DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment SCARB1 and dsb

DIOPT Version :9

Sequence 1:	NP_001354910.1	Gene:	SCARB1 / 949	HGNCID:	1664	Length:	552	Species:	Homo sapiens
Sequence 2:	NP_001097477.1	Gene:	dsb / 38252	FlyBaseID:	FBgn0035290	Length:	615	Species:	Drosophila melanogaster

Alignment Length:	528	Identity:	137/528 - (25%)
Similarity:	245/528 - (46%)	Gaps:	51/528 - (9%)

- Green bases have known domain annotations that are detailed below.

Human    13 ALGVAGLLCAVLGAVMIVMVPSLIKQQVLKNVRIDPSSLSFNMWKEIPIPFYLSVYFFDVMNPSE 77
            |:.:.|::..:||.::..|  ..:...:|||:|:...:||::.|:...:.....:|.::|.||..
  Fly    81 AVIIIGIITLILGIILSSM--PWLDYFILKNLRLWNDTLSYHYWQRPGVIRLTKLYIYNVTNPDG 143

Human    78 ILKGEKPQVRERGPYVYREFRHKSNITFN-NNDTVSFLEYRTFQFQPSKSHGSESDYIVMPNILV 141
            .|:||||.::|.||:||||...|.|:.|: ||.|||:...:..||.|..|...::. |..|||.:
  Fly   144 FLRGEKPHLQEVGPFVYREDMQKVNVKFHENNYTVSYQHKKILQFVPELSIDKDTP-ITTPNIPL 207

Human   142 LGAAVMMENKPMTLKLIMTLAFTTLGERAFMNRTVGEIMWGYKDPLVNLINKYFPGMFPFKDKFG 206
            |....:.......|...:::..|....:.|:|.|..::.:||.|.||:|.::::|......::.|
  Fly   208 LTLTSLSPKLGYLLSKTISVVVTAAQFKPFINVTAEQLAFGYDDALVSLAHRFYPKHMRPMERMG 272

Human   207 LFAELNNSDSGLFTVFTGVQNISRIHLVDKWNGLSKVDFWHSDQCNMINGTSGQMWPP-FMTPES 270
            |....|.:.:.:.:|.||:.::.:...:|:.|||..:..|....|..|.|:.|..:|| .:|...
  Fly   273 LLLGRNGTLTEVSSVKTGMDSMDQFGYIDQLNGLDHLPHWSEPPCTSIAGSEGSFFPPRELTKSE 337

Human   271 SLEFYSPEACRSMKLMYKESGVFEGIPTYRFVAPKTLFANGSIYPPNEGFCPCLES-------GI 328
            .:..|..:.||.:.|.|.||...:||....|..|...:.:.:..|.|:    |.::       |:
  Fly   338 VVHIYDKDLCRIIPLKYVESLEKDGIAADLFRLPNNSYGDSAHNPENK----CYDTSEYEPIQGL 398

Human   329 QNVSTCRFSAPLFLSHPHFLNADPVLAEAVTGLHPNQEAHSLFLDIHPVTGIPMNCSVKLQLSLY 393
            ||:|.|::.||:::|:|||..:.|.|..:|.||.|.:|.|..:..|.|..|:|:...|::||:|.
  Fly   399 QNISPCQYGAPVYISNPHFFESHPDLLNSVEGLKPEREKHETYFKIQPKLGVPLEGKVRIQLNLK 463

Human   394 MKSVAGIGQTGKIEPVVLPLLWFAES-GAMEGETLHTFYTQLVLMPKVMHYAQYVLLALGCVLLL 457
            :.....:.........|.|::|..|. ..:........|...|:.|..:....|:::..|...::
  Fly   464 VTRAKDVYPVRDFRDFVFPVMWLEEGISELTPAIKRWIYLGTVIAPSAVPIGSYLMILGGAFAII 528

Human   458 VPVICQIRSQVGA----------GQRAAR-----------------ADSHSL-------ACWGKG 488
            ...:...::.:.|          |:|:.|                 .||:||       .|.|:|
  Fly   529 FSFVRAYQNFMFAQDPTLEILEMGRRSLRRGSSFIAHQQHRLLVHHRDSYSLLRHGPMATCLGEG 593

Human   489 ASDRTLWP 496
            ..:....|
  Fly   594 NREEDAQP 601

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
SCARB1	NP_001354910.1	None
dsb	NP_001097477.1	CD36	103..532	CDD:279474	120/433 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165148209
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3776
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG45589
OrthoDB	1	1.010	-	-		D1106566at2759
OrthoFinder	1	1.000	-	-		FOG0000618
OrthoInspector	1	1.000	-	-		mtm8581
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11923
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X155
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	9	8.860