Protein Alignment ADAMTS1 and AdamTS-A

DIOPT Version :10

• Sequence 1: NP_008919.3
• Gene: ADAMTS1 / 9510
• HGNCID: 217
• Length: 967
• Species: Homo sapiens
• Sequence 2: NP_996218.1
• Gene: AdamTS-A / 41887
• FlyBaseID: FBgn0286071
• Length: 1688
• Species: Drosophila melanogaster
• Alignment Length: 1006
• Identity: 324/1006 - (32%)
• Similarity: 471/1006 - (46%)
• Gaps: 192/1006 - (19%)

Human    78 LHAFDQQLDLELRPDSSFLAPGFTLQNVG-RKSGSETPLPETDL----AH--CFYSGTVNGDPSS 135
            |:.|.:||.|.||.|:||: ...::.::. .|.|.|.|.|||:.    .|  |||||.|..||.|
  Fly   298 LNVFGRQLHLVLRQDASFV-HNHSMTHIRILKEGEEHPGPETEAEAEQRHLGCFYSGYVEDDPHS 361

Human   136 AAALSLCEGVRGAFYLLGEAYFIQPL--PAASERLATAAPGEKPPAPLQFHLLRRNRQGDVGGTC 198
            ..::|||.|:.|.......|..|||:  .::.|.|...           |...:||.:..|....
  Fly   362 MVSVSLCGGMTGYIKTSFGALLIQPVNRTSSDEVLHRV-----------FRKSQRNARHAVSKFE 415

Human   199 GVVDDEPRPTGKAETEDEDEGTEGEDEGAQWSPQDPALQGVGQPTGTGSI-RKKRF---VSSHRY 259
            ..:||.   ..|.|...|:|                      |.:.:..: ||||.   |.:..|
  Fly   416 LGLDDF---MSKLEQVQEEE----------------------QKSKSRKLNRKKRHYADVDNQVY 455

Human   260 -VETMLVADQSMAEFHGSGLKHYLLTLFSVAARLYKHPSIRNSVSLVVVKILV---IHDEQKGPE 320
             :|.::..|.||.:|||..|:.|:|.|.|:.:.::...||.||:.:::|:::.   |:|:
  Fly   456 TLEVLIAVDNSMKQFHGEDLQPYILILMSIVSSIFADASIGNSIRILLVRLISLPNINDQ----- 515

Human   321 VTSNAALTLRNFCNWQKQHNPPSDRDAEHYDTAILFTRQDLCGS---QTCDTLGMADVGTVCDPS 382
             |.::...|::||.:..|       .....|||:|.||:.:|||   :.|..||:|::||||. |
  Fly   516 -THSSNEMLKHFCQFINQ-------SGYERDTAMLITREPICGSVPGKICHMLGLAELGTVCS-S 571

Human   383 RSCSVIEDDGLQAAFTTAHELGHVFNMPHDDAKQC---ASLNGVNQDSHMMASMLSNLDHSQPWS 444
            .|||:::|.||..|||.||||||:.||.|||..:|   .:....|:..|:|:|::....|...||
  Fly   572 SSCSIVQDTGLPTAFTMAHELGHILNMNHDDDDKCMPYVTRQNNNKVLHIMSSVMGIHMHPWSWS 636

Human   445 PCSAYMITSFLDNGHGECLMDK-----PQNPIQLPGDLPGTSYDANRQCQFTFGEDSKHCPDAAS 504
            .||.:.::.||:.....||...     |....:|||::    |..:.|||.:||.|..:|| ...
  Fly   637 KCSRHFVSEFLEKTDKSCLETSVGAHIPYGTERLPGEI----YSLDAQCQLSFGNDFGYCP-TDE 696

Human   505 TCSTLWCTGTSGGV-LVCQTKHFPWADGTSCG-EGKWCINGKCVNKTDRKH-FDTPFHGSWGMWG 566
            .|..|||..|||.. ..|.:.:.||||||.|| .|.||..||||:   .|| :....:|.||.|.
  Fly   697 ECKRLWCNRTSGNSNEQCASSNLPWADGTPCGSSGHWCQRGKCVS---NKHGYGRQVNGGWGPWT 758

Human   567 PWGDCSRTCGGGVQYTMRECDNPVPKNGGKYCEGKRVRYRSCNLEDCPDNNGKTFREEQCEAHNE 631
            |:..||.|||||||.:.|||:.|||:||||||.|.|.:|||||...||..:... ||:||.|.|.
  Fly   759 PFTPCSLTCGGGVQESRRECNQPVPENGGKYCTGSRKKYRSCNTHQCPPGSMDP-REQQCYAMNG 822

