSSGKRLSSADVSKVNRWGPGRPPFRKAQSAACMEISLPVTTEENRENSYNRS---- 816
            ||...:....:|::||.            |..|:|:...:..::....:|..|:.|....:
  Fly   637 CTLNPNDLTGAGEQLSR------------RKSFKKSLRESFRKLRKGRSTRTNQSNQVPTTLEAR 689

Human   817 ---RSSSISSIDKDSKEAITALYFMDSFARKNDSTISPCLFVGTSLGMVLIISLNLPLADEQRFT 878
               |.......|......:..|.|..::. .|.:..||.|:..|:...|.:..|:||.|.
  Fly   690 PVERQIEARCADDGLGSMVRCLLFAKTYV-TNVNITSPTLWSATNASTVSVFLLHLPPAQ----- 748

Human   879 EPVMVLPSGT-------------------FLSLKGAVLTFSCMDRMGGLMQPPYEVWRDPNNIDE 924
            .....:||.:                   .|..:..|:..|..|:.|..:        |..|..|
  Fly   749 TAATAVPSASGNAPPHMPRRISAQLAKEIQLKHRAPVVGISIFDQAGSPV--------DQLNAGE 805

Human   925 NEKSWRRKVVMNSSSASQEIGDHQYTIICSEKQAKVFSLPS------------------------ 965
            |.....|                  .:|.||:|.||||||.
  Fly   806 NGSPPHR------------------VLIASEEQFKVFSLPQLKPINKYKLTANEGARIRRIHFGS 852

Human   966 -------QTCLYVH------------------NITETSFILQANVVVMCSSACLACFCANGHIMI 1005
                   :|...:|                  ||:.:..:.:.:|.   :...|.|....|.||:
  Fly   853 FSCRISPETLQSMHGCSPTKSTRSHGDGEADPNISGSLAVSRGDVY---NETALICLTNMGDIMV 914

Human  1006 MSLPSLRPMLDVNYLPLTDMRIARTFCFTNEGQALYLVSPTEIQRLTYSQ------------EMC 1058
            :|:|.|:..|:...:...|:....:.||||.|:|||::|.:|:||:..:.            |..
  Fly   915 LSVPELKRQLNAAAVRREDINGVSSLCFTNSGEALYMMSSSELQRIALATSRVVQPTGVVPVEPL 979

Human  1059 DNLQDML--GDLFTPIET---PEAQNRGFLKGLFGGSGQTFDREELFGEASAGKASRSLAQHIPG 1118
            :|.:.:|  .|.....||   .|..|...:|...|.|..|...||..|..|..:.:.....:.|.
  Fly   980 ENEESVLEENDAENNKETYACDEVVNTYEIKNPSGISICTRPAEENVGRNSVQQVNGVNISNSPN 1044

Human  1119 PGSIEGMKGAAGGV----------MGELTRARIALDERGQRLGELEEKT 1157
            ..: |.:..:.|.:          |...|...|..:|...||..|..:|
  Fly  1045 QAN-ETISSSIGDITVDSVRDHLNMTTTTLCSINTEETIGRLSVLSTQT 1092

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
STXBP5L	NP_001335272.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	15..40
		WD40	74..>281	CDD:421866	70/232 (30%)
		WD 1	74..107		19/32 (59%)
		WD40 repeat	74..107	CDD:293791	19/32 (59%)
		WD 2	114..153		10/41 (24%)
		WD40 repeat	115..153	CDD:293791	10/40 (25%)
		WD 3	158..194		11/49 (22%)
		WD40 repeat	211..248	CDD:293791	12/39 (31%)
		WD 4	213..247		12/36 (33%)
		WD40	249..>552	CDD:225201	94/339 (28%)
		WD 5	253..285		9/31 (29%)
		WD40 repeat	253..279	CDD:293791	8/25 (32%)
		LLGL	288..396	CDD:400597	31/112 (28%)
		WD 6	307..349		14/45 (31%)
		WD 7	357..391		9/33 (27%)
		WD 8	413..490		30/87 (34%)
		WD 9	518..629		21/118 (18%)
		WD 10	643..705		9/61 (15%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	748..771		4/22 (18%)
		WD 11	832..889		14/75 (19%)
		WD 12	898..969		19/101 (19%)
		WD 13	974..1018		11/43 (26%)
		WD 14	1032..1055		12/22 (55%)
		R-SNARE_STXBP5	1119..1179	CDD:277246	10/49 (20%)
l(2)gl	NP_001245801.1	WD40 repeat	39..78	CDD:293791	21/38 (55%)
		WD40 repeat	84..126	CDD:293791	13/53 (25%)
		WD40 repeat	131..174	CDD:293791	9/42 (21%)
		WD40 repeat	188..224	CDD:293791	12/35 (34%)
		LLGL	268..>338	CDD:285555	21/85 (25%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	52	1.000	Domainoid score	I11495
eggNOG	1	0.900	-	-		E1_KOG1983
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000702
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X453
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	5	4.810