Protein Alignment SCARB2 and CG7227

DIOPT Version :10

• Sequence 1: NP_005497.1
• Gene: SCARB2 / 950
• HGNCID: 1665
• Length: 478
• Species: Homo sapiens
• Sequence 2: NP_609169.1
• Gene: CG7227 / 34088
• FlyBaseID: FBgn0031970
• Length: 518
• Species: Drosophila melanogaster
• Alignment Length: 466
• Identity: 129/466 - (27%)
• Similarity: 221/466 - (47%)
• Gaps: 35/466 - (7%)

Human    11 TLSLLLLVTSVTLLVARVFQKAVDQSIEKKIVLRNGTEAFDSWEKPPLPVYTQFYFFNVTNPEEI 75
            |..|.||:.|.:|......::.....:|..:|||.||.....|:.|.:.:....|.||.||.|:.
  Fly    10 TSVLGLLLASFSLFSVLYMEQIERWMLEWFMVLRPGTMISSLWQSPAMDINVDLYIFNWTNSEKF 74

Human    76 LRGET-PRVEEVGPYTYRELRNKANIQFGDNGTTISAVSNKAYVFERDQSVGDPKIDLIRTLNIP 139
            ..... ||.||:|||.:.|...|.|:::.|..:|:|......:.|:...|||.| .|.|...|:.
  Fly    75 SDPTVKPRFEELGPYRFTERMQKVNVEWHDENSTVSYRRRSRFDFDPKLSVGRP-TDPIVAPNLL 138

Human   140 VL----TVIEWSQVHFLREIIEAMLKAY-QQKLFVTHTVDELLWGYKDEILSLIHVFRPDISP-- 197
            ::    .::.||.:  ||.::...|..| :::..:....|.:..|:...::.:..:..|.:.|
  Fly   139 IVGLYQKMVMWSPM--LRSLMLLALNIYGKEQAMIRPASDWMFDGFDTPMIKMSKMVPPSLVPEM 201

Human   198 -----YFGLFYEKNGTND--GDYVFLTGEDSYLNFTKIVEW--NGKTSLDWWITDKCNMINGTDG 253
                 ..|..|.:||:.:  |.:...||.|.:....:|..|  |..|.    .:.:|. :.|:.|
  Fly   202 KFPYEKIGYAYPRNGSMEIYGHHNVYTGRDEFQKLGQIARWRYNNVTE----ASPRCK-LKGSAG 261

Human   254 DSFHPL-ITKDEVLYVFPSDFCRSVYITFSDYESVQGLPAFRYKVPAEILANTSDNA-GFCIPEG 316
            : |||: :.|...:..|..|.||.:.:.:|.....:|:.||.|:..|..:||.:||. ..|..:.
  Fly   262 E-FHPIPLVKGRPISYFLPDLCRELQVDYSGTTIFEGIDAFVYRGSARNMANGTDNPDNSCYCQD 325

Human   317 NC--LGSGVLNVSICKNGAPIIMSFPHFYQADERFVSAIEGMHPNQEDHETFVDINPLTGIILKA 379
            ||  :.||:||:|.|..|.|:..|:|||::||..:...:|||.|:::.||..:.:.|.||::|:.
  Fly   326 NCQEVRSGLLNISSCWYGTPVFASYPHFFKADPYYGEQVEGMKPDKDRHEMVIMLEPKTGMVLEI 390

Human   380 AKRFQINIYVKKLDDFVETGDIRTMVFPVMYLNESVHIDKETASRLKSMINTTLIITNIPYIIMA 444
            ..|...|:.|:.....:.....||. ||:::.:.:|.|..:....:|.|    .|:..:..|...
  Fly   391 KARIMANLLVEPKTHLIYRTARRTF-FPLIWADYNVRITDDLLVYVKLM----PILEFVGKICGI 450

Human   445 LGVFFGLVFTW 455
            |||..||:..:
  Fly   451 LGVVLGLLMVF 461

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SCARB2	NP_005497.1	CD36	28..457	CDD:460076	123/449 (27%)
		Important for interaction with GBA1	155..191		4/36 (11%)
CG7227	NP_609169.1	CD36	12..463	CDD:460076	128/464 (28%)