DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment ROCK2 and Rok

DIOPT Version :9

Sequence 1:XP_005246247.1 Gene:ROCK2 / 9475 HGNCID:10252 Length:1417 Species:Homo sapiens
Sequence 2:NP_536796.2 Gene:Rok / 43916 FlyBaseID:FBgn0026181 Length:1390 Species:Drosophila melanogaster


Alignment Length:1433 Identity:622/1433 - (43%)
Similarity:870/1433 - (60%) Gaps:108/1433 - (7%)


- Green bases have known domain annotations that are detailed below.


Human    10 MPGAPETAPGD-GAGASRQRK---LEALIRDPRSPINVESLLDGLNSLVLDLDFPALRKNKNIDN 70
            ||...||.... .....|:|:   ||..:|||.|..||:.|||.:::||.|.|..:||:.|||:.
  Fly     1 MPAGRETVTKQRSMDVERRRRANTLEREMRDPTSICNVDCLLDTVSALVSDCDHESLRRLKNIEQ 65

Human    71 FLNRYEKIVKKIRGLQMKAEDYDVVKVIGRGAFGEVQLVRHKASQKVYAMKLLSKFEMIKRSDSA 135
            :..:|:.:..:|..|:|..||:..:|:||.||||||||||||:|.:|||||.||||||:||.|||
  Fly    66 YAAKYKPLAMQINQLRMNVEDFHFIKLIGAGAFGEVQLVRHKSSSQVYAMKRLSKFEMMKRPDSA 130

Human   136 FFWEERDIMAFANSPWVVQLFYAFQDDRYLYMVMEYMPGGDLVNLMSNYDVPEKWAKFYTAEVVL 200
            ||||||.|||.|||.|:|||.:||||.:||||||::|||||:|:||.:||:|||||.|||.||||
  Fly   131 FFWEERHIMAHANSEWIVQLHFAFQDAKYLYMVMDFMPGGDIVSLMGDYDIPEKWAIFYTMEVVL 195

Human   201 ALDAIHSMGLIHRDVKPDNMLLDKHGHLKLADFGTCMKMDETGMVHCDTAVGTPDYISPEVLKSQ 265
            |||.||:||.:||||||||||||.:||||||||||||:|...|.|....|||||||||||||:||
  Fly   196 ALDTIHNMGFVHRDVKPDNMLLDSYGHLKLADFGTCMRMGANGQVVSSNAVGTPDYISPEVLQSQ 260

Human   266 GGDGFYGRECDWWSVGVFLYEMLVGDTPFYADSLVGTYSKIMDHKNSLCFPEDAEISKHAKNLIC 330
            |.|..|||||||||||:||||||.|:||||||||||||.|||||||||.||.:.|||:.||.||.
  Fly   261 GVDNEYGRECDWWSVGIFLYEMLFGETPFYADSLVGTYGKIMDHKNSLSFPPEVEISEQAKALIR 325

Human   331 AFLTDREVRLGRNGVEEIRQHPFFKNDQWHWDNIRETAAPVVPELSSDIDSSNFDDIEDDKGDVE 395
            ||||||..||||.|:|:|:.||||:||.|.:|||||:..|||||||||.|:.||:|||.|:...|
  Fly   326 AFLTDRTQRLGRYGIEDIKAHPFFRNDTWSFDNIRESVPPVVPELSSDDDTRNFEDIERDEKPEE 390

Human   396 TFPIPKAFVGNQLPFIGFTYYRENLLLSDSPSCRETDSIQSRKNEESQEIQKKLYTLEEH----- 455
            .||:||.|.||.||||||||..:..|||       :|::.:...|.:............|     
  Fly   391 VFPVPKGFDGNHLPFIGFTYTGDYQLLS-------SDTVDAESKEANVANSGAASNNHGHGHNHR 448

Human   456 ----LSNEMQAKEELEQKCKSVNTRLEKTAKELEEEITLRKSVESALRQL----EREKALLQHKN 512
                .|||::..|.|.::.:..:..||:....|.::|.|....|:.|:::    |::.||.||..
  Fly   449 HRPSNSNELKRLEALLERERGRSEALEQQDAGLRQQIELITKREAELQRIASEYEKDLALRQHNY 513

