DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment MYOT and klg

DIOPT Version :9

Sequence 1:NP_006781.1 Gene:MYOT / 9499 HGNCID:12399 Length:498 Species:Homo sapiens
Sequence 2:NP_524454.2 Gene:klg / 42707 FlyBaseID:FBgn0017590 Length:545 Species:Drosophila melanogaster


Alignment Length:397 Identity:93/397 - (23%)
Similarity:141/397 - (35%) Gaps:106/397 - (26%)


- Green bases have known domain annotations that are detailed below.


Human    76 HAGSNPGQRVTTTYNQSPASFLSSILPSQPDYNSSKIPSAMDSNYQQSSAGQPINAKPSQTANAK 140
            ||||              ..|......|....||..:     ||.|||:.     |..:.||.  
  Fly    61 HAGS--------------GGFAVEAAISNRGSNSRSM-----SNVQQSAV-----AASTLTAT-- 99

Human   141 PIPR--TPDHEIQGSKEALIQDLERKLKCKDTLLHN--------------GNQRLTYEEKMARRL 189
             :||  :..|    :..|::.| ...|.|:...|.|              .|..:|.:|::  ||
  Fly   100 -LPRFLSRGH----TYRAVVGD-TLVLPCQVENLGNFVLLWRRGTNVLTASNIMVTRDERV--RL 156

Human   190 LGPQNAAAVFQAQDDSG---AQDSQQHNSEHARLQVPTSQVRSRSTSRGDVNDQDAIQEKFYPPR 251
            :...|.........|:|   .|.|.:.|    |.||.|.::                   ..||.
  Fly   157 IDGYNLEISDLEPQDAGDYVCQISDKIN----RDQVHTVEI-------------------LVPPS 198

Human   252 FIQVPEN--MSIDEGRFCRMDFKVSGLPAPDVSWYLNGRTVQSDDLHKMIVSEKGLHSLIFEVVR 314
            ...:|.:  :...:|....::.|.||.|.|.:.|      .:....:|..........|..|.:.
  Fly   199 VRAIPTSGQLQARKGGPITLECKGSGNPVPSIYW------TKKSGANKSTARIGDGPILTLEKLE 257

Human   315 ASDAGAYACVAKNRAGE-ATFTVQLDVLAKEHKRAPMFIYKP--QSKKVL----EGDSVKLECQI 372
            ...||.|.|.|.|..|: .|..::||||           |.|  |.:|..    ||...||.|.:
  Fly   258 RQQAGVYQCTADNGVGDPVTVDMRLDVL-----------YPPDIQVEKSWIHSGEGFEAKLVCIV 311

Human   373 SAIPPPKLFWKRNNEMVQFNTDRISLYQDNTGRVTLLIKDVNKKDAGWYTVSAVNEAGVTTCNTR 437
            .|.|...:.|.:|:..:| :||| .:......|..|.|:.:.::|.|.|:..|.|..|  .....
  Fly   312 FADPVATVSWYQNSFPIQ-STDR-RIMATRANRHMLTIRHIQQEDFGNYSCVADNSLG--RSRKY 372

Human   438 LDVTARP 444
            ::::.||
  Fly   373 MELSGRP 379

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
MYOTNP_006781.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..46
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 64..151 19/76 (25%)
Necessary for interaction with ACTN1 79..150 16/72 (22%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 202..241 9/41 (22%)
Necessary for interaction with ACTA1. /evidence=ECO:0000269|PubMed:12499399 215..498 57/239 (24%)
Necessary for interaction with FLNC 215..493 57/239 (24%)
Ig 249..333 CDD:299845 20/86 (23%)
I-set 250..340 CDD:254352 21/92 (23%)
I-set 349..440 CDD:254352 26/96 (27%)
Ig_Myotilin_C 366..440 CDD:143300 20/73 (27%)
klgNP_524454.2 DUF1370 63..>124 CDD:284518 21/92 (23%)
IG_like 109..195 CDD:214653 21/111 (19%)
Ig 118..191 CDD:143165 18/78 (23%)
IG_like 205..274 CDD:214653 16/74 (22%)
IGc2 213..273 CDD:197706 16/65 (25%)
IGc2 301..367 CDD:197706 21/67 (31%)
FN3 392..486 CDD:238020
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 1 1.100 - - O PTHR45080
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
22.010

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