DRSC/TRiP Functional Genomics Resources

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Protein Alignment HOMER2 and epi-1

DIOPT Version :10

Sequence 1:XP_006720838.1 Gene:HOMER2 / 9455 HGNCID:17513 Length:364 Species:Homo sapiens
Sequence 2:NP_001294008.1 Gene:epi-1 / 177956 WormBaseID:WBGene00001328 Length:3715 Species:Caenorhabditis elegans


Alignment Length:322 Identity:66/322 - (20%)
Similarity:137/322 - (42%) Gaps:79/322 - (24%)


- Green bases have known domain annotations that are detailed below.


Human    88 ADSRANTVFGLGFSSEQQLTKFAEKFQEVKEAAKIAKD--------------------KTQEKIE 132
            |:..:.|:.|      .:|.:..::|.::.|..|:..|                    :.|.|:.
 Worm  2169 ANISSATIVG------ARLARNKKEFNDINEITKMLNDEENSFGNVFGDAQDILTNSTQIQNKLV 2227

Human   133 TSSNHSQESGRETPSSTQASSVNGTD--DEKASHAGPANTHLKSEND-KLKIALTQSAANVKKWE 194
            .:..|||.|    .||.:..::|||:  .|....|..|...::|..: .|.|..:..|.||    
 Worm  2228 RTKTHSQNS----VSSAKNITLNGTEFLQEVMKRAQRARQSVRSLAEIALAIGSSSKAVNV---- 2284

Human   195 IELQTLRESNARLTTALQESAASVEQWKRQFSICRDENDRLRNKIDELEEQCSEINREKEKNTQL 259
             :.:.|:|:...|.|.   .|||.:|:..:......:.:.::.||   :|:..:::::||.....
 Worm  2285 -DPRLLKEAEETLMTL---EAASADQYPEKAQTVPGKLEEIQKKI---QEETEKLDKQKETFEAQ 2342

Human   260 KRRIEELEAELREKETELKDLRKQSE------------IIPQLMSECEYVSEKLEAAERD----- 307
            |:|.|||.|.|...:..||:.:.:::            .:..|::......|::|||:.:     
 Worm  2343 KKRAEELAAYLNSAQQLLKESKSKADKSNNIAKMLQLTKVENLVAAITDDLERVEAAKGEFQKLN 2407

Human   308 ------NQNLEDK----------VRSLKTDIEES-KYRQRHLKVELKSF-LEVLDGKIDDLH 351
                  .:||:||          :...:.|:.|: :..::.::.:.||. :::::.|..:||
 Worm  2408 VAIGNITENLKDKREEMTHAVTTLNETRNDVAEALEAAKKRVRRDEKSVDMQLVNAKAHELH 2469

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
HOMER2XP_006720838.1 EVH1_Homer_Vesl 13..121 CDD:269917 6/32 (19%)
SMC_prok_B <103..343 CDD:274008 60/297 (20%)
epi-1NP_001294008.1 LamNT 24..296 CDD:214532
EGF_Lam 297..345 CDD:238012
Laminin_EGF 427..474 CDD:395007
EGF_Lam 471..520 CDD:238012
EGF_Lam 519..564 CDD:214543
Laminin_EGF 564..612 CDD:395007
Laminin_EGF 610..658 CDD:395007
Laminin_EGF 656..703 CDD:395007
Laminin_EGF 701..753 CDD:395007
Laminin_EGF 756..806 CDD:395007
EGF_Lam 808..854 CDD:238012
CBM6-CBM35-CBM36_like 855..988 CDD:271143
Laminin_EGF 1426..1474 CDD:395007
EGF_Lam 1472..1515 CDD:238012
Laminin_EGF 1517..1567 CDD:395007
Laminin_EGF 1565..1613 CDD:395007
LamB 1669..1793 CDD:214597
EGF_Lam 1840..1883 CDD:238012
Laminin_EGF 1891..1945 CDD:395007
EGF_Lam 1947..1998 CDD:238012
EGF_Lam 2001..2045 CDD:214543
EGF_Lam 2048..2092 CDD:214543
EGF_Lam 2095..2140 CDD:214543
PTZ00121 <2289..2917 CDD:173412 38/187 (20%)
Laminin_II 2589..2730 CDD:368703
LamG 2704..2875 CDD:238058
LamG 2909..3057 CDD:238058
LamG 3353..3510 CDD:238058
LamG 3532..3682 CDD:238058
Blue background indicates that the domain is not in the aligned region.

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