Human   513 AEYQRKADHE-----------ADKKRNLENDVNSLKDQLEDLKKRNQNSQISTEKVNQLQRQLDE 566
            ....:|.:.|           .:.:|||||:   .|.:..||   |.|     :||..|::||.|
  Fly   514 KVAMQKVEQEIELRKKTEALLVETQRNLENE---QKTRARDL---NIN-----DKVVSLEKQLLE 567

Human   567 TNALLRTESDTAARLRKTQAESSKQIQQLESNNRDLQDKNCLLETAKLKLEKEFINLQSALESER 631
            .....:||::...:|:|..||....::..|...||:.|....|:..|.:|.:|...||:.:..|:
  Fly   568 MEQSYKTETENTQKLKKHNAELDFTVKSQEEKVRDMVDMIDTLQKHKEELGQENAELQALVVQEK 632

Human   632 RDRTHGSEIINDLQGRICGLEEDLKNGKILLAKVELEKRQLQERFTDLEKEKSNMEIDMTYQLKV 696
            ..|:...|:..:.:.::..|..|::.......|.:.:.|.|.|:.:||||..:.::    ::||.
  Fly   633 NLRSQLKEMHKEAENKMQTLINDIERTMCREQKAQEDNRALLEKISDLEKAHAGLD----FELKA 693

Human   697 IQQSLEQEEAEHKAT-KARLADKNKIYESIEEAKSEAMKEMEKKLLEERTLKQKVENLLLEAEKR 760
            .|...:||...|:.| |:||..:       |||..:.:|.::.||.||::.:.|.:....|.|::
  Fly   694 AQGRYQQEVKAHQETEKSRLVSR-------EEANLQEVKALQSKLNEEKSARIKADQHSQEKERQ 751

Human   761 CSLLDCDLKQSQQKINELLKQKDVLNEDVRNLTLKIEQETQKRCLTQNDLKMQTQQVNTLKMSEK 825
            .|:|..|.:|.|.::.:|..:....:|.|..|..:::||..||....::|.:.:.:|..|:..|.
  Fly   752 LSMLSVDYRQIQLRLQKLEGECRQESEKVAALQSQLDQEHSKRNALLSELSLHSSEVAHLRSREN 816

Human   826 QLKQENNHLMEMKMNLEKQNAELRKERQDADGQMKELQDQLEAEQYFSTLYKTQVRELKEECEEK 890
            ||::|.:...|.|...|:...:|:....:|....:|||.||||||.||.|||||..|.:||..|:
  Fly   817 QLQKELSTQREAKRRFEEDLTQLKSTHHEALANNRELQAQLEAEQCFSRLYKTQANENREESAER 881

Human   891 TKLGKELQQKKQELQDERDSLAAQLEITLTKADSEQLARSIAEEQYSDLEKEKIMKELEIKEMMA 955
            .       .|.::|::||.||..|:::.:.:||||.||||||||..:||||||.:||||:|:.:.
  Fly   882 L-------SKIEDLEEERVSLKHQVQVAVARADSEALARSIAEETVADLEKEKTIKELELKDFVM 939

Human   956 RHKQELTEKDATIASLEETNRTLTSDVANLANEKEELNNKLKDVQEQLSRL---KDEEISAAAIK 1017
            :|:.|:..|:|.:|:|:|....|...:...|.|.|:|..:.|..||:|:.:   |||||:....|
  Fly   940 KHRNEINAKEAALATLKEAENELHKKLGQKAAEYEDLVQQHKKQQEELALMRSSKDEEITKLLDK 1004

Human  1018 AQFEKQLLTERTLKTQAVNKLAEIMNR------KEPVKRGNDTDVRRKEKENRKLHMELKSEREK 1076
            .:      .|..||..|||||||:|||      |:..|..:..::|:||||.|:|..||..||:|
  Fly  1005 CK------NEVLLKQVAVNKLAEVMNRRDSDLPKQKNKARSTAELRKKEKEMRRLQQELSQERDK 1063

