DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CD36 and santa-maria

DIOPT Version :9

Sequence 1:	NP_000063.2	Gene:	CD36 / 948	HGNCID:	1663	Length:	472	Species:	Homo sapiens
Sequence 2:	NP_609121.2	Gene:	santa-maria / 34024	FlyBaseID:	FBgn0025697	Length:	563	Species:	Drosophila melanogaster

Alignment Length:	491	Identity:	130/491 - (26%)
Similarity:	242/491 - (49%)	Gaps:	39/491 - (7%)

- Green bases have known domain annotations that are detailed below.

Human     2 GCDRNCGLIAGAVIGAVLAVFGGILMPVGDLLIQKTIKKQVVLEEGTIAFKNWVKTGTEVYRQFW 66
            |...|..||.| :.|..|.:||.:.......|....:.|::.|...|..::||.....::....:
  Fly    10 GQKSNRKLIIG-IFGFCLGLFGILCGMFWVDLFDWIMHKEMALAPDTRVYENWKSPPIDLSLDIY 73

Human    67 IFDVQNPQEVMMNSSNIQVKQRGPYTYRVRFLA---KENVTQDAEDNTVSFLQPNGAIFEPSLSV 128
            :::..||::....|:...::|.|||    ||:.   |.::....|:.:|::.:.:...|:.:.|.
  Fly    74 LYNWTNPEDFGNLSTKPILEQVGPY----RFIERPDKVDIHWHPENASVTYRRRSLFYFDAAGSN 134

Human   129 GTEADNFTVLNLAV--AAASHIYQNQFVQMILNSLINKSKSSMFQVRTLRELLW-GYRDPFLSL- 189
            |:..|..|.||...  |||:..|.....:.:::..:....:.|...:::.|||: ||.|..:.:
  Fly   135 GSLDDEITTLNAVALSAAATAKYWPPVKRSLVDVGLKMYGAEMSVQKSIDELLFTGYNDAMIDVA 199

Human   190 -----------VPYPVTTTVGLFYPYNNTAD--GVYKVFNGKDNISKVAIIDTYKGKRNLSYWES 241
                       ||:   ...|.||..|.:||  ||:.||.|.|.::|:..:.::..:.|..:::|
  Fly   200 MAMPIFGDEVKVPF---DKFGWFYTRNGSADLTGVFNVFTGADQLAKLGQMHSWNYQENTGFFDS 261

Human   242 HCDMINGTDAASFPPFVEKSQVLQFFSSDICRSIYAVFESDVNLKGIPVYRFVLPSKAFASPVEN 306
            :|.|.||:.....|..::....:..|:.|:||:|...:...|:::|:..|:|....::..:..:.
  Fly   262 YCGMTNGSAGEFQPQHLKPGDSVGLFTPDMCRTIPLDYVETVDIEGLEGYKFSGGPRSVDNGTQY 326

Human   307 PDNYCFCTEKIISKNCTSYGVLDISKCKEGRPVYISLPHFLYASPDVSEPIDGLNPNEEEHRTYL 371
            |:|.|||     ...|...||::||.|:.|.||::|.|||..|.|...:.::||:||:::|..|:
  Fly   327 PENLCFC-----GGQCVPSGVMNISSCRFGSPVFMSYPHFFNADPYYPDQVEGLSPNQKDHEFYM 386

Human   372 DIEPITGFTLQFAKRLQVNLLVKPSEKIQVLKNLKRNYIVPILWLNETGTIGDEKANMFRSQVTG 436
            .::|.||..|:.|.|.|||:||:|.:.|.:...:.|.:. |::|..:...|..:.|:..:  |..
  Fly   387 VVQPSTGIPLEVAARFQVNMLVEPIQGISLYTGIPRIFF-PLVWFEQKVRITPDMADQLK--VLP 448

Human   437 KINLLG-LIEMILLSVGVVM--FVAFMISYCACRSK 469
            .:.|.| :...|.|.||:.:  :....|...:||::
  Fly   449 IVMLSGHIFAGICLIVGITLLCWTPVQILLASCRNR 484

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CD36	NP_000063.2	CD36	14..463	CDD:395898	123/471 (26%)
		Required for interaction with thrombospondins, THBS1 and THBS2. /evidence=ECO:0000269\|PubMed:1371676	93..120		5/29 (17%)
		Interaction with PTK2, PXN and LYN. /evidence=ECO:0000269\|PubMed:20037584	460..472		3/10 (30%)
santa-maria	NP_609121.2	CD36	23..474	CDD:279474	122/465 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3776
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	1.030639	Normalized mean entropy	S6187
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1106566at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X155
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	5	4.770