Protein Alignment MAP4K4 and hpo

DIOPT Version :9

• Sequence 1: NP_001381931.1
• Gene: MAP4K4 / 9448
• HGNCID: 6866
• Length: 1384
• Species: Homo sapiens
• Sequence 2: NP_001261092.1
• Gene: hpo / 37247
• FlyBaseID: FBgn0261456
• Length: 669
• Species: Drosophila melanogaster
• Alignment Length: 594
• Identity: 176/594 - (29%)
• Similarity: 282/594 - (47%)
• Gaps: 95/594 - (15%)

Human    16 SSLRDPAGIFELVEVVGNGTYGQVYKGRHVKTGQLAAIKVMDVTEDEEEEIKLEINMLKK----Y 76
            |.|:.|..:|:::..:|.|:||.|||..|.::..:.|||::.|..|..|.|| ||:::::    |
  Fly    33 SLLQPPEKVFDIMYKLGEGSYGSVYKAVHKESSSIVAIKLVPVESDLHEIIK-EISIMQQCDSPY 96

Human    77 SHHRNIATYYGAFIKKSPPGHDDQLWLVMEFCGAGSITDLVKNTKGNTLKEDWIAYISREILRGL 141
                 :..|||::.|:    :|  ||:.||:|||||::|:::..| .||.||.||.|..:.|:||
  Fly    97 -----VVRYYGSYFKQ----YD--LWICMEYCGAGSVSDIMRLRK-KTLTEDEIATILSDTLQGL 149

Human   142 AHLHIHHVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDRTVGRRNTFIGTPYWMAPEVIACDENP 206
            .:||:...||||||..|:||......||.||||:.||..|:.:|||.||||:|||||||     .
  Fly   150 VYLHLRRKIHRDIKAANILLNTEGYAKLADFGVAGQLTDTMAKRNTVIGTPFWMAPEVI-----E 209

Human   207 DATYDYRSDLWSCGITAIEMAEGAPPLCDMHPMRALFLIPRNPPPRLKS-KKWSKKFFSFIEGCL 270
            :..||..:|:||.||||:|||||.||..::|||||:|:||:.|||..:. .:||.:|..|:..||
  Fly   210 EIGYDCVADIWSLGITALEMAEGKPPYGEIHPMRAIFMIPQKPPPSFREPDRWSTEFIDFVSKCL 274

Human   271 VKNYMQRPSTEQLLKHPFIRDQPNERQVRIQLKDHIDRTRKKRGEKDETEYEYSG--------SE 327
            ||....|.:..:||:|.|||:..:    |..||..::.|...| |:......:.|        |.
  Fly   275 VKEPDDRATATELLEHEFIRNAKH----RSILKPMLEETCAIR-EQQRANRSFGGVLAASQAKSL 334

Human   328 EEEEEVPEQEGEPSSIVNVPGESTLRRDFLRLQQENKERSEALRRQQ------LLQEQQLREQEE 386
            ..:|...:|....::.:..|| :.:...|...||.:...:..:...:      .|....||...:
  Fly   335 ATQENGMQQHITDNAFMEDPG-TLVPEKFGEYQQSSASDATMIAHAEQGVDEGTLGPGGLRNLSK 398

Human   387 YKRQLLA------------ERQKRIEQQKEQRRRLEEQQRREREARRQQEREQRRREQEEKRRLE 439
            ......|            :....:|.:......:......:....:..: :|:.|.:...:.||
  Fly   399 AAAPAAASSAASPLDMPAVDSGTMVELESNLGTMVINSDSDDSTTAKNND-DQKPRNRYRPQFLE 462

Human   440 ELERRRKEEEERRRAEEEKRRVEREQEYIRRQLEEEQRHLEVLQQQLLQEQAML----------- 493
            ..:|:...:   .|.:|:....    ||.....|::|:..:..|||...||.:.
  Fly   463 HFDRKNAGD---GRGDEKPIAT----EYSPAAAEQQQQQQQQQQQQQQDEQHLASGANDLNNWEH 520

Human   494 -LECRWREMEEHRQAERLQRQLQQEQAYLLSLQHD-----HRRPH-------PQHSQ-------- 537
             :|.:::::....|....|.|.||:......|.::     :.:|:       |...|
  Fly   521 NMEMQFQQISAINQYGLQQHQQQQQVLMAYPLMNEQLIALNNQPNLLLSNAAPMGQQGIPAAAPA 585

Human   538 QPPPPQQER 546
            ||||..|.:
  Fly   586 QPPPAYQNQ 594

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
MAP4K4	NP_001381931.1	None
hpo	NP_001261092.1	STKc_MST1_2	38..293	CDD:132943	120/272 (44%)
		S_TKc	42..293	CDD:214567	119/268 (44%)
		Mst1_SARAH	608..655	CDD:288481

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910