Protein Alignment ADAMTS1 and stl

DIOPT Version :10

• Sequence 1: NP_008919.3
• Gene: ADAMTS1 / 9510
• HGNCID: 217
• Length: 967
• Species: Homo sapiens
• Sequence 2: NP_001097423.1
• Gene: stl / 37619
• FlyBaseID: FBgn0086408
• Length: 1136
• Species: Drosophila melanogaster
• Alignment Length: 1080
• Identity: 240/1080 - (22%)
• Similarity: 368/1080 - (34%)
• Gaps: 322/1080 - (29%)

Human    11 RRKLGSDMGNAERAPGSRSFGPVPTLLLLAAALLAVSDALGRPSEEDEELVVPELERAPGHGTTR 75
            ||.|.|:.||          ||:|                  |.||::|        |......|
  Fly   127 RRSLPSEDGN----------GPLP------------------PEEEEQE--------AGEDVEAR 155

Human    76 LRLHAFDQQLDLELRPDSSFLAPGFTLQNVGRKSGSETPLPETDLAHCFYSGTVNGDPSSAAALS 140
            |:|....|.:      |.:|:....| :| |.:....:|.....|..|||.       |.||||.
  Fly   156 LQLQQSPQLI------DDAFIFIRRT-EN-GTQFVEHSPQLLKRLERCFYR-------SPAAALD 205

Human   141 LCE--GVRGAFYLLGEAYFIQPLPAASERLATAAPGEKPPAPLQFHLLRRNRQGDVGGTCGVVDD 203
            |||  .|||.|...|....|.||||   |..|..           |:|.:.|....||  |..:.
  Fly   206 LCEPGNVRGVFQQNGSDLVIHPLPA---RFGTGT-----------HVLYQARVDKSGG--GYSEA 254

Human   204 EPRPTGKAETEDEDEGTEGEDEGAQWSPQDPALQGVGQ---------------PTGTGSIRKKRF 253
            ..|.|    ....|...:.|.:..:::.....|:...|               |......|::|:
  Fly   255 SSRRT----ASPLDSQLQFEPDAEEFNEPRRRLRAQSQLQSPLRLRFQPRHHHPHQHHQQRRRRY 315

Human   254 VS-----------SHRYVETMLVADQSM-AEFH-------GSGLKHYLLTLFSVAARLYKHPSIR 299
            :.           ...::||.:..|..: |...       .|.:..:||.:.:....||.||::.
  Fly   316 IGDAPRSRWSDIPEELFIETAIFVDSDLYAHMQKNFPTNTESKVVSFLLAMINGVQLLYHHPTLG 380

Human   300 NSVSLVVVKILVIHDEQKGPEVTSNAALT--LRNFCNWQKQHNPPSDRDAEHYDTAILFTRQDLC 362
            ..::. |:|.|.|......|.:..:..:.  |.:||.||::.||.||.|..|||.|::.|..||.
  Fly   381 RRINF-VLKRLEIWKSWDPPGLVRSRDVENYLNSFCKWQEKLNPFSDADPLHYDHALVLTGLDLV 444

Human   363 ----GSQTCDTLGMADVGTVCDPSRSCSVIEDDGLQAAFTTAHELGHVFNMPHDDAKQCASLNGV 423
                |......:|||.|..:|....||::.|....::.|..|||:||...|.| |||:.:    .
  Fly   445 TYDKGKANSQVVGMATVKGMCTSIYSCTINEAKHFESVFVVAHEIGHNLGMRH-DAKEIS----C 504

Human   424 NQDSHMMASMLSNLDHSQPWSPCSAYMITSFLDNGHGECLMDKPQ--NPIQ--LPGDLPGTSYDA 484
            :...|:|:..|.:  ....||.||...:..||.:...|||.|:..  .|..  ..|.|||..::|
  Fly   505 DPTMHIMSPKLGS--GKVTWSKCSRTYLEDFLMDPQAECLFDRDSFAGPWDHTAGGRLPGERFNA 567

Human   485 NRQCQFTFGEDSKHCPDAASTCSTL-WCTGTSGGVLVCQTKHFPWA-----DGTSCGEGKWCING 543
            |:||...||::...    |||.|.: .|..     |.|:....||.     :||.||...||..|
  Fly   568 NQQCMLRFGKNFMQ----ASTQSKMEICRD-----LHCRQDGLPWTSHPALEGTECGPNMWCRGG 623

