DRSC/TRiP Functional Genomics Resources

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Protein Alignment ADAMTS1 and loh

DIOPT Version :10

Sequence 1:NP_008919.3 Gene:ADAMTS1 / 9510 HGNCID:217 Length:967 Species:Homo sapiens
Sequence 2:NP_609406.2 Gene:loh / 34435 FlyBaseID:FBgn0032252 Length:880 Species:Drosophila melanogaster


Alignment Length:758 Identity:165/758 - (21%)
Similarity:258/758 - (34%) Gaps:240/758 - (31%)


- Green bases have known domain annotations that are detailed below.


Human   304 LVVVKIL----VIHDEQKGPEVTSNAALT----LRNFCNWQKQHNPPSDRDA----EHYDTAILF 356
            |::..||    .|||..     ...|.||    ::...:|.::|..|..:..    .:|:.|.|:
  Fly     5 LLIFSILTILATIHDSS-----FVQADLTTKERIKKHQDWLREHRKPKTKKKISINSYYELANLW 64

Human   357 -TRQDLCGSQTCDTLGMADVGTVCDPSRSCSVIEDDGLQAAFTTAHELGHVFNMPHDDAKQCASL 420
             ||:||...:.             .|:.....:|::       |..::.:..:.....:....||
  Fly    65 HTRKDLSSPKQ-------------KPNNKEEYLENE-------TTSKISNKSDEKVLKSSTIISL 109

Human   421 NGVNQDSHMMASMLSNLDHSQPWSPCSAYMITSFLDNGHGECLMDKPQ--------NPIQLPGDL 477
            |..|..:....|:|..       :...:.......::|:.......|:        ||.|     
  Fly   110 NATNPSTSTFKSVLET-------TTLPSVTTKDLFESGNVATTRQTPKVEEVFSSPNPPQ----- 162

Human   478 PGTSYDANRQCQFTFGEDSKHCPDAASTCSTLWCTGTSGGVLVCQTKHFPWADGTSCGEGKWCIN 542
                                   :|.|:.|                                   
  Fly   163 -----------------------EATSSTS----------------------------------- 169

Human   543 GKCVNKTDRKHFDTPFHGSWGMWGPWGDCSRTCGGGVQYTMREC-------DNPVPKNGGKYCEG 600
                .|..:|.:..|   .|..|..|..|||:|||||:|.:|:|       :|.:..|.   |.|
  Fly   170 ----KKAKKKVYPYP---RWDKWSDWSSCSRSCGGGVKYQVRKCINRNLLTNNQLTSNA---CVG 224

Human   601 KRVRYRSCNLEDCPDNNGKTFREEQCEAHN--EFSKASFGSGPAVEWIPKYAGVSPKDRCKLICQ 663
            ...||:.||...| |.....||..||.|:|  ||      .|....|.|.   |.....|:|.|.
  Fly   225 YFKRYQLCNDVPC-DEQSPDFRASQCSAYNDKEF------HGHRYRWEPY---VKDDAECELNCM 279

Human   664 AKGIGYFFVLQPKVVDGTPCSPDS---------TSVCVQGQCVKAGCDRIIDSKKKFDKCGVCGG 719
            ..|:..|..|...|:|||||...:         .:|||.|.|........||..........|| 
  Fly   280 PFGMKSFATLNESVIDGTPCGHPAEYFRSQFWERAVCVDGACKAVQASGEIDGLYAHSGSVSCG- 343

Human   720 NGSTCKKISGSVTS---AKPGYHDIITIPTGATNIEVKQRNQRGSRNNGSFLAIKAADGTYILNG 781
             |..|:.::|..|.   .:..|..:.|:|.||:||.:.:     .:|:.:.|.::.::...|.||
  Fly   344 -GLLCRPVTGIFTRNPLPEHAYIHVTTLPVGASNISITE-----LKNSINLLVLRTSNELAIFNG 402

Human   782 DYTLSTLEQDIMYK--GVVLRY------SGSSAALERIRSFSPLKEPLTIQVLTVGNALRPKIKY 838
            :.|:|   :...|:  |.|..|      ..|:...|.|.|..|:::.|.:.|.| .:|....:||
  Fly   403 ENTVS---ESGSYEAVGAVFDYHRIDGAEDSNGVTEWITSIGPIRDSLQLMVFT-KSANNTGVKY 463

Human   839 TYFVKKKKES----------------------------------FNAIPTFSAWVIEEWGECSKS 869
            .|.:....||                                  ||       |.:..:..|:||
  Fly   464 EYMLPIVSESEENEMSLESSDGLLRSGMEDTSSSSSSRAGRKRIFN-------WKVIGFSSCTKS 521

Human   870 CELGWQRRLVECRDINGQP-----ASECAKEVKPA---STRPCADHPCP-QWQLGEWSSCSKTCG 925
            |..|.|..::.|  |...|     ...|...|||.   :...|...||| .|:..:|..|..:..
  Fly   522 CGGGTQTPIIRC--IRKNPLRYYSQRRCTHSVKPVLNENLLHCNTQPCPAYWRFDDWGECRCSSS 584

Human   926 KGYKKRSLKCLSH-DGGVLSH-------ESCDPLKK----PKH 956
            .|.::|.:.|:.. ..|::.|       |...|::|    ||:
  Fly   585 GGLRRREVSCVQELASGLVIHVDKAACMEDQPPMQKQCECPKN 627

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
ADAMTS1NP_008919.3 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..27
Pep_M12B_propep 59..166 CDD:460254
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 192..250
Cysteine switch. /evidence=ECO:0000250 196..203
ZnMc_ADAMTS_like 258..463 CDD:239801 29/171 (17%)
ADAMTS_CR_2 478..546 CDD:465496 3/67 (4%)
TSP1 562..614 CDD:214559 22/58 (38%)
ADAMTS_CR_3 <658..724 CDD:437068 22/74 (30%)
Spacer 725..849 34/168 (20%)
ADAMTS_spacer1 726..842 CDD:461796 32/126 (25%)
TSP1_ADAMTS 858..909 CDD:465950 15/58 (26%)
TSP1_ADAMTS 912..>954 CDD:465950 11/53 (21%)
lohNP_609406.2 TSP1 182..238 CDD:214559 23/59 (39%)
ADAMTS_spacer1 349..468 CDD:461796 32/127 (25%)
TSP1_ADAMTS 510..567 CDD:465950 15/58 (26%)
TSP1_ADAMTS 664..715 CDD:465950
TSP1_ADAMTS 720..768 CDD:465950
TSP1_ADAMTS 779..835 CDD:465950
PLAC 847..877 CDD:462560
Blue background indicates that the domain is not in the aligned region.

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