Protein Alignment HOMER2 and K02E10.7

DIOPT Version :10

• Sequence 1: XP_006720838.1
• Gene: HOMER2 / 9455
• HGNCID: 17513
• Length: 364
• Species: Homo sapiens
• Sequence 2: NP_001360081.1
• Gene: K02E10.7 / 186892
• WormBaseID: WBGene00019321
• Length: 609
• Species: Caenorhabditis elegans
• Alignment Length: 456
• Identity: 84/456 - (18%)
• Similarity: 143/456 - (31%)
• Gaps: 147/456 - (32%)

Human    23 VFQIDPNTKKNWMPASKQAVTVSYFYDVTRNSYRIISVDGAKVIINSTITPNM--TFTKTSQKFG 85
            :..|:.:...||:|.|:..:.:..|                       |.|.:  ..::.:.:..
 Worm   187 ISDIESSQFLNWLPFSQTPLHILPF-----------------------IAPELHNQLSEVTSECD 228

Human    86 QWADSRANTVFGLG---FSSEQQLTKFAEKFQEVKEAAKIAKDKTQEKIETSSNHSQESGRETPS 147
            .|:......|...|   |..|.:.|........:..:..:|.||.|..:| ...|...|.|.:..
 Worm   229 LWSLGVCIFVMATGSCPFILESRNTMMESIQAGILGSPVLASDKIQSLVE-QLIHVNPSERMSLK 292

Human   148 STQASSVNGTDDEKASHAGPANTHLKSENDKLK-----------IALTQSAANVKKWEIELQTLR 201
            |.       .:|:..:.....|..:....|.::           .:|.:|.......||.::||.
 Worm   293 SL-------IEDDWMTSDLVWNYFISCHEDLIRELPVVDRFIPAESLEKSTVQRDGSEISIETLD 350

Human   202 ESNARLTT-ALQESAASVEQ----------WKRQFSICRDENDRLR--NKIDELEE-------QC 246
            |....:.: ..:|.|.|.||          :.::|::...||.|..  |.|..:|:       .|
 Worm   351 EGYKSVASDHPEEPAVSGEQQVLTEPVPKKYHKKFAVFAMENVRKEWDNDITRIEKCKLRDGSMC 415

Human   247 --------SEINREKEKNTQLKRRIEELEAELREKETELKD-----------LRKQSEI-----I 287
                    .||......|..:|.|:.:.....|..:..:.|           .|:.:||     :
 Worm   416 LRIVIPAKDEIASSSIFNRIIKSRLGQTIKRFRSHQDTVVDSDFGDYALMNFRRENTEIEVARNM 480

Human   288 PQLMSECE---YVSEKLEAAERDNQNLEDKV----RSLKTDI-------------------EESK 326
            |:..::.:   |..:|  .|||..:||..|:    |...||.                   ||..
 Worm   481 PKFTNKQQVQLYYCKK--EAERVWENLAIKICMRCRRAGTDALNHDEDKCLYKLIAEAVESEEVI 543

Human   327 YRQRHLKVELKSFLEVL---DGKIDDLHDFRR-------------------------GLSKLGTD 363
            |.....:..|:.|..|.   .|:...:..|||                         |.|.||:|
 Worm   544 YYGAEDQFNLRFFSLVYRNDGGRASAMTRFRRGSIRVLTSGYRRIVKRFRRQSTSGSGSSGLGSD 608

Human   364 N 364
            |
 Worm   609 N 609

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
HOMER2	XP_006720838.1	EVH1_Homer_Vesl	13..121	CDD:269917	14/102 (14%)
		SMC_prok_B	<103..343	CDD:274008	61/320 (19%)
K02E10.7	NP_001360081.1	Protein Kinases, catalytic domain	52..300	CDD:473864	24/143 (17%)