Protein Alignment MAP4K4 and SSK22

DIOPT Version :10

• Sequence 1: NP_001381931.1
• Gene: MAP4K4 / 9448
• HGNCID: 6866
• Length: 1384
• Species: Homo sapiens
• Sequence 2: NP_009998.2
• Gene: SSK22 / 850436
• SGDID: S000000669
• Length: 1331
• Species: Saccharomyces cerevisiae
• Alignment Length: 370
• Identity: 100/370 - (27%)
• Similarity: 174/370 - (47%)
• Gaps: 91/370 - (24%)

Human     2 ANDSPAKSLVDIDLSSLRDPAGIFELVEVVGNGTYGQVYKGRHVKTGQLAA---IKVMDVTEDEE 63
            |.|...|.|:.: .|||.:.:..::....:|.||:||||...:::.|::.|   ||:.|.|..::
Yeast  1012 ATDQGNKYLLSL-ASSLSNVSMRWQKRSFIGGGTFGQVYSAINLENGEILAVKEIKIHDTTTMKK 1075

Human    64 --EEIKLEINMLKKYSHHRNIATYYGAFIKKSPPGHDDQLWLVMEFCGAGSITDLVKNTKGNTLK 126
              ..||.|:.:|:.. :|.||..|||..:      |.|::.:.||:|..||:..|:.:.:   ::
Yeast  1076 IFPLIKEEMTVLEML-NHPNIVQYYGVEV------HRDKVNIFMEYCEGGSLASLLDHGR---IE 1130

Human   127 EDWIAYI-SREILRGLAHLHIHHVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDRT-VGRR---- 185
            ::.:..: :.|:|.|||:||...|:|||||.:|:||..|..:|.||||.:    || ||.|
Yeast  1131 DEMVTQVYTFELLEGLAYLHQSGVVHRDIKPENILLDFNGIIKYVDFGTA----RTVVGSRTRTV 1191

Human   186 ---------------NTFIGTPYWMAPEVIA---------CDENPDATYDYRSDLWSCGITAIEM 226
                           |..:|||.:||||.|:         .|           |:|:.|...:||
Yeast  1192 RNAAVQDFGVETKSLNEMMGTPMYMAPETISGSAVKGKLGAD-----------DVWALGCVVLEM 1245

Human   227 AEGAPPLCDM-HPMRALFLIPRNPPPRLKSK-KWSKKFFSFIEGCLVKNYMQRPSTEQLLKHPFI 289
            |.|..|..:: :....::.:.....|:|.:: :.:....:|:|.|||::...|.:..:||..|::
Yeast  1246 ATGRRPWSNLDNEWAIMYHVAAGRIPQLPNRDEMTAAGRAFLERCLVQDPTMRATAVELLIDPWM 1310

Human   290 RDQPNERQVRIQLKDHIDRTRKKRGEKDETEYEYSGSEEEEEEVP 334
                      ||::                  |.:....|:::||
Yeast  1311 ----------IQIR------------------EIAFGNSEKDQVP 1327

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
MAP4K4	NP_001381931.1	Protein Kinases, catalytic domain	8..289	CDD:473864	92/317 (29%)
		CNH	1066..1364	CDD:214481
SSK22	NP_009998.2	STKc_MEKK4	1033..1309	CDD:270796	86/300 (29%)