Human   632 FSKASFGSGPAVEWIPKYAGVSPKDRCKLICQAKGIGYFFVLQPKVVDGTPCSPDSTSVCVQGQC 696
            .:....|..|..:|:|||    .||.|||.|:......:|:|:..|.|||.|:.||...||.|.|
  Fly   823 RNMNIPGVNPDTKWVPKY----EKDACKLFCRMDMKVTYFMLKSMVTDGTSCAVDSFDKCVNGIC 883

Human   697 VKAGCDRIIDSKKKFDKCGVCGGNGSTCKKISGS-VTSAKPGYHD----------IITIPTGATN 750
            ..||||..::|..|.||||||.|...||.:::|: :.|...|.:|          :..||.||:|
  Fly   884 RPAGCDNELNSIAKLDKCGVCEGRNDTCHEVTGNLLVSNLLGLNDGNEPNKTLYYVTRIPKGASN 948

Human   751 IEVKQRNQRGSRNNGSFLAIKAADGTYILNGDYTLSTLEQDIMYKGVVLRYSGSSAALERIR-SF 814
            |.:.||..    .:.:|:.:.......:|||.: |.|.....:|.||.::|:|||:.:|::. ::
  Fly   949 IIITQRGY----PDQNFIVLTDDRDNELLNGKF-LKTYPLKFVYAGVTMQYTGSSSVVEQVNTTY 1008

Human   815 S-PLKEPLTIQVLTVGNALRPK-------IKYTYFVKKKKESFNAIPTFSAWVIEEWGECSKSCE 871
            | .|...|.:|::::.  :.|.       :.|:|.:.|..: :.|......|.::....|...||
  Fly  1009 SWKLSRDLIVQIISLD--VSPSKRQDTVLLSYSYTIDKPPD-YEAEVEIYRWEMQAPSNCDSLCE 1070

Human   872 LGWQRRL-------------------------------VECR-DINGQPASECAKEVKPASTRPC 904
             |...||                               .:|| ::.....|||:.......||.
  Fly  1071 -GRSHRLPACISTTQGVKVAPQFCDKSAMPKIDDRACNTDCRLNLTVTSISECSAACGELGTRE- 1133

Human   905 ADHPCPQ--------------------------------WQLGEWSSCSKTCGKGYKKRSLKCLS 937
            ..:.|.|                                |.|.|||:|||:||.|.::|...|..
  Fly  1134 KTYACVQTFTNMQRSNIVDMSYCKLKFDVAYHEECREGCWVLSEWSTCSKSCGTGSQQREAHCYL 1198

Human   938 HDGGVLSHESCDPLKKP--KHFIDFCTMAEC 966
            |:..| |.:.|:|..||  ...|..|....|
  Fly  1199 HNSRV-SDDLCNPRTKPHLNTLIGICNTESC 1228

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ADAMTS1	NP_008919.3	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..27
		Pep_M12B_propep	59..166	CDD:460254	36/96 (38%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	192..250		8/58 (14%)
		Cysteine switch. /evidence=ECO:0000250	196..203		0/6 (0%)
		ZnMc_ADAMTS_like	258..463	CDD:239801	75/214 (35%)
		ADAMTS_CR_2	478..546	CDD:465496	30/69 (43%)
		TSP1	562..614	CDD:214559	32/51 (63%)
		ADAMTS_CR_3	<658..724	CDD:437068	30/65 (46%)
		Spacer	725..849		34/143 (24%)
		ADAMTS_spacer1	726..842	CDD:461796	33/135 (24%)
		TSP1_ADAMTS	858..909	CDD:465950	14/82 (17%)
		TSP1_ADAMTS	912..>954	CDD:465950	18/41 (44%)
AdamTS-A	NP_996218.1	Pep_M12B_propep	<295..394	CDD:460254	36/96 (38%)
		ZnMc_ADAMTS_like	455..655	CDD:239801	75/213 (35%)
		ADAMTS_CR_2	671..740	CDD:465496	32/73 (44%)
		TSP1	754..806	CDD:214559	32/51 (63%)
		ADAMTS_CR_3	815..911	CDD:437068	42/99 (42%)
		TSP1	1172..1229	CDD:214559	23/58 (40%)
		TSP1_ADAMTS	1243..1282	CDD:465950
		TSP1_ADAMTS	1355..1405	CDD:465950
		GON	1493..1687	CDD:462559