DRSC/TRiP Functional Genomics Resources

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Protein Alignment ADAMTS1 and sona

DIOPT Version :10

Sequence 1:NP_008919.3 Gene:ADAMTS1 / 9510 HGNCID:217 Length:967 Species:Homo sapiens
Sequence 2:NP_001137746.1 Gene:sona / 37762 FlyBaseID:FBgn0034903 Length:1102 Species:Drosophila melanogaster


Alignment Length:689 Identity:154/689 - (22%)
Similarity:247/689 - (35%) Gaps:203/689 - (29%)


- Green bases have known domain annotations that are detailed below.


Human    60 LVVPELERAPGHGTTRLRLHAFDQQLDLELRPDSSFL--AP-GFTLQNVGRKSGSETPLPETDLA 121
            |..||:.....|..:   ..||.|.|:|.||......  || ...:..||.:..:...|...::.
  Fly   108 LFAPEVSAIKSHNVS---FSAFGQHLNLSLRATQGLFKGAPHQLRMWTVGSEPNATHGLDLQEIV 169

Human   122 HCFYS----GTVNGDPSSAAAL----------SLCEGVRGAFYLLGEAYFIQPLP---------- 162
            |..::    |.|..|..:.||:          .:.||      .:|....|:|||          
  Fly   170 HEQHTSNDVGEVFQDEKNMAAILMRRHMETGDLIMEG------SIGHDLVIKPLPHELSPNPEES 228

Human   163 --AASERLATAAPGE-------KPPAPLQFHLL-------RRNRQGDVGGTCGVVDDEPRPTGKA 211
              ...:|.|:||.|:       :|...|....|       ||:|:           ..|......
  Fly   229 HHIIYKREASAAEGQLSDFAFMEPDDLLASEKLERLQRRQRRSRR-----------SAPSSPDFE 282

Human   212 ETEDEDEGT-EGEDEGAQWSPQDPALQGVGQPTGTGSIRKKRFVSSHRYVETMLVADQSMAEFHG 275
            :..|||||. :||.:.|:              :.|.|.|:..::.   |.|.:::.|......||
  Fly   283 DLNDEDEGALDGEPQVAE--------------SRTRSRRQAPYII---YPEVLVIVDYDGYRLHG 330

Human   276 SG---LKHYLLTLFS---VAARLYKHPSIRNSVSLVVVKILVIHDEQKGPEVT------------ 322
            ..   :|.|.::.::   :..||.|.|.||.|::.:::        .:|.:.|            
  Fly   331 GDNLQVKRYFISFWNGVDLRYRLLKGPRIRISIAGIII--------SRGRDATPYLERNRVGRDA 387

Human   323 --SNAALTLRNFCNWQKQHNPPSDRDAEHYDTAILFTRQDLC------GSQTCDTLGMADVGTVC 379
              |.||||......::::..|.       ||.|:..|:.|:|      |.....|.|.|.||..|
  Fly   388 IDSAAALTDMGKYLFRERRLPV-------YDIAVAITKLDMCRRTSAYGECNRGTAGFAYVGGAC 445

Human   380 ------DPSRSCSVIED-DGLQAAFTTAHELGHVFNMPHDDAKQCASLNGVN------QDSHMMA 431
                  :...|.::||| .|.......|||:||:....||.:...:.|.|..      :|.::| 
  Fly   446 VVNKRLEKVNSVAIIEDTGGFSGIIVAAHEVGHLLGAVHDGSPPPSYLGGPGAQRCRWEDGYIM- 509

Human   432 SMLSNLDHSQ---PWSPCSAYMITSFLDNGHGECLMDKPQNPIQLPGDLPGTSYDANRQCQFTFG 493
               |:|.|::   .||.|:......||:.....||.:.|.....|...||||....:.||:...|
  Fly   510 ---SDLRHTERGFRWSACTVQSFHHFLNGDTATCLHNAPHEDSALGRSLPGTLLSLDAQCRRDRG 571

Human   494 EDSKHCPDAASTCSTLWCTGTSGGVLVCQTKHFPWADGTSCGEGKWCINGKCV------------ 546
              :..|......|:.|:|.....|..|.   :.|.|:|::||.|..|::|:|.            
  Fly   572 --TYACFKDERVCAQLFCFDAQTGYCVA---YRPAAEGSACGNGYHCLDGRCTPLPSNIIPDYGH 631

Human   547 ------NKTDRKHFDTPFHGSWGMWGPWGDCSRTCGGGVQYTMRECDNPVPKNGGKYCEGKRVRY 605
                  ||.|.|                    :.....|:.:..|.::...:..           
  Fly   632 NYRLVYNKIDNK--------------------KDAAEDVESSSEETESQEDETE----------- 665

Human   606 RSCNLEDCPDNNGKTFREEQCEAHNEFSKASFGSGPAVE 644
               ::||  .:.|.|..|||  ..|:..::|...|.|.:
  Fly   666 ---SVED--QDEGTTSSEEQ--EDNKIEQSSAAGGAAAQ 697

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
ADAMTS1NP_008919.3 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..27
Pep_M12B_propep 59..166 CDD:460254 29/134 (22%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 192..250 11/58 (19%)
Cysteine switch. /evidence=ECO:0000250 196..203 0/6 (0%)
ZnMc_ADAMTS_like 258..463 CDD:239801 59/246 (24%)
ADAMTS_CR_2 478..546 CDD:465496 20/67 (30%)
TSP1 562..614 CDD:214559 4/51 (8%)
ADAMTS_CR_3 <658..724 CDD:437068
Spacer 725..849
ADAMTS_spacer1 726..842 CDD:461796
TSP1_ADAMTS 858..909 CDD:465950
TSP1_ADAMTS 912..>954 CDD:465950
sonaNP_001137746.1 ZnMc_salivary_gland_MPs 313..542 CDD:239800 60/250 (24%)
ADAMTS_CR_2 556..619 CDD:465496 20/67 (30%)
Blue background indicates that the domain is not in the aligned region.

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