Protein Alignment HOMER1 and homer

DIOPT Version :10

• Sequence 1: NP_004263.1
• Gene: HOMER1 / 9456
• HGNCID: 17512
• Length: 354
• Species: Homo sapiens
• Sequence 2: NP_001036341.2
• Gene: homer / 33944
• FlyBaseID: FBgn0025777
• Length: 531
• Species: Drosophila melanogaster
• Alignment Length: 416
• Identity: 158/416 - (37%)
• Similarity: 220/416 - (52%)
• Gaps: 90/416 - (21%)

Human     1 MGEQPIFSTRAHVFQIDPNTKKNWVPTSKHAVTVSYFYDSTRNVYRIISLDGSKAIINSTITPNM 65
            |||||||:.:||||.|||.||:.|:..|..||.||:||||:||:|||||::|:||:|||||||||
  Fly     1 MGEQPIFTCQAHVFHIDPKTKRTWITASMKAVNVSFFYDSSRNLYRIISVEGTKAVINSTITPNM 65

Human    66 TFTKTSQKFGQWADSRANTVYGLGFSSEHHLSKFAEKFQEFKEAARLAKEKSQEKMELTSTPSQE 130
            |||:||||||||:|.||||||||||:||..|:||.|||||.|||.:.|.:.:.....:|.|.|..
  Fly    66 TFTQTSQKFGQWSDVRANTVYGLGFASEAELTKFVEKFQEVKEATKNAMKSANGSNAVTPTTSAN 130

Human   131 S------AGGDLQSPLT--------PESINGTDDE------------RTPDVTQ---NSEPRAEP 166
            :      |.|.:|:..|        |.:::.|:.:            .|.||..   ::.|..:|
  Fly   131 TSPISGRAVGSMQNDNTAIDPHTVEPPNMSNTNTQNANPDSPSHKLLNTSDVKADIGSATPSPQP 195

Human   167 TQNA---------------------------------------LPFSHSSAISKHWEAELATLKG 192
            |...                                       :..:.|.|.:|.||.||||||.
  Fly   196 TSGVTGGGGVTISSGGSIVGMHTGPGAGATAEQQLKYENERLKMALAQSCANAKKWEIELATLKN 260

Human   193 NNAKLTAALLESTANVKQWKQQLAAYQEEAERLHKRVTELECVSSQANAV---HTHKTELNQTIQ 254
            ||.:||:||.||||||.:||:||..|:||..|| ||..|..||.....|.   ...:.||.:.:
  Fly   261 NNIRLTSALQESTANVDEWKRQLHTYKEENIRL-KRDMEQLCVGGGVVAAAGGGATEDELRREV- 323

Human   255 ELEETLKLKEEEIER--LKQEIDNARELQEQRDSLTQKLQEVEIRNKDLEGQLSDLEQRLEKSQN 317
               .|||.:.|::::  ::||:    ||:....||.:|      .|.....:||::.....|..:
  Fly   324 ---ATLKARTEQLQKELMQQEL----ELKSANISLREK------SNDQTLAKLSEVNGVFAKHLS 375

Human   318 EQEAFRNNLKTLLEILDGKIFELTEL 343
            |....:.::::|::|  .|.. .|||
  Fly   376 ELYGVQKDMESLIQI--AKCTXDTEL 399

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
HOMER1	NP_004263.1	EVH1_Homer_Vesl	3..111	CDD:269917	78/107 (73%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	114..173		15/126 (12%)
		Smc	<181..>352	CDD:440809	60/168 (36%)
		Required for tetramerization. /evidence=ECO:0000250|UniProtKB:Q9Z214	290..354		12/54 (22%)
homer	NP_001036341.2	EVH1_Homer_Vesl	3..111	CDD:269917	78/107 (73%)
		SMC_prok_B	<207..>389	CDD:274008	57/196 (29%)