Human   544 KCVNKTDR------------------------KH--------------FDTPFHGSWGMWGPWGD 570
            .|..::.:                        :|              .|....||...||.|.:
  Fly   624 TCEARSSKQGSYSALKSWPPEHIPEATHEKIIRHEPNRIPPLLHDYNPMDNELPGSPSNWGEWSE 688

Human   571 ---CSRTC-----------GGGVQYTMRECDNPVPKNGGKYCEGKRVRYRSCNLEDC---PDNNG 618
               |...|           ..|::...|.|.| .|..    |.|:..|:.:||...|   |....
  Fly   689 PSACESGCLYGQSRRLLEGSTGLRTLNRSCLN-FPSR----CIGRDRRFVTCNTPQCHKVPVQTI 748

Human   619 KTFREEQCEAHNEFSKASFGSGPAVEWIPKYAGVSPKDRCKLICQAKGIG-----YFFVLQPKVV 678
            ..|..:.|....:......|.|   :.:|.....|    ||:.|:.:..|     :.|      .
  Fly   749 NDFATQVCMQARKSDPELTGEG---QQLPSTLDAS----CKIFCRTRTNGTKSRRWTF------P 800

Human   679 DGTPC-----SPDSTSVCVQGQCVKAGCDRIIDSKKKFDKCGVCGGNGSTCKKISGSVT------ 732
            |||.|     :|:..:.|:.|:|.:..||....:..|.|        .|.|:..|...|
  Fly   801 DGTTCKAKQHNPEDITYCISGRCERFSCDNSTSNFFKMD--------SSFCEARSVRPTRDSSDQ 857

Human   733 ---------------SAKP---GYHDIITIPTGATNIEVKQRNQRGSRN---------------- 763
                           ..||   .|.:           ||.:|...|..|
  Fly   858 ESRQQTNRQRYAERQEGKPQKNHYEN-----------EVAKRPSYGQGNHINAPASPYKRRNYHK 911

Human   764 -------------NGSFLAI---KAADGTYILNGDYTLSTLEQDIMYKGVVLRYSGSSAALERIR 812
                         :.|.:|:   .:::..::.:.....:.:......:||..|.:|    :|.|:
  Fly   912 PYPPEIPRPPPPASASLIALDRSSSSESEWVAHPGCHSNCMTDSKGVQGVTSRLTG----VESIQ 972

Human   813 SFSPLKEPLTIQVLTVGNALRPKIKYT-YFVKKKKESFNAIPTFSAWVIEEWGECSKSCELGWQR 876
            ..|...:|.        ..|:...:|. ....:.::....:....|.:.....|..:||.:|.|.
  Fly   973 LCSYRIQPC--------ERLQTAAEYAEQTCARYRQKVRGLSGHGAQISASIDEPDRSCRVGCQD 1029

Human   877 RLVECRD--INGQ-----PASECAKEVKPASTRPCADHPC 909
            ..::.|.  :||:     |.:.|:    |...|.|....|
  Fly  1030 EFIKYRYYLVNGRNGHFPPGTRCS----PVGKRYCVYGRC 1065

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ADAMTS1	NP_008919.3	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..27		6/15 (40%)
		Pep_M12B_propep	59..166	CDD:460254	34/108 (31%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	192..250		10/72 (14%)
		Cysteine switch. /evidence=ECO:0000250	196..203		2/6 (33%)
		ZnMc_ADAMTS_like	258..463	CDD:239801	63/218 (29%)
		ADAMTS_CR_2	478..546	CDD:465496	24/73 (33%)
		TSP1	562..614	CDD:214559	16/68 (24%)
		ADAMTS_CR_3	<658..724	CDD:437068	18/75 (24%)
		Spacer	725..849		22/180 (12%)
		ADAMTS_spacer1	726..842	CDD:461796	22/172 (13%)
		TSP1_ADAMTS	858..909	CDD:465950	13/57 (23%)
		TSP1_ADAMTS	912..>954	CDD:465950
stl	NP_001097423.1	ZnMc_ADAMTS_like	331..543	CDD:239801	64/219 (29%)
		ADAMTS_CR_2	561..625	CDD:465496	24/72 (33%)
		TSP1	683..741	CDD:214559	15/62 (24%)