Protein Alignment CD36 and CG2736

DIOPT Version :10

• Sequence 1: NP_000063.2
• Gene: CD36 / 948
• HGNCID: 1663
• Length: 472
• Species: Homo sapiens
• Sequence 2: NP_611991.1
• Gene: CG2736 / 37998
• FlyBaseID: FBgn0035090
• Length: 507
• Species: Drosophila melanogaster
• Alignment Length: 432
• Identity: 97/432 - (22%)
• Similarity: 169/432 - (39%)
• Gaps: 78/432 - (18%)

Human    66 WIFDVQNPQEVMM-NSSNIQVKQRGPYTYRVRFLAKENVTQDAEDNTVSFLQPNGAIFE--PSLS 127
            ::|:|.|.:|... ..|.::||:.||..||:   ...|...|..:..|.:.:....:.|  |..|
  Fly    63 YVFNVTNAEEFRSGRDSRLKVKEIGPIVYRI---VGFNDILDRNETNVRYRKHRYRVVEFLPEES 124

Human   128 VGTEADNFTVL---NLAVAAASHIYQNQ------FVQMILNSLINKSKSSMFQVRTLRELLWGYR 183
            |..:..|:|:.   |:.:.||:.:....      |...::       ...:|...::...||.:.
  Fly   125 VAPDVLNWTITSTNNVILGAATKVKHTAPLAAFGFDAALM-------MEDIFVTDSVYYFLWEFT 182

Human   184 DPFLSLVP--YPVTTTVGLFYPYNNTADGVYKVFNG-KDNISKVAIIDTYKGK--------RNLS 237
            .|.|..:.  ..:...|.:.|......:.||.|..| |..|.....|:|..|:        ....
  Fly   183 RPLLQTLSRISNIRPNVAVLYNALKEKEEVYTVNIGPKRGIENFFRIETLNGEVIIREQLPHTRQ 247

Human   238 YWESHCDM-INGT-DAASFPPFVEKSQVLQFFSSDICRSIYAVFESDVNLKGIPVYRFVLPSKAF 300
            |..:.|.. ::|. |.:.|||||:....|...:.:.||.:...::......|:..:|:.|    .
  Fly   248 YDSNSCPFNVSGALDNSLFPPFVQPDTPLSIVAIESCRVLPLTYQRQERYNGLDTFRYTL----L 308

Human   301 ASPVENPDNYCFCTEKIISKNCTSYGV------LDISKCK-EGRPVYISLPHFLYASPDVSEPID 358
            .|..:.|.    |.:       |||||      .|:|:|. ...|...|:|||..:|.:.|:..:
  Fly   309 QSHQKPPG----CLD-------TSYGVKLPDGMFDVSQCVINDAPSAFSMPHFYGSSYNWSQHYE 362

Human   359 GLNPNEEEHRTYLDIEPITGFTLQFAKRLQVNLLVKPSEKIQVLKNLKRNYIVPILWLN-ETGTI 422
            |..||.|:|..|:.:||:||..:....|.|.|:.:....:.....:...|.::|..|.. |.|
  Fly   363 GYTPNAEDHEPYILLEPVTGIPVTEKYRFQSNIPIPDLRRFSSRLSRFSNMMIPSFWYEFEMG-- 425

Human   423 GDEKANMFRSQVTGKINLLGLIEMILLSVGVVMFVAFMISYC 464
                      |:.|.:.     .::.::|.:|..:.   .||
  Fly   426 ----------QLPGFVT-----SLMWINVNIVQHIQ---PYC 449

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CD36	NP_000063.2	CD36	14..463	CDD:460076	95/429 (22%)
		Required for interaction with thrombospondins, THBS1 and THBS2. /evidence=ECO:0000269|PubMed:1371676	93..120		5/26 (19%)
		Interaction with PTK2, PXN and LYN. /evidence=ECO:0000269|PubMed:20037584	460..472		2/5 (40%)
CG2736	NP_611991.1	CD36	10..464	CDD:460076	97/432 (22%)