Protein Alignment GGPS1 and Fpps

DIOPT Version :10

• Sequence 1: NP_004828.1
• Gene: GGPS1 / 9453
• HGNCID: 4249
• Length: 300
• Species: Homo sapiens
• Sequence 2: NP_477380.1
• Gene: Fpps / 36209
• FlyBaseID: FBgn0025373
• Length: 419
• Species: Drosophila melanogaster
• Alignment Length: 295
• Identity: 77/295 - (26%)
• Similarity: 122/295 - (41%)
• Gaps: 86/295 - (29%)

Human    54 EMLHNASLLIDDIEDNSKLRRGFPVAHSIYGIP-SVINSA----NYVYFLGLEKVLTLDHPDAVK 113
            |||.:..::.||:.|||..|||.|..|.:..:. :.||.|    |.:|.: |:|  ...|.|...
  Fly   162 EMLQSFFIISDDVMDNSTTRRGQPCWHKVENVGLTAINDALMIENAMYAI-LKK--HFSHLDCYV 223

Human   114 LFTRQLLEL-HQ-------GQGLDIYWRDNYTCPTE---EEYKAMVLQKTGGL-----FGLAVGL 162
                .|:|| |:       ||.||  ..::..|.:|   |.|||:|..||...     |.||:.|
  Fly   224 ----ALMELFHEITYITTCGQSLD--QLNSNRCVSEFTMENYKAIVENKTAYYSFYLPFALALHL 282

Human   163 MQLFSDYKE-----DLKPLLNTLGLFFQIRDDYANLHSKEYSENKSFCEDLTEGKFSFPTIHAIW 222
                :.||:     ..|.:|..:|.|||::||:.:.........| ...|:.:.|.|:..:.|:
  Fly   283 ----AGYKDAEAFRQSKTILLEMGNFFQVQDDFLDCFGNPEVTGK-IGTDIQDNKCSWLAVVAM- 341

Human   223 SRPESTQVQNILRQRTENIDIKKYCV--HYLEDVGSFEYTRNTLKEL---------EAKAYKQI- 275
                         ||. |::.|:..|  :..|:....|..:...|||         |.::|..|
  Fly   342 -------------QRA-NVEQKQIMVDCYGKEEPAKVERVKELYKELGLPSTYAIFEEESYNMIK 392

Human   276 -----DARGGNPELVALVKH------LSKMFKEEN 299
                 .:||        |.|      |:|:::.::
  Fly   393 THIQQTSRG--------VPHQTFLQILNKIYQRDS 419

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
GGPS1	NP_004828.1	polyprenyl_synt	9..250	CDD:459773	63/223 (28%)
Fpps	NP_477380.1	polyprenyl_synt	112..373	CDD:459773	65/239 (27%)