DRSC/TRiP Functional Genomics Resources

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Protein Alignment HOMER3 and homer3

DIOPT Version :9

Sequence 1:NP_001139194.1 Gene:HOMER3 / 9454 HGNCID:17514 Length:361 Species:Homo sapiens
Sequence 2:NP_001164991.1 Gene:homer3 / 779484 XenbaseID:XB-GENE-962123 Length:357 Species:Xenopus tropicalis


Alignment Length:358 Identity:234/358 - (65%)
Similarity:290/358 - (81%) Gaps:5/358 - (1%)


- Green bases have known domain annotations that are detailed below.


Human     2 STAREQPIFSTRAHVFQIDPATKRNWIPAGKHALTVSYFYDATRNVYRIISIGGAKAIINSTVTP 66
            :|.|||||||||||||||||.||:||:||.|||:|||||||||||||||||:||.|||||||:||
 Frog     4 TTNREQPIFSTRAHVFQIDPITKKNWLPASKHAVTVSYFYDATRNVYRIISVGGTKAIINSTITP 68

Human    67 NMTFTKTSQKFGQWADSRANTVYGLGFASEQHLTQFAEKFQEVKEAARLAREKSQDGGELTSPAL 131
            |||||||||||||||||||||||||||||||:|:|||||||||:||||||||:|||..:||:|||
 Frog    69 NMTFTKTSQKFGQWADSRANTVYGLGFASEQNLSQFAEKFQEVREAARLARERSQDKTDLTNPAL 133

Human   132 GLASHQVPPSPLVSANGPGEEKLFRSQSADAPGPTERERLKKMLSEGSVGEVQWEAEFFALQDSN 196
            .:.|.||.|||::||||||::||||||||:....|||||:|||||||||.|||||||||:|||:|
 Frog   134 NITSQQVLPSPIISANGPGDDKLFRSQSAEMELSTERERVKKMLSEGSVCEVQWEAEFFSLQDNN 198

Human   197 NKLAGALREANAAAAQWRQQLEAQRAEAERLRQRVAELEAQAASEVTPTGEKEGLGQGQSLEQLE 261
            |||..||||:||...:|::||.|.:.|||.|||||||||:|...|   |.|:.|......|:.||
 Frog   199 NKLVAALRESNANVEKWKKQLAAYQEEAETLRQRVAELESQTLKE---TNEEPGDELALRLKDLE 260

Human   262 ALVQTKDQEIQTLKSQTGGPREALEAAEREETQQKVQDLETRNAELEHQLRAMERSLEEARAERE 326
            .|::||::||..||.|.....| || :||::..|::|:||.||.|:|.:|...|:||.::::||:
 Frog   261 TLLKTKEEEILLLKEQRPDLME-LE-SERDKLLQRLQELEERNQEMEKELERSEQSLRDSQSERD 323

Human   327 RARAEVGRAAQLLDVSLFELSELREGLARLAEA 359
            |.|.|:.:|.:.|||.:.:|:|||.||::|.|:
 Frog   324 RVREEISKAGEDLDVKICQLNELRIGLSKLLES 356

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
HOMER3NP_001139194.1 Required for interaction with NFATC2. /evidence=ECO:0000269|PubMed:18218901 1..80 67/77 (87%)
EVH1_Homer_Vesl 6..114 CDD:269917 96/107 (90%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 114..169 35/54 (65%)
homer3NP_001164991.1 EVH1_Homer_Vesl 8..116 CDD:269917 96/107 (90%)
SMC_N <153..>347 CDD:330553 104/198 (53%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 254 1.000 Domainoid score I11633
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 1 1.000 - - H37972
Inparanoid 1 1.050 441 1.000 Inparanoid score I8514
NCBI 1 1.000 - -
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D1251658at2759
OrthoFinder 1 1.000 - - FOG0011226
OrthoInspector 1 1.000 - - oto157140
Panther 1 1.100 - - LDO PTHR10918
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 1 1.000 - - X1808
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
99.160

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