Human  1077 LTQQMIKYQKELNEMQAQIAEESQIRIELQMTLDSKDSDIEQLRSQLQALHIGLDSSSIGSGPGD 1141
            ..|.::|:|    ::|...|||.|::.::.|.:|.|.::||.|:|:|.      :::|:.|...|
  Fly  1064 FNQLLLKHQ----DLQQLCAEEQQLKQKMVMEIDCKATEIENLQSKLN------ETASLSSADND 1118

Human  1142 AEADDG------FPESRLEGWLSLPVRNNTKK-FGWVKKYVIVSSKKILFYDSEQDKEQ-SNPYM 1198
            .|....      ..:|..|||||:|.:.|.:: .||.::||||||:||:||:|:.||.. ::..:
  Fly  1119 PEDSQHSSLLSLTQDSVFEGWLSVPNKQNRRRGHGWKRQYVIVSSRKIIFYNSDIDKHNTTDAVL 1183

Human  1199 VLDIDKLFHVRPVTQTDVYRADAKEIPRIFQILYANEGESKKEQEFPVEPVG--------EKSNY 1255
            :||:.|::|||.|||.||.||||||||||||:|||.||.|.:..|.....|.        |:...
  Fly  1184 ILDLSKVYHVRSVTQGDVIRADAKEIPRIFQLLYAGEGASHRPDEQSQLDVSVLHGNCNEERPGT 1248

Human  1256 ICHKGHEFIPTLYHFPTNCEACMKPLWHMFKPPPALECRRCHIKCHKDHMDKKEEIIAPCKVYYD 1320
            |.||||||:...||.||.||.|.||||||||||.|.||:||..|.||:|:||.:. :||||:.:|
  Fly  1249 IVHKGHEFVHITYHMPTACEVCPKPLWHMFKPPAAYECKRCRNKIHKEHVDKHDP-LAPCKLNHD 1312

Human  1321 ISTAKNLLLLANSTEEQQKWVSRLVKKIPKKPPAPDPFARSSPRTSMKIQQNQSIRRPSRQLAPN 1385
            ..:|:::||||.:.|:|..||:||:|:|.|.......:..:|...| ||..:||.|...:..|.|
  Fly  1313 PRSARDMLLLAATPEDQSLWVARLLKRIQKSGYKAASYNNNSTDGS-KISPSQSTRSSYKPYAVN 1376

Human  1386 KPR 1388
            ..|
  Fly  1377 VQR 1379

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
ROCK2XP_005246247.1 STKc_ROCK2 39..417 CDD:270771 257/377 (68%)
S_TKc 92..354 CDD:214567 194/261 (74%)
SCP-1 412..1080 CDD:114219 219/701 (31%)
HR1_ROCK2 505..571 CDD:212028 22/76 (29%)
Rho_Binding 979..1046 CDD:286056 27/75 (36%)
PH_ROCK 1151..1257 CDD:269948 55/115 (48%)
C1 1261..1307 CDD:237996 29/45 (64%)
RokNP_536796.2 STKc_ROCK 61..411 CDD:270747 244/349 (70%)
S_TKc 87..349 CDD:214567 194/261 (74%)
SbcC 484..1088 CDD:223496 209/642 (33%)
Rho_Binding 963..1027 CDD:286056 27/69 (39%)
PH_ROCK 1134..1250 CDD:269948 55/115 (48%)
C1 1254..1307 CDD:197519 32/53 (60%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C165143118
Domainoid 1 1.000 416 1.000 Domainoid score I656
eggNOG 1 0.900 - - E2759_KOG0612
Hieranoid 1 1.000 - -
Homologene 1 1.000 - - H21010
Inparanoid 1 1.050 1081 1.000 Inparanoid score I244
Isobase 00.000 Not matched by this tool.
OMA 1 1.010 - - QHG46537
OrthoDB 1 1.010 - - D36370at33208
OrthoFinder 1 1.000 - - FOG0001986
OrthoInspector 1 1.000 - - otm41999
orthoMCL 1 0.900 - - OOG6_104177
Panther 1 1.100 - - O PTHR22988
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R2768
SonicParanoid 1 1.000 - - X1475
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 1 0.960 - -
User_Submission 00.000 Not matched by this tool.
1615.800

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