DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CD33 and igcm-4

DIOPT Version :9

Sequence 1:	XP_011525833.1	Gene:	CD33 / 945	HGNCID:	1659	Length:	418	Species:	Homo sapiens
Sequence 2:	NP_508377.1	Gene:	igcm-4 / 180518	WormBaseID:	WBGene00022418	Length:	541	Species:	Caenorhabditis elegans

Alignment Length:	175	Identity:	36/175 - (20%)
Similarity:	56/175 - (32%)	Gaps:	44/175 - (25%)

- Green bases have known domain annotations that are detailed below.

Human   127 VATNKLDQEVQEETQG-------RFRLLGDPSRNNCSLSIVDARRRDNGSYFFRMERGSTKYSYK 184
            :||.|....:|....|       :::|    |:::..|.:...:..|:|.|..:...|   :.:|
Worm    59 IATEKDSTMIQWSKNGEQLDWDSQYKL----SKDSKELKMKSVKFEDSGRYQCQATNG---FGHK 116

Human   185 SPQLSVHVTD----------------LTHRPKILI--------PGTLEPGHSKNLTCSVSWACEQ 225
            :.:..|||.|                .|..|..||        |..:..|....|.|..     |
Worm   117 TIEFIVHVHDQHDKENSVKDYLVLSNTTASPSWLIDMNSEWRSPIKINTGGKLELRCPA-----Q 176

Human   226 GTP-PIFSWLSAAPTSLGPRTTHSSVLIITPRPQDHGTNLTCQVK 269
            |.| |...|.............|.|.:.:.|....|.....|.|:
Worm   177 GNPLPEIRWYQNEMEISEKTHKHVSTITVEPVESSHSGVYRCVVE 221

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CD33	XP_011525833.1	Ig	77..193	CDD:299845	15/72 (21%)
		IG_like	80..182	CDD:214653	12/61 (20%)
		ig	200..281	CDD:278476	17/79 (22%)
igcm-4	NP_508377.1	IGc2	52..114	CDD:197706	12/61 (20%)
		I-set	159..235	CDD:254352	15/68 (22%)
		IGc2	166..225	CDD:197706	14/61 (23%)
		IG_like	261..373	CDD:214653
		Ig	269..374	CDD:299845
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910