Protein Alignment HOMER1 and myo2

DIOPT Version :9

• Sequence 1: NP_004263.1
• Gene: HOMER1 / 9456
• HGNCID: 17512
• Length: 354
• Species: Homo sapiens
• Sequence 2: NP_588114.1
• Gene: myo2 / 2539513
• PomBaseID: SPCC645.05c
• Length: 1526
• Species: Schizosaccharomyces pombe
• Alignment Length: 293
• Identity: 76/293 - (25%)
• Similarity: 138/293 - (47%)
• Gaps: 50/293 - (17%)

Human    92 SEHHLSKFAEKFQEFK-EAARLAKEKSQEKMELTSTPSQESAGGDLQSPLTPESINGTDDERTPD 155
            ::..|.|...:..|.| |..:....||:.:.:|..|.:..:|   :::.||.|.....|.|   :
pombe   822 NDKQLKKRDAEIIELKYELKKQQNSKSEVERDLVETNNSLTA---VENLLTTERAIALDKE---E 880

Human   156 VTQNSEPRAEPTQNALPFSHSSAISKHWEAELATLKGNNAKLTAALLESTANVK-------QWKQ 213
            :.:.::.|....:::  ||.:...:::.:.|.|:||..|.:|.:.|||.|:.|:       :.|:
pombe   881 ILRRTQERLANIEDS--FSETKQQNENLQRESASLKQINNELESELLEKTSKVETLLSEQNELKE 943

Human   214 QLAAYQEEAERLHKRVTELECVSSQANAVHTHKTELNQTIQELEETLKLKEEEIERLKQEI-DNA 277
            :|:.  ||.:.|..: .|||.:......|.:.|.|.|:..:.|:||:..|:.|:::|.:.| |..
pombe   944 KLSL--EEKDLLDTK-GELESLRENNATVLSEKAEFNEQCKSLQETIVTKDAELDKLTKYISDYK 1005

Human   278 RELQEQRDSLT-QKLQEVEIRNKDLEGQLSDLEQRLEKSQNE----------------------- 318
            .|:||.|  || ||:.|..|:.   ||.||:..:|::|.:.|
pombe  1006 TEIQEMR--LTNQKMNEKSIQQ---EGSLSESLKRVKKLERENSTLISDVSILKQQKEELSVLKG 1065

Human   319 -QEAFRNNLKTLLEILDGKIFELTELRDNLAKL 350
             ||...|||:..:..|:..:.:|.:|:..|..|
pombe  1066 VQELTINNLEEKVNYLEADVKQLPKLKKELESL 1098

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
HOMER1	NP_004263.1	EVH1_Homer_Vesl	3..111	CDD:269917	5/19 (26%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	114..173		11/58 (19%)
		SMC_N	<157..>352	CDD:330553	61/227 (27%)
		Required for tetramerization. /evidence=ECO:0000250|UniProtKB:Q9Z214	290..354		20/85 (24%)
myo2	NP_588114.1	COG5022	6..1516	CDD:227355	76/293 (26%)
		Myosin_N	25..>48	CDD:280832
		MYSc_class_II	91..743	CDD:276951

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910