DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CD33 and meis1

DIOPT Version :9

Sequence 1:	XP_011525833.1	Gene:	CD33 / 945	HGNCID:	1659	Length:	418	Species:	Homo sapiens
Sequence 2:	XP_002931792.1	Gene:	meis1 / 100488182	XenbaseID:	XB-GENE-479439	Length:	465	Species:	Xenopus tropicalis

Alignment Length:	157	Identity:	31/157 - (19%)
Similarity:	50/157 - (31%)	Gaps:	45/157 - (28%)

- Green bases have known domain annotations that are detailed below.

Human    99 HPIPYYDKNSPVH----------GYWFREGAIISRDSPVATNKLDQEVQEETQGR-FRLLGDPSR 152
            ||.|..::...:.          ..||     |:....:....:||..:..:||. :...|.|..
Frog   297 HPYPSEEQKKQLAQDTGLTILQVNNWF-----INARRRIVQPMIDQSNRAVSQGTPYNADGQPMG 356

Human   153 NNCSLSIVDARRRDN----------GSYF-----FRMERGSTKYSYKSPQLSVHVTDLTHRPKIL 202
            .    .::|.::...          |||.     ..|..|..  ||.:.|:.:|...|.|...:
Frog   357 G----FVMDGQQHMGIRAPGLQGMPGSYISPSGPMGMSMGQP--SYTTSQMPLHHAQLRHGTSV- 414

Human   203 IPGTLEPGHSKNLTCSVSWACEQGTPP 229
              .|..|||..:....:     .|.||
Frog   415 --HTYIPGHHHHPAMMM-----HGGPP 434

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CD33	XP_011525833.1	Ig	77..193	CDD:299845	22/119 (18%)
		IG_like	80..182	CDD:214653	18/108 (17%)
		ig	200..281	CDD:278476	7/30 (23%)
meis1	XP_002931792.1	Meis_PKNOX_N	108..192	CDD:374576
meis1	XP_002931792.1	Homeobox_KN	290..329	CDD:368670	6/36 (17%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	73	1.000	Domainoid score	I35468
eggNOG	1	0.900	-	-		E1_2CYFK
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
NCBI	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm54708
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X34
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	6	5.860