DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment TBX4 and Tbx4

DIOPT Version :9

Sequence 1:	XP_011523792.1	Gene:	TBX4 / 9496	HGNCID:	11603	Length:	609	Species:	Homo sapiens
Sequence 2:	NP_035666.2	Gene:	Tbx4 / 21387	MGIID:	102556	Length:	552	Species:	Mus musculus

Alignment Length:	553	Identity:	512/553 - (92%)
Similarity:	522/553 - (94%)	Gaps:	8/553 - (1%)

- Green bases have known domain annotations that are detailed below.

Human    64 MLQDKGLSESEEAFRAPGPALGEA---SAANAPEPALAAPGLSGAALGSPPGPGADV--VAAAAA 123
            ||||||||||||||||||||||||   |..||||||||.||||||||.||||.||||  .|||||
Mouse     1 MLQDKGLSESEEAFRAPGPALGEASNTSTTNAPEPALATPGLSGAALSSPPGQGADVAAAAAAAA 65

Human   124 EQTIENIKVGLHEKELWKKFHEAGTEMIITKAGRRMFPSYKVKVTGMNPKTKYILLIDIVPADDH 188
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Mouse    66 EQTIENIKVGLHEKELWKKFHEAGTEMIITKAGRRMFPSYKVKVTGMNPKTKYILLIDIVPADDH 130

Human   189 RYKFCDNKWMVAGKAEPAMPGRLYVHPDSPATGAHWMRQLVSFQKLKLTNNHLDPFGHIILNSMH 253
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Mouse   131 RYKFCDNKWMVAGKAEPAMPGRLYVHPDSPATGAHWMRQLVSFQKLKLTNNHLDPFGHIILNSMH 195

Human   254 KYQPRLHIVKADENNAFGSKNTAFCTHVFPETSFISVTSYQNHKITQLKIENNPFAKGFRGSDDS 318
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Mouse   196 KYQPRLHIVKADENNAFGSKNTAFCTHVFPETSFISVTSYQNHKITQLKIENNPFAKGFRGSDDS 260

Human   319 DLRVARLQSKEYPVISKSIMRQRLISPQLSATPDVGPLLGTHQALQHYQHENGAHSQL--AEPQD 381
            ||||||||||||||||||||||||:|.||||.|||.||...||||||||:|||||.|.  |||||
Mouse   261 DLRVARLQSKEYPVISKSIMRQRLVSSQLSAKPDVSPLHSAHQALQHYQYENGAHMQFAAAEPQD 325

Human   382 LPLSTFPTQRDSSLFYHCLKRRADGTRHLDLPCKRSYLEAPSSVGEDHYFRSPPPYDQQMLSPSY 446
            |||:|||||||||||||||||| |..|||||||||||||.|||||:|||||||||||||||||||
Mouse   326 LPLNTFPTQRDSSLFYHCLKRR-DSARHLDLPCKRSYLETPSSVGDDHYFRSPPPYDQQMLSPSY 389

Human   447 CSEVTPREACMYSGSGPEIAGVSGVDDLPPPPLSCNMWTSVSPYTSYSVQTMETVPYQPFPTHFT 511
            |||||||||||||.|||||||||.|||||||||||||||||||||||||||||||||||||.|||
Mouse   390 CSEVTPREACMYSSSGPEIAGVSAVDDLPPPPLSCNMWTSVSPYTSYSVQTMETVPYQPFPAHFT 454

Human   512 ATTMMPRLPTLSAQSSQPPGNAHFSVYNQLSQSQVRERGPSASFPRERGLPQGCERKPPSPHLNA 576
            |||:||||||::|||:|||||||||||||||||||||||||||||||||||..|||||||||||.
Mouse   455 ATTVMPRLPTIAAQSAQPPGNAHFSVYNQLSQSQVRERGPSASFPRERGLPGMCERKPPSPHLNT 519

Human   577 ANEFLYSQTFSLSRESSLQYHSGMGTVENWTDG 609
            ||||||||:|||:||||||||||||||||||||
Mouse   520 ANEFLYSQSFSLTRESSLQYHSGMGTVENWTDG 552

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
TBX4	XP_011523792.1	TBOX	129..318	CDD:238106	188/188 (100%)
Tbx4	NP_035666.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..50		41/48 (85%)
Tbx4	NP_035666.2	TBOX	71..260	CDD:238106	188/188 (100%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C83972783
Domainoid	1	1.000	560	1.000	Domainoid score	I5959
eggNOG	1	0.900	-	-		E1_KOG3585
HGNC	1	1.500	-	-
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H7968
Inparanoid	1	1.050	1049	1.000	Inparanoid score	I5406
Isobase	0	0.000	Not matched by this tool.
NCBI	1	1.000	-	-
OMA	1	1.010	-	-		QHG39057
OrthoDB	1	1.010	-	-		D116549at32523
OrthoFinder	1	1.000	-	-		FOG0010559
OrthoInspector	1	1.000	-	-		oto115297
orthoMCL	1	0.900	-	-		OOG6_116091
Panther	1	1.100	-	-	LDO	PTHR11267
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R9577
SonicParanoid	1	1.000	-	-		X8050
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	18	18.300