DRSC/TRiP Functional Genomics Resources

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Protein Alignment HOMER1 and PRR1

DIOPT Version :10

Sequence 1:NP_004263.1 Gene:HOMER1 / 9456 HGNCID:17512 Length:354 Species:Homo sapiens
Sequence 2:NP_012806.1 Gene:PRR1 / 853744 SGDID:S000001599 Length:518 Species:Saccharomyces cerevisiae


Alignment Length:264 Identity:51/264 - (19%)
Similarity:93/264 - (35%) Gaps:81/264 - (30%)


- Green bases have known domain annotations that are detailed below.


Human    99 FAEKFQEFKEAARLAKEKSQEKMELTSTPSQESAGGDLQS-PLTPESINGTDDERTPDVTQNSEP 162
            |.:...:..|.| |..|..:|..::.||   |...||.:| ||| .||...::.:.........|
Yeast    21 FPDSIGDQHEKA-LIDENGEEDKKMAST---EGTTGDSRSTPLT-VSIPTFENVQALPTPMTYTP 80

Human   163 RAEPTQNALPFSHSSAISKHWEAELATLKGNNAKLTAALLESTANVKQWKQQLAAYQEEAERLH- 226
            .:....:..|...||            |.....:..|.||:...:|.|..|::.:.......|. 
Yeast    81 LSPGNLSMSPIDQSS------------LNIPKRRSHARLLDDMLSVTQPNQRVVSELIAPANLSP 133

Human   227 KRVTELECVSSQA---NAVHT-------HKTELNQTIQELEETL--------------------- 260
            :||..|..|:.:|   ::|.:       :..|.:.:.::.::.:                     
Yeast   134 QRVVSLPTVTEEALVNDSVDSDNYTKEPYFPESSSSTEKCDDDIFQGFLLDHWDRPLLWKKVRPI 198

Human   261 -------------------KLKEEEIERLK--QEIDNARE----------LQEQRDSLTQKLQEV 294
                               |||:..::|||  :|:.|..:          |....:|||::||.:
Yeast   199 GSGNFSTVLLYELMDQSNPKLKQVAVKRLKYPEELSNVEQINTSLRYKETLSRLENSLTRELQVL 263

Human   295 EIRN 298
            :..|
Yeast   264 KSLN 267

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
HOMER1NP_004263.1 EVH1_Homer_Vesl 3..111 CDD:269917 2/11 (18%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 114..173 14/59 (24%)
Smc <181..>352 CDD:440809 30/181 (17%)
Required for tetramerization. /evidence=ECO:0000250|UniProtKB:Q9Z214 290..354 3/9 (33%)
PRR1NP_012806.1 S_TKc 192..508 CDD:214567 15/76 (20%)

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