DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment SIGLEC6 and LOC101884840

DIOPT Version :9

Sequence 1:	XP_011525835.1	Gene:	SIGLEC6 / 946	HGNCID:	10875	Length:	464	Species:	Homo sapiens
Sequence 2:	XP_021322151.1	Gene:	LOC101884840 / 101884840	-ID:	-	Length:	692	Species:	Danio rerio

Alignment Length:	303	Identity:	71/303 - (23%)
Similarity:	113/303 - (37%)	Gaps:	61/303 - (20%)

- Green bases have known domain annotations that are detailed below.

Human    36 PESLTVQEGLCVLVPCRLPTTLPASYYGYGYWFLEGADVPVATN--------DPDEEVQEETRGR 92
            || :|.....||::||.         :...:.:|.|..|....|        || .:|.:..:||
Zfish   333 PE-ITALPRSCVVIPCS---------FSVEHKYLTGLRVRWVNNNGGYMYHTDP-VDVLDNFKGR 386

Human    93 FHLLWDPRRKNCSLSIRDARRRDNAAYFFRLKSKWMKYGYTSSKLSVRVMALTHRPNI-SIPGTL 156
            ..||.:|..:||:|.:.|.|..||..:.|:.:.|..||.:.:|.:.:.:.|...:|.: |:|..:
Zfish   387 TRLLGNPDERNCTLEMDDVRTHDNGPFCFQAEKKEEKYSFNNSCVFIIMRASPDQPVMSSVPEDI 451

Human   157 ESGHPSNLTCSVPWVCEQGTPPIFSW--------MSAAPTSLGPRTTQSSVLTITPRPQDHSTNL 213
            |.|....:.|||...| ...||..:|        :|..|...|...|.|.:..| |...:....:
Zfish   452 EPGTAVTVKCSVKHTC-SSHPPKITWSVPTVRETISHNPMGGGVWETVSKMKFI-PTGYEEEDEI 514

Human   214 TCQVTFPGAGVTMERTIQLNVSWM--LRRPPLSTPDAPQKVAISIFQG----------------- 259
            .|...|.|.......:..|:|..:  :...|.....:...|.|.|..|
Zfish   515 ICSANFWGGKTQSNSSAPLSVKRIQAVESGPYIIASSLVFVLICILAGVFMYKRHQRQPCEDITR 579

Human   260 ---NSAAFKILQNTSSLPVLEGQALRL-------LCDADGNPP 292
               ..:.:....:..|:|  ||:|...       :.||.|.||
Zfish   580 SEQRRSVWNRFSSRFSMP--EGRAAWFNSGNRSDIRDAPGRPP 620

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
SIGLEC6	XP_011525835.1	Ig	31..141	CDD:299845	31/112 (28%)
		IG_like	36..141	CDD:214653	31/112 (28%)
		Ig_3	147..218	CDD:290638	20/79 (25%)
		I-set	265..347	CDD:254352	10/35 (29%)
		Ig	277..347	CDD:299845	8/23 (35%)
LOC101884840	XP_021322151.1	Ig	1..>83	CDD:325142
		Ig	226..307	CDD:325142
		Ig	335..426	CDD:325142	28/100 (28%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	74	1.000	Inparanoid score	I12412
NCBI	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR12035
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X34
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	4	4.060