DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CD33 and hbs

DIOPT Version :9

Sequence 1:	XP_011525833.1	Gene:	CD33 / 945	HGNCID:	1659	Length:	418	Species:	Homo sapiens
Sequence 2:	NP_001286439.1	Gene:	hbs / 44129	FlyBaseID:	FBgn0029082	Length:	1235	Species:	Drosophila melanogaster

Alignment Length:	300	Identity:	64/300 - (21%)
Similarity:	97/300 - (32%)	Gaps:	79/300 - (26%)

- Green bases have known domain annotations that are detailed below.

Human    75 FWLQVQESVTVQEGLCVLV---------------PCTFFHPIPYYDKNSPVHGYWFREGAIISRD 124
            ||:.:..:|.:...:|.::               |...||..|        |.....||......
  Fly     3 FWITLTFAVHLATTICHVMAAVTAPTPAAQVAAPPVQKFHLTP--------HDLQILEGTDTLLR 59

Human   125 SPVATNKLDQEVQEETQG-------------RFRLLGDPSRNNCSLSIVDARRRDNGSYFFRME- 175
            ..|:...  .:||....|             |:.:|.|..:|..:|.|.:|...|:..|..::.
  Fly    60 CEVSNRA--GKVQWTKDGFALGFSAVIPGFPRYSVLVDAKQNAYNLQIKNATLEDDAEYQCQVGP 122

Human   176 -------RGSTKYSYKSPQLSVHVTDLTHRPKILIPGTLEPGHSKNLT-----------CSVSWA 222
                   |.:.|.|..:...|:.:.......::      |....:|||           ..:.|.
  Fly   123 AAGNPAIRANAKLSIVAAPSSIVIEGYARNARV------EVEERQNLTLHCIAENANPAAEIVWF 181

Human   223 CEQG-----TPPIFSWLSAAPTSLGPRTTHSSVLIITPRPQDHGTNLTCQV--KFAGAGVTTERT 280
              ||     |.||.:....||    .|.|.||.|.:.||.:|.....:|:.  |.....|.....
  Fly   182 --QGEVPVSTAPIVTVNQTAP----KRFTTSSTLHLQPRAEDDYKEFSCEARHKALPPDVPMRAQ 240

Human   281 IQLNVTYVPQNPTTGIFPGDGSGKQETRAGVVHGAIGGAG 320
            :||:|.|.|..|   .|.|...|:...|...|..|....|
  Fly   241 VQLSVLYPPGAP---FFEGYSQGETLHRGQEVQIACRSRG 277

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CD33	XP_011525833.1	Ig	77..193	CDD:299845	26/151 (17%)
		IG_like	80..182	CDD:214653	24/137 (18%)
		ig	200..281	CDD:278476	23/98 (23%)
hbs	NP_001286439.1	Ig	44..122	CDD:299845	17/87 (20%)
		IG_like	45..137	CDD:214653	19/101 (19%)
		Ig	153..231	CDD:299845	22/89 (25%)
		IG_like	258..342	CDD:214653	4/19 (21%)
		Ig	266..327	CDD:299845	2/11 (18%)
		IG_like	357..>414	CDD:214653
		Ig	360..427	CDD:299845
		Ig	<468..526	CDD:299845
		I-set	547..633	CDD:254352
		Ig	556..631	CDD:299845
		I-set	644..735	CDD:254352
		IGc2	668..725	CDD:197706
		IG_like	751..829	CDD:214653
		IGc2	753..815	CDD:197706
		Ig	852..928	CDD:143165
		FN3	935..1017	CDD:238020
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910