DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ROCK2 and rock2a

DIOPT Version :9

Sequence 1:	XP_005246247.1	Gene:	ROCK2 / 9475	HGNCID:	10252	Length:	1417	Species:	Homo sapiens
Sequence 2:	NP_777288.1	Gene:	rock2a / 317747	ZFINID:	ZDB-GENE-030115-3	Length:	1375	Species:	Danio rerio

Alignment Length:	1371	Identity:	1041/1371 - (75%)
Similarity:	1203/1371 - (87%)	Gaps:	15/1371 - (1%)

- Green bases have known domain annotations that are detailed below.

Human    25 SRQRKLEALIRDPRSPINVESLLDGLNSLVLDLDFPALRKNKNIDNFLNRYEKIVKKIRGLQMKA 89
            :|.|:|||:|:||||.||:|||||.:|:||||||||||||||||:||||||||::..||.|||:.
Zfish    11 NRLRQLEAMIKDPRSAINLESLLDSMNALVLDLDFPALRKNKNIENFLNRYEKVMNHIRELQMRP 75

Human    90 EDYDVVKVIGRGAFGEVQLVRHKASQKVYAMKLLSKFEMIKRSDSAFFWEERDIMAFANSPWVVQ 154
            ||:|.|||||||||||||||||||||||||||:|||||||||||||||||||||||||:||||||
Zfish    76 EDFDRVKVIGRGAFGEVQLVRHKASQKVYAMKVLSKFEMIKRSDSAFFWEERDIMAFADSPWVVQ 140

Human   155 LFYAFQDDRYLYMVMEYMPGGDLVNLMSNYDVPEKWAKFYTAEVVLALDAIHSMGLIHRDVKPDN 219
            |..||||||.||||||||||||||||.|.||||||||||||||||||||||||||.|||||||||
Zfish   141 LCCAFQDDRSLYMVMEYMPGGDLVNLTSTYDVPEKWAKFYTAEVVLALDAIHSMGFIHRDVKPDN 205

Human   220 MLLDKHGHLKLADFGTCMKMDETGMVHCDTAVGTPDYISPEVLKSQGGDGFYGRECDWWSVGVFL 284
            ||||::|||||||||||||||.||||||||||||||||||||||||||||:|||||||||||||:
Zfish   206 MLLDRYGHLKLADFGTCMKMDGTGMVHCDTAVGTPDYISPEVLKSQGGDGYYGRECDWWSVGVFI 270

Human   285 YEMLVGDTPFYADSLVGTYSKIMDHKNSLCFPEDAEISKHAKNLICAFLTDREVRLGRNGVEEIR 349
            |||||||||||||||||||||||||||||.||:|.|||:..||:||||||||||||||:|||||:
Zfish   271 YEMLVGDTPFYADSLVGTYSKIMDHKNSLNFPDDVEISQEGKNIICAFLTDREVRLGRSGVEEIK 335

Human   350 QHPFFKNDQWHWDNIRETAAPVVPELSSDIDSSNFDDIEDDKGDVETFPIPKAFVGNQLPFIGFT 414
            :||||:||||.:..|||||||||||||||||:||||:||:|||:|||||.|||||||||||:|||
Zfish   336 RHPFFRNDQWTFSTIRETAAPVVPELSSDIDTSNFDEIEEDKGEVETFPTPKAFVGNQLPFVGFT 400

Human   415 YYRENLLLS--DSPSCRETDSIQSRKNEESQEIQKKLYTLEEHLSNEMQAKEELEQKCKSVNTRL 477
            |::||.||:  :|.:.:....:.:|  |::..:||||:.|||.|:||||||:|||||.:|.:.||
Zfish   401 YFKENQLLNAVNSSAMKNDHPVSNR--EDNLALQKKLHCLEEQLNNEMQAKDELEQKYRSNSNRL 463

Human   478 EKTAKELEEEITLRKSVESALRQLEREKALLQHKNAEYQRKADHEADKKRNLENDVNSLKDQLED 542
            ||..|||:||:..||.:||.||||||||||||||:.|..|:|:.|||:||.|||:||||:|||::
Zfish   464 EKITKELDEEMNSRKGLESTLRQLEREKALLQHKSVESHRRAESEADRKRCLENEVNSLRDQLDE 528

