DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment SIGLEC6 and wrk-1

DIOPT Version :9

Sequence 1:	XP_011525835.1	Gene:	SIGLEC6 / 946	HGNCID:	10875	Length:	464	Species:	Homo sapiens
Sequence 2:	NP_001024651.1	Gene:	wrk-1 / 181093	WormBaseID:	WBGene00006942	Length:	452	Species:	Caenorhabditis elegans

Alignment Length:	383	Identity:	87/383 - (22%)
Similarity:	137/383 - (35%)	Gaps:	98/383 - (25%)

- Green bases have known domain annotations that are detailed below.

Human    11 EMLPLLLPLLWAGALAQERR-----FQLEGPESLTVQ---EGLCVLVPCRLPTTLPA-------S 60
            :::.|:|.||.|...||.|.     ...|| ||||::   |...|.:..|..|.:.|       :
Worm     3 KLVLLILGLLIASTSAQIRTKGGTLIAKEG-ESLTLRCEVEDPSVAIIWRKNTEVVAVDDEILDT 66

Human    61 YYGYGYWFLEGADVPVATNDPDEEVQEETRGRFHLLWDPRRKNCSLSIRDARRRDNAAYFFRLKS 125
            |.||.. .:||: ..|.|....|.:            :....:|:|:      ....:..|.:|.
Worm    67 YGGYEI-SMEGS-TSVLTIKRVEPI------------NSANYSCALA------EPEVSVTFVIKV 111

Human   126 KWMKYGYTSSKLSVRVMALTHRPNISIPGTLESGHPSNLTCSVPWVCEQGTP-PIFSWMSAA--- 186
            :..|    .:::||:.:.:. .|:..:...........:||.|    ::|.| |...|...|
Worm   112 QVFK----PTQVSVKPLVVI-SPDTGVYHARVGEKNLVITCHV----KEGNPKPGVVWTKQAAKL 167

Human   187 PTSLGPRTTQSSVLTITPRPQDHSTNLTCQV-TFPGAGVTMERTIQLNVSWMLRRPPLSTPDAPQ 250
            |..: .|....:.:.||...:.|:....|.. ...|:.   ..||.::|:     .||
Worm   168 PEDI-KREHGGARIVITEVKKHHAGKYNCLAENIAGSD---RATIDIHVA-----EPL------- 216

Human   251 KVAISIFQGNSAAFKILQNTSS-LPVLEGQALRLLCDADGNPPAHLSW-FQGFPA-LNATPISNT 312
                   ||.......::|..: :||.:.|.....|..||.|...:.| |.|:.. .|......|
Worm   217 -------QGEREEKPWVKNEDTFIPVRKNQNASFWCTYDGTPVPQVEWLFNGYKINFNDEKFKKT 274

Human   313 GVLELPQ-----------VGSAEE---GDFTCRAQHPLGSLQISLSLFVHWKPEGRAG 356
            .  |..|           ||...|   ||:.||..:.||    |::..||  ..||.|
Worm   275 S--ETAQRLNGYSKSTLTVGDISEEAFGDYACRISNKLG----SVTAVVH--VSGRPG 324

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
SIGLEC6	XP_011525835.1	Ig	31..141	CDD:299845	26/119 (22%)
		IG_like	36..141	CDD:214653	24/114 (21%)
		Ig_3	147..218	CDD:290638	15/75 (20%)
		I-set	265..347	CDD:254352	25/98 (26%)
		Ig	277..347	CDD:299845	22/85 (26%)
wrk-1	NP_001024651.1	IG_like	25..113	CDD:214653	23/108 (21%)
		IGc2	31..96	CDD:197706	19/79 (24%)
		IG_like	132..212	CDD:214653	17/87 (20%)
		IGc2	142..202	CDD:197706	14/64 (22%)
		IG_like	235..320	CDD:214653	25/92 (27%)
		Ig	245..318	CDD:143165	21/78 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X34
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.000