Protein Alignment ONECUT2 and onecut

DIOPT Version :10

• Sequence 1: NP_004843.2
• Gene: ONECUT2 / 9480
• HGNCID: 8139
• Length: 504
• Species: Homo sapiens
• Sequence 2: NP_524842.2
• Gene: onecut / 45816
• FlyBaseID: FBgn0028996
• Length: 1081
• Species: Drosophila melanogaster
• Alignment Length: 690
• Identity: 208/690 - (30%)
• Similarity: 258/690 - (37%)
• Gaps: 358/690 - (51%)

Human   137 SSPPGMGMSNT-YTTLTPLQPLPPISTVSDKFHHPHPHHHPHHHHHHHHQRLSGNVSGSFTLMRD 200
            |||   |.|.| |.||||:||||||||:|:||.:                  ||::||..:...|
  Fly   327 SSP---GFSQTSYATLTPIQPLPPISTMSEKFAY------------------SGHISGGDSGDTD 370

Human   201 ER------GLPAMNNLYSPYKEMPGMSQSLSPLAAT-----------------PLGN---GLGGL 239
            ..      |:..:..:.:...|..| :.|:|...||                 |:|:   |||.|
  Fly   371 VNGDGAGGGVVEVGEVTNQSSEATG-TVSISSGNATSSVCSNNDCSSFSALSMPIGSGHLGLGVL 434

Human   240 HNAQQSLPNY-------GPPGHDKMLSPNFDAH-------------------------------- 265
            ...|....:|       .||.::.::|  .|.|
  Fly   435 SGVQSPFSSYEKLSSMISPPPNNYLVS--CDLHSSVSGRVINSSHLQLSHNGNKKESGTHEHTHR 497

Human   266 ----------HTAMLTRGE-----------------------------------QHLSRG----- 280
                      :|..::||:                                   .|:|.|
  Fly   498 PADVNGGKFSYTGHISRGDSVDNDVNGEKFSFSDHISGGDSGDEDANREKFIYSDHISEGENGPD 562

Human   281 ---------------------------------------LGTPPA--AMMSHL------------ 292
                                                   |..|||  ::..||
  Fly   563 VNSGTNWLQMHSEREVRLHMPVPAELEARFHISSERRTRLNVPPARGSLSRHLAPNAPICPADWK 627

Human   293 -----------------------------------------NGLHHPGH--------TQSHGPVL 308
                                                     |....|||        :|....|:
  Fly   628 ADDWKHSNAGVVSLTADMPVVVSLTPTPPPLRDDSVSGIKQNERSSPGHREQYFLDKSQEPSSVV 692

Human   309 APS---------------RERPPSS------------------------SSG----SQVATSGQL 330
            |..               .::.||:                        |||    :::|.|..:
  Fly   693 ADQCSPGINGTPQSVCVIHQQSPSALGNGFQSSSQQAKVSSCASPKGTVSSGGAVSNRIANSSDM 757

Human   331 EEINTKEVAQRITAELKRYSIPQAIFAQRVLCRSQGTLSDLLRNPKPWSKLKSGRETFRRMWKWL 395
            ||||||::||||:||||||||||||||||||||||||||||||||||||||||||||||||:|||
  Fly   758 EEINTKDLAQRISAELKRYSIPQAIFAQRVLCRSQGTLSDLLRNPKPWSKLKSGRETFRRMYKWL 822

Human   396 QEPEFQRMSALRLAA-------------------------------------------------- 410
            ||||||||||||:||
  Fly   823 QEPEFQRMSALRMAAAQIPQRAPLSSGMSLGSATGPSGSTGTIPTDLDPHGGPTMIQNPLTNESD 887

Human   411 ------------------CKRKEQEPNKDRNNSQKKSRLVFTDLQRRTLFAIFKENKRPSKEMQI 457
                              |:||| ||..::....||.||||||||||||.|||||.||||||||:
  Fly   888 SSPASTPVTSVLVGSVVSCRRKE-EPQIEQMPQPKKPRLVFTDLQRRTLQAIFKETKRPSKEMQV 951

Human   458 TISQQLGLELTTVSNFFMNARRRSLEKWQDDLSTGGSSST 497
            ||::|||||.|||.||||||||||::||:||    .|.||
  Fly   952 TIARQLGLEPTTVGNFFMNARRRSMDKWRDD----DSKST 987

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ONECUT2	NP_004843.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	29..95
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	166..189		2/22 (9%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	274..332		23/242 (10%)
		CUT	331..403	CDD:460543	67/71 (94%)
		HOX	426..481	CDD:197696	45/54 (83%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	485..504		6/13 (46%)
onecut	NP_524842.2	CUT	756..830	CDD:460543	67/73 (92%)
		HOX	920..975	CDD:197696	45/54 (83%)