Human   543 LKKRNQNSQISTEKVNQLQRQLDETNALLRTESDTAARLRKTQAESSKQIQQLESNNRDLQDKNC 607
            :||:||||.||.||...||:||||.|||||.||:.|.|:||||.|||||:||||::.|:||||.|
Zfish   529 MKKKNQNSHISNEKNIHLQKQLDEANALLRAESEVATRMRKTQTESSKQLQQLEAHVRELQDKCC 593

Human   608 LLETAKLKLEKEFINLQSALESERRDRTHGSEIINDLQGRICGLEEDLKNGKILLAKVELEKRQL 672
            :||.:||.||:|.|:||:||::|:|::|.|||.|:|||.||.|:|::::..:..|:|.|.|||||
Zfish   594 MLENSKLTLERENISLQAALDTEKREQTQGSETISDLQARITGMEDEVRQMRQALSKAETEKRQL 658

Human   673 QERFTDLEKEKSNMEIDMTYQLKVIQQSLEQEEAEHKATKARLADKNKIYESIEEAKSEAMKEME 737
            ||:.||:||||||.:|||||:||::||.||||||.||||||||||||.|.||||.|||||:||:|
Zfish   659 QEKLTDMEKEKSNNQIDMTYKLKMLQQGLEQEEAAHKATKARLADKNMISESIEGAKSEAVKELE 723

Human   738 KKLLEERTLKQKVENLLLEAEKRCSLLDCDLKQSQQKINELLKQKDVLNEDVRNLTLKIEQETQK 802
            :||.|||:.||:|||.:||.||:.|:||||.|||.||:.||.:.|:.|.|:|:||.||||||.||
Zfish   724 QKLQEERSSKQRVENRVLELEKKNSMLDCDYKQSLQKLEELRRHKERLTEEVKNLNLKIEQEVQK 788

Human   803 RCLTQNDLKMQTQQVNTLKMSEKQLKQENNHLMEMKMNLEKQNAELRKERQDADGQMKELQDQLE 867
            |.|||||||:|.||::||:.||||||||.||::|:|.:|||||.||||||||:||||||||||||
Zfish   789 RTLTQNDLKVQNQQLSTLRTSEKQLKQEINHILEIKRSLEKQNMELRKERQDSDGQMKELQDQLE 853

Human   868 AEQYFSTLYKTQVRELKEECEEKTKLGKELQQKKQELQDERDSLAAQLEITLTKADSEQLARSIA 932
            |||||||||||||||||||||||.||.|::||..||||:||||||||||||||||||||||||||
Zfish   854 AEQYFSTLYKTQVRELKEECEEKNKLYKDVQQNLQELQEERDSLAAQLEITLTKADSEQLARSIA 918

Human   933 EEQYSDLEKEKIMKELEIKEMMARHKQELTEKDATIASLEETNRTLTSDVANLANEKEELNNKLK 997
            |||||||||||||||||||||||||:|||.|||.||:||||.|||||||||||||||||.|||||
Zfish   919 EEQYSDLEKEKIMKELEIKEMMARHRQELAEKDTTISSLEEANRTLTSDVANLANEKEEFNNKLK 983

Human   998 DVQEQLSRLKDEEISAAAIKAQFEKQLLTERTLKTQAVNKLAEIMNRKE----PVKRGNDTDVRR 1058
            :.::.|..||:||.|...:|...||||.:||||||||||||||||||||    ..:|||||||||
Zfish   984 EAEDYLQNLKNEEQSITQVKLALEKQLQSERTLKTQAVNKLAEIMNRKEVRGGGSRRGNDTDVRR 1048

Human  1059 KEKENRKLHMELKSEREKLTQQMIKYQKELNEMQAQIAEESQIRIELQMTLDSKDSDIEQLRSQL 1123
            ||||||||.:||:||||||...:||||:|:|::|||:.:|||:||||||.|||||||||||||.|
Zfish  1049 KEKENRKLQLELRSEREKLNSTIIKYQREINDIQAQLLDESQVRIELQMALDSKDSDIEQLRSLL 1113

