Protein Alignment GGPS1 and Pdss2

DIOPT Version :10

• Sequence 1: NP_004828.1
• Gene: GGPS1 / 9453
• HGNCID: 4249
• Length: 300
• Species: Homo sapiens
• Sequence 2: NP_649277.1
• Gene: Pdss2 / 40323
• FlyBaseID: FBgn0037044
• Length: 448
• Species: Drosophila melanogaster
• Alignment Length: 305
• Identity: 64/305 - (20%)
• Similarity: 104/305 - (34%)
• Gaps: 84/305 - (27%)

Human    12 LLEPYKYLLQLPGKQ-------VRTKLSQAFNHWLKVP---EDK-------LQIIIEVTEML--- 56
            |::..|:|| ..||.       :...:|:|..|...||   :||       .:.:.|||||:
  Fly   112 LMKTAKHLL-YNGKNTMQAWGLIVLLVSKAAGHAPSVPDVEQDKSAGVLHSQRALAEVTEMIRIS 175

Human    57 ---HNASLLI-------------DDIEDNSK---LRRGFPVAHS------------IYGIPSVIN 90
               ||:.:.:             ||:...:|   |...:.:.||            :..|.|.:.
  Fly   176 HLVHNSVVNLQSSTQAGQDVDTYDDMSFGNKIGLLTGDYLLGHSSAELANLRNQEVVELISSAVR 240

Human    91 SANYVYFLGLEKVLTLDHPDAVKLFTRQLLELHQGQGLDIYWRDNYT-CP-------TEEEYKAM 147
            ..:...|:|.........|.....|.|..|.:    |:|....|..| .|       .|||::..
  Fly   241 DFSESEFIGERDEQNNPLPYKPGTFQRPSLSV----GVDFNEHDVMTPMPIAQVLGNPEEEWECR 301

Human   148 VLQKTGGLFGLAVGLMQLFSDYKEDLKPLLNTLG----LFFQIRDDYANLHSKEYSENKSFCE-- 206
            .:...|.|.|.:.......:...|:|:......|    |.:|     |.|.::.:.     |.
  Fly   302 NILNAGSLLGKSCQASLKLAGQSEELQRHAYRFGKHLALAWQ-----ACLDAEPFQ-----CPQL 356

Human   207 --DLTEGKFSFPTIHAIWSRPESTQVQNILRQRTENIDIKKYCVH 249
              |:|....|.|.:..:...|.........:|..:|||..|  :|
  Fly   357 PLDVTFSLVSAPVLFHLEHDPGMYSQLEAGKQSVDNIDYDK--IH 399

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
GGPS1	NP_004828.1	polyprenyl_synt	9..250	CDD:459773	64/305 (21%)
Pdss2	NP_649277.1	Isoprenoid_Biosyn_C1	86..441	CDD:469660	64/305 (21%)