DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ROCK2 and Nek2

DIOPT Version :9

Sequence 1:	XP_005246247.1	Gene:	ROCK2 / 9475	HGNCID:	10252	Length:	1417	Species:	Homo sapiens
Sequence 2:	NP_572415.1	Gene:	Nek2 / 31696	FlyBaseID:	FBgn0029970	Length:	735	Species:	Drosophila melanogaster

Alignment Length:	622	Identity:	158/622 - (25%)
Similarity:	268/622 - (43%)	Gaps:	143/622 - (22%)

- Green bases have known domain annotations that are detailed below.

Human    86 QMKAEDYDVVKVIGRGAFGEVQLVRHKASQKVYAMKLLSKFEMIKRSDSAFFWEERDIMAFANSP 150
            |...:||:|:.|:|.|:||....||.|::.:::|.|.::..|:.:....|.. .|..::.....|
  Fly    13 QKTLQDYEVLAVMGNGSFGTCYKVRDKSTGELFAWKGMNYDELDEAKCDALV-SEISVLRQLQHP 76

Human   151 WVVQLFYAF--QDDRYLYMVMEYMPGGDLVNLM-------SNYDVPEKWAKFYTAEVVLALDAIH 206
            .:||.::..  ::.:.:|:|||...||||..::       ..::.|..|...:  ::..||...|
  Fly    77 NIVQYYHHLVNREAKSVYIVMECCAGGDLAQIVQRARSQRQRFEEPYIWRVLF--QLCRALQVCH 139

Human   207 SM----GLIHRDVKPDNMLLDKHGHLKLADFGTC--MKMDETGMVHCDTAVGTPDYISPEVLKSQ 265
            :.    .::|||:||.|:.||..|:.||.|||..  ::.|::   ...:.||||.|:|||::|.:
  Fly   140 NKIPNGTILHRDIKPANIFLDAAGNAKLGDFGLARMLRRDQS---FAASFVGTPHYMSPELVKGR 201

Human   266 GGDGFYGRECDWWSVGVFLYEMLVGDTPFYA---DSL-----VGTYSKIMDHKNSLCFPEDAEIS 322
            .    |.|:.|.|:||..:|||.....||..   |.|     .|.:|:|           .|..|
  Fly   202 K----YDRKSDVWAVGCLVYEMCALRPPFRGRAFDQLSEKIAQGEFSRI-----------PAIYS 251

Human   323 KHAKNLICAFL-TDREVRLGRNGVEEIRQHPFFKNDQWHWDNIRETAA--PVVPELSSDI----- 379
            ...:.:|...| .|.|   .|.|:|.|.:||....      ||.|...  |::.:...|.
  Fly   252 TDLQEIIAFMLAVDHE---QRPGIEVIIRHPLVVR------NISELDGKFPILVDSGEDFYTLPS 307

Human   380 DSSNFDDIEDDKGD--------VETFPIPKAFVGNQLPFIG-FT-------YY--------RENL 420
            .:..|:|.|:|...        .|.:...:.:...:|...| ||       :|        .:.|
  Fly   308 GARLFEDEEEDGVHPELSSTMFTEQYSFNEGYGQRRLSVTGVFTPDLRSELFYSAKRKIFPAKKL 372

Human   421 LLSDSPSCRETDSIQSRKNEESQEIQKKLYTLEEHLSNEMQAKEELEQKCKSVNTRLEKTAKELE 485
            .||| ||..|  ||:..:..|.::::         |:.|.:.|::.||         :|..:||
  Fly   373 QLSD-PSLYE--SIRREERAEERQVE---------LAEERRRKKDQEQ---------QKRDQEL- 415

Human   486 EEITLRKSVESALRQLEREKALLQHKNAEYQRKADHEADKKRNLENDVNSLKDQLEDLKKRNQNS 550
                |:::..|       .:||.|:...|..:...|....:.:|      |:.:||:|:.|.|..
  Fly   416 ----LKEAPSS-------PRALTQNIFDEVLKTRLHAIRAQESL------LQQKLEELQTREQEL 463

Human   551 QISTEKVNQLQRQLDETNALLRTESDTAARLRKTQAESSKQIQQLESNNRDLQDKNCLLE----- 610
            |::.::|..|:||:.|  .||:.|..|.: .|:..|......:..:|::   .|..|.:|
  Fly   464 QLAEQRVQTLERQMQE--KLLQQEKHTCS-CRQPIAPPIPPRKPAKSHH---DDTYCTIELNETS 522

Human   611 --TAKLKL-----EKEFINLQS-ALESERRDRTHGSE 639
              .|||.|     .|....|:. ..:|.::..|:|.|
  Fly   523 PTVAKLNLATLPAPKSLNTLRKVTFKSPQKFVTYGIE 559

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ROCK2	XP_005246247.1	STKc_ROCK2	39..417	CDD:270771	100/385 (26%)
		S_TKc	92..354	CDD:214567	83/285 (29%)
		SCP-1	412..1080	CDD:114219	62/257 (24%)
		HR1_ROCK2	505..571	CDD:212028	18/65 (28%)
		Rho_Binding	979..1046	CDD:286056
		PH_ROCK	1151..1257	CDD:269948
		C1	1261..1307	CDD:237996
Nek2	NP_572415.1	STKc_Nek2	18..281	CDD:270857	84/286 (29%)
Nek2	NP_572415.1	S_TKc	19..281	CDD:214567	83/285 (29%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910