Human  1124 QALHI-GLDSSSIGSGPGDAEADDGFPESRLEGWLSLPVRNNTKKFGWVKKYVIVSSKKILFYDS 1187
            .:|:: .|||:|:.||| |.:.|:...|.|||||||||||||||:|||.:|||:|||||||||:|
Zfish  1114 NSLNVQSLDSASMSSGP-DMDTDESLLEIRLEGWLSLPVRNNTKRFGWERKYVVVSSKKILFYNS 1177

Human  1188 EQDKEQSNPYMVLDIDKLFHVRPVTQTDVYRADAKEIPRIFQILYANEGESKKEQEFPVEPV-GE 1251
            |||||.||||||||||||||||.|||||||||||||||||||||||||||||||||  :||: |:
Zfish  1178 EQDKEHSNPYMVLDIDKLFHVRSVTQTDVYRADAKEIPRIFQILYANEGESKKEQE--LEPLPGD 1240

Human  1252 KSNYICHKGHEFIPTLYHFPTNCEACMKPLWHMFKPPPALECRRCHIKCHKDHMDKKEEIIAPCK 1316
            ||:|||||||||||||||||||||||.||||:|||||||||||||||||||||||||||:||||:
Zfish  1241 KSSYICHKGHEFIPTLYHFPTNCEACTKPLWNMFKPPPALECRRCHIKCHKDHMDKKEEVIAPCR 1305

Human  1317 VYYDISTAKNLLLLANSTEEQQKWVSRLVKKIPKKPPAPDPFARSSPRTSMKIQQNQSIRRPSRQ 1381
            |  |:||||||||||:|.|:||||||||:|||||||||||...|||||..:|:|.:||:||||||
Zfish  1306 V--DMSTAKNLLLLASSQEDQQKWVSRLMKKIPKKPPAPDAPHRSSPRVPVKVQSSQSMRRPSRQ 1368

Human  1382 LAPNKP 1387
            :...||
Zfish  1369 IPAGKP 1374

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ROCK2	XP_005246247.1	STKc_ROCK2	39..417	CDD:270771	328/377 (87%)
		S_TKc	92..354	CDD:214567	236/261 (90%)
		SCP-1	412..1080	CDD:114219	467/673 (69%)
		HR1_ROCK2	505..571	CDD:212028	43/65 (66%)
		Rho_Binding	979..1046	CDD:286056	47/66 (71%)
		PH_ROCK	1151..1257	CDD:269948	91/106 (86%)
		C1	1261..1307	CDD:237996	43/45 (96%)
rock2a	NP_777288.1	STKc_ROCK2	25..403	CDD:270771	328/377 (87%)
		S_TKc	78..340	CDD:214567	236/261 (90%)
		DUF4631	431..1028	CDD:292090	425/596 (71%)
		HR1_ROCK2	491..557	CDD:212028	43/65 (66%)
		Rho_Binding	965..1032	CDD:286056	47/66 (71%)
		PH_ROCK	1141..1246	CDD:269948	91/106 (86%)
		C1	1250..1304	CDD:237996	50/53 (94%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C194325775
Domainoid	1	1.000	850	1.000	Domainoid score	I699
eggNOG	1	0.900	-	-		E2759_KOG0612
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H21010
Inparanoid	1	1.050	2067	1.000	Inparanoid score	I416
NCBI	1	1.000	-	-
OMA	1	1.010	-	-		QHG46537
OrthoDB	1	1.010	-	-		D29476at7742
OrthoFinder	1	1.000	-	-		FOG0001986
OrthoInspector	1	1.000	-	-		oto44727
orthoMCL	1	0.900	-	-		OOG6_104177
Panther	1	1.100	-	-	LDO	PTHR22988
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2768
SonicParanoid	1	1.000	-	-		X1475
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	1	1.500	-	-
	18	18.300