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Protein Alignment EIF4E2 and eIF4E4

DIOPT Version :9

Sequence 1:	NP_004837.1	Gene:	EIF4E2 / 9470	HGNCID:	3293	Length:	245	Species:	Homo sapiens
Sequence 2:	NP_648052.1	Gene:	eIF4E4 / 38743	FlyBaseID:	FBgn0035709	Length:	229	Species:	Drosophila melanogaster

Alignment Length:	230	Identity:	77/230 - (33%)
Similarity:	125/230 - (54%)	Gaps:	26/230 - (11%)

- Green bases have known domain annotations that are detailed below.

Human     1 MNNKFDALKDDDSGDHDQNEENSTQKDGE--KEKTERDKNQSSSKRKAVVPGPAEHPLQYNYTFW 63
            |:|..:.|.|..|   ..:|:..|..|.:  |..||            :|....:|||:..:|.|
  Fly    12 MDNGTETLADSPS---SSSEDLKTLSDMDIRKPVTE------------IVDLRLKHPLENTWTLW 61

Human    64 YSRRTPGRPTSSQSYEQNIKQIGTFASVEQFWRFYSHMVRPGDLTGHSDFHLFKEGIKPMWEDDA 128
            |...     ..|:::|....:|.:|..||.||..|:|:.:|.::...||:.|||:||:|||||||
  Fly    62 YLEN-----DRSKNWEDMQNEITSFDMVEDFWSLYNHIKQPSEIRVGSDYSLFKKGIQPMWEDDA 121

Human   129 NKNGGKWIIRLRKGLAS---RCWENLILAMLGEQFMVGEEICGAVVSVRFQEDIISIWNKTASDQ 190
            ||.||:|:|.:.:|..:   :.|.:::|.::||.|...||:||||:::|.:.:.||||.....::
  Fly   122 NKFGGRWVINMGRGSKAELDKLWLDVLLILIGEAFENTEEVCGAVINLRGKSNKISIWTANGHNE 186

Human   191 ATTARIRDTLRRVLNLPPNTIMEYKTHTDSIKMPG 225
            .....|...||.:|.|||:. ::|:.|.|::...|
  Fly   187 LAVMEIGLKLRDLLVLPPHQ-LQYQLHKDTMCKQG 220

Known Domains:

Indicated by green bases in alignment.

Software error:

Illegal division by zero at /www/www.flyrnai.org/docroot/cgi-bin/DRSC_prot_align.pl line 591.

For help, please send mail to the webmaster (ritg@hms.harvard.edu), giving this error message and the time and date of the error.