DRSC/TRiP Functional Genomics Resources

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Protein Alignment HOMER1 and homer1b

DIOPT Version :10

Sequence 1:NP_004263.1 Gene:HOMER1 / 9456 HGNCID:17512 Length:354 Species:Homo sapiens
Sequence 2:NP_001002496.3 Gene:homer1b / 436769 ZFINID:ZDB-GENE-040801-44 Length:398 Species:Danio rerio


Alignment Length:359 Identity:268/359 - (74%)
Similarity:306/359 - (85%) Gaps:8/359 - (2%)


- Green bases have known domain annotations that are detailed below.


Human     3 EQPIFSTRAHVFQIDPNTKKNWVPTSKHAVTVSYFYDSTRNVYRIISLDGSKAIINSTITPNMTF 67
            ||||:|||||||||||:|||||:||||||||||||||||||||||||||||||||||||||||:|
Zfish    41 EQPIYSTRAHVFQIDPSTKKNWMPTSKHAVTVSYFYDSTRNVYRIISLDGSKAIINSTITPNMSF 105

Human    68 TKTSQKFGQWADSRANTVYGLGFSSEHHLSKFAEKFQEFKEAARLAKEKSQEKMELTSTPSQESA 132
            |||||||||||||||||||||||||||||:|||:||.|:|||||:|||||.|||||.|:|||||.
Zfish   106 TKTSQKFGQWADSRANTVYGLGFSSEHHLAKFADKFAEYKEAARIAKEKSLEKMELASSPSQESP 170

Human   133 GGDLQSPLTPE------SINGTDDERT-PDVTQNSEPRAEPTQNALPFSHSSAISKHWEAELATL 190
             .|:.|||||.      .||||.|:.| .||:.||..:::.:......:||...:||||||||.|
Zfish   171 -ADIHSPLTPPVTADLCRINGTGDDVTLSDVSPNSMLQSDLSPTTPTLAHSPTTNKHWEAELAAL 234

Human   191 KGNNAKLTAALLESTANVKQWKQQLAAYQEEAERLHKRVTELECVSSQANAVHTHKTELNQTIQE 255
            |.|||||||||||||||||||||||||||||||||||||:|||..|||.|.:.:.||||||||:|
Zfish   235 KSNNAKLTAALLESTANVKQWKQQLAAYQEEAERLHKRVSELESQSSQTNVIKSQKTELNQTIEE 299

Human   256 LEETLKLKEEEIERLKQEIDNARELQEQRDSLTQKLQEVEIRNKDLEGQLSDLEQRLEKSQNEQE 320
            ||.||:.||||:.|||:|::||::||.|:|.||:||::.::|||:||.||||||||||.||.:||
Zfish   300 LECTLRAKEEEMMRLKEEVENAKQLQAQKDELTKKLEDTDMRNKELEEQLSDLEQRLESSQVDQE 364

Human   321 AFRNNLKTLLEILDGKIFELTELRDNLAKLLECS 354
            ..|.||||||||||||||||||||||||||:|.|
Zfish   365 NLRKNLKTLLEILDGKIFELTELRDNLAKLIEDS 398

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
HOMER1NP_004263.1 EVH1_Homer_Vesl 3..111 CDD:269917 99/107 (93%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 114..173 31/65 (48%)
Smc <181..>352 CDD:440809 131/170 (77%)
Required for tetramerization. /evidence=ECO:0000250|UniProtKB:Q9Z214 290..354 49/63 (78%)
homer1bNP_001002496.3 EVH1_Homer_Vesl 41..149 CDD:269917 99/107 (93%)
Smc <225..>397 CDD:440809 131/171 